Potential Risk of Senescence on Male fertility and Sperm DNA damage on Progeny

2017 ◽  
Vol 1 (2) ◽  
pp. 58-62 ◽  
Author(s):  
Mathias Emokpae ◽  
◽  
Patrick Uadia ◽  
Keyword(s):  
Dna Damage ◽  
Potential Risk ◽  
Male Fertility ◽  
Sperm Dna Damage ◽  
Sperm Dna

Sperm DNA Damage and Antioxidant Use: Roles in Male Fertility

2012 ◽  
pp. 307-315
Author(s):  
Ashok Agarwal ◽  
Aspinder Singh
Keyword(s):  
Dna Damage ◽  
Male Fertility ◽  
Sperm Dna Damage ◽  
Sperm Dna

scholarly journals Single and Double Strand Sperm DNA Damage: Different Reproductive Effects on Male Fertility

Genes ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 105 ◽  
Author(s):  
Jordi Ribas-Maynou ◽  
Jordi Benet
Keyword(s):  
Dna Damage ◽  
Male Fertility ◽  
Sperm Chromatin ◽  
Dna Breaks ◽  
Sperm Dna Damage ◽  
Reproductive Effects ◽  
Double Strand Dna Breaks ◽  
Sperm Dna ◽  
Break Points ◽  
Double Strand Dna

Reproductive diseases have become a growing worldwide problem and male factor plays an important role in the reproductive diagnosis, prognosis and design of assisted reproductive treatments. Sperm cell holds the mission of carrying the paternal genetic complement to the oocyte in order to contribute to an euploid zygote with proper DNA integrity. Sperm DNA fragmentation had been used for decades as a male fertility test, however, its usefulness have arisen multiple debates, especially around Intracytoplasmic Sperm Injection (ICSI) treatments. In the recent years, it has been described that different types of sperm DNA breaks (single and double strand DNA breaks) cause different clinical reproductive effects. On one hand, single-strand DNA breaks are present extensively as a multiple break points in all regions of the genome, are related to oxidative stress and cause a lack of clinical pregnancy or an increase of the conception time. On the other hand, double-strand DNA breaks are mainly localized and attached to the sperm nuclear matrix as a very few break points, are possibly related to a lack of DNA repair in meiosis and cause a higher risk of miscarriage, low embryo quality and higher risk of implantation failure in ICSI cycles. The present work also reviews different studies that may contribute in the understanding of sperm chromatin as well as treatments to prevent sperm DNA damage.

Sperm DNA damage and cytokines in varicocele: A case‐control study

Andrologia ◽  
2021 ◽  
Author(s):  
Renata Finelli ◽  
Francesco Pallotti ◽  
Francesco Cargnelutti ◽  
Fabiana Faja ◽  
Tania Carlini ◽  
...  
Keyword(s):  
Dna Damage ◽  
Case Control Study ◽  
Case Control ◽  
Sperm Dna Damage ◽  
Sperm Dna ◽  
Control Study
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