Frequent ejaculation. a pilot study of changes in sperm DNA damage and semen parameters using daily ejaculation

2007 ◽  
Vol 88 ◽  
pp. S19-S20 ◽  
Author(s):  
D.J. Greening
Keyword(s):  
Dna Damage ◽  
Pilot Study ◽  
Semen Parameters ◽  
Sperm Dna Damage ◽  
Sperm Dna

scholarly journals The aging male: Relationship between male age, sperm quality and sperm DNA damage in an unselected population of 3124 men attending the fertility centre for the first time

2019 ◽  
Vol 90 (4) ◽  
pp. 254-259 ◽  
Author(s):  
Alessandro Colasante ◽  
Maria Giulia Minasi ◽  
Filomena Scarselli ◽  
Valentina Casciani ◽  
Vincenzo Zazzaro ◽  
...  
Keyword(s):  
Dna Damage ◽  
Sperm Morphology ◽  
Semen Quality ◽  
Sperm Quality ◽  
World Health ◽  
Semen Parameters ◽  
Sperm Dna Fragmentation ◽  
Sperm Dna Damage ◽  
Male Age ◽  
Sperm Dna

Objective: the aim of our study was to put forward insights to treat any possible correlation among sperm quality, sperm DNA damage and male age as they may have fertility implications for men who choose to delay fatherhood. Materials and methods: Our study is a non-interventional retrospective analysis of 3124 semen samples from patients that were investigated for the conventional semen parameters. Tunel test assay was set up for the evaluation of the sperm DNA fragmentation index (DFI). We applied the Kappa index to compare both the 1999 and the 2010 World Health Organization (WHO) reference criteria to evaluate the competence of such semen parameters categorization during the standard routine of our laboratory. Results: With regards to our findings, it is possible to underline a significant relationship between aging and semen volume (p = 0.001), motility (p = 0.009), semen viscosity (p < 0.003) and sperm DNA damage (p < 0.009). We found a trend when focusing on the semen concentration (p = 0.05). The analysis of sperm morphology did not show any influence with advancing age (p = 0.606). When comparing both the 1999 and the 2010 WHO scales we found no accordance in the appraisal of sperm morphology but a very good one in the evaluation of the other parameters. Conclusions: Conventional semen analysis represents the opportunity to draw up a proxy insight on the male fertility status even if semen quality can only indirectly assess the probability of pregnancy. Several studies have verified a decay in the male reproductive system, sperm quality and fertility with advancing age although the reported results are not yet conclusive. Our results substantially agree with those findings outlined in the literature. Moreover we find that the discrepancy between the two WHO reference scales would eventually lead to an improper diagnosis of infertility.

scholarly journals Mitigating the Effects of Oxidative Sperm DNA Damage

Antioxidants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 589
Author(s):  
Taylor Pini ◽  
Rachel Makloski ◽  
Karen Maruniak ◽  
William B. Schoolcraft ◽  
Mandy G. Katz-Jaffe
Keyword(s):  
Dna Damage ◽  
Dna Fragmentation ◽  
Post Treatment ◽  
Semen Parameters ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Sperm Dna Fragmentation ◽  
Success Rates ◽  
Sperm Dna Damage ◽  
Sperm Dna ◽  
Cost Effective Treatment

Sperm DNA damage is correlated with reduced embryo development and increased miscarriage risk, reducing successful conception. Given its links with oxidative stress, antioxidants have been investigated as a potential treatment, yet results are conflicting. Importantly, individual antioxidants are not identical in composition, and some compounds may be more effective than others. We investigated the use of the polyphenol-rich, high-antioxidant-capacity fruit acai as a treatment for elevated sperm DNA fragmentation (>16%), measured by terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL). Following ≥ 74 days of treatment, we observed a significant decrease in sperm DNA fragmentation (−17.0% ± 2.5%) to 11.9 ± 1.7% (0–37%), with a 68.6% success rate (defined as post-treatment TUNEL < 16%). Post-treatment decreases in DNA fragmentation and success rates were not significantly impacted by low motility and/or concentration, or exceptionally high (> 25%) TUNEL. Treatment significantly reduced concentration in men with normal semen parameters, but 88% remained normal. Overall, successful treatment was not associated with age, semen parameters or TUNEL result at baseline. However, body mass index was significantly higher in nonresponders at baseline. This study provides evidence of a low-cost, effective treatment for elevated sperm DNA damage using acai.

scholarly journals Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

2017 ◽  
Vol 9 (13) ◽  
pp. 136
Author(s):  
Farah Hanan Fathihah Jaafar ◽  
Khairul Osman ◽  
Jaya Kumar ◽  
Siti Fatimah Ibrahim
Keyword(s):  
Dna Damage ◽  
Alcohol Consumption ◽  
Alcohol Withdrawal ◽  
Semen Parameters ◽  
Sperm Chromatin ◽  
Dna Integrity ◽  
Sperm Dna Damage ◽  
Sperm Dna Integrity ◽  
Sperm Dna ◽  
Keywords Alcohol

There is no solid conclusion on the conventional sperm parameters in association with alcohol consumption, evaluation of sperm DNA integrity thus become a more reliable parameter. Hereby, this literature search was performed to summarize alcohol consumption on the sperm DNA integrity. A computerized database search was done through MEDLINE via Ovid (since 1946 until August 2017) and Cochrane was used. The following set of keywords: ‘alcohol consumption OR alcohol intake OR alcohol diet OR drinking alcohol OR ethanol diet’ AND ‘sperm DNA OR sperm chromatin OR sperm genome OR sperm histone OR sperm protamine’ were utilised. 24 articles were retrieved where only five studies conform to the inclusion criteria All studies demonstrated a negative effect of alcohol consumption on sperm DNA integrity, regardless of various range of alcohol doses and duration of alcohol consumption. Out of five studies reviewed, four studies were using a different approach to measure the sperm DNA damage. Hereby, this review identified a need to use a single approach of DNA damage test by having various method of alcohol administration and/or vice versa so that the extension of sperm DNA damage to alcohol consumption will have a better conclusion. On the same note, a few studies have reported the reversibility on conventional semen parameters, none has been done on the sperm DNA damage upon alcohol withdrawal. Therefore, the role of alcohol withdrawal on the reversibility of sperm DNA damage needs to be as well investigated further.

scholarly journals Cherry laurel fruit extract counters dimethoate-induced reproductive impairment and testicular apoptosis

2020 ◽  
Vol 71 (4) ◽  
pp. 329-338
Author(s):  
Elçin Bakır ◽  
Serpil Sarıözkan ◽  
Burcu Ünlü Endirlik ◽  
Ayşe Baldemir Kılıç ◽  
Arzu Hanım Yay ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Dna Damage ◽  
Saline Group ◽  
Reproductive Organ ◽  
Semen Parameters ◽  
Organ Weights ◽  
Sperm Dna Damage ◽  
Sperm Dna ◽  
Cherry Laurel

AbstractDimethoate is an organophosphorus pesticide used against agricultural insects, which causes oxidative stress and damage in many organs, including the reproductive ones. Cherry laurel (Laurocerasus officinalis Roem.) fruit is rich in vitamins and phenolic compounds with antioxidant effect. The aim of this study was to investigate how effective its extract would be against dimethoate-induced testis and sperm damage in rats. Sixty animals were divided in six groups of 10. Group 1 (control) received only 1 mL of saline (0.9 % NaCl). Group 2 received 7 mg/kg of dimethoate in 1 mL of saline. Group 3 received 4 mg/kg of extract in 1 mL of saline. Group 4 received the extract 30 min before dimethoate administration. Group 5 received vitamin C (positive control, 100 mg/kg in 1 mL of saline) 30 min before dimethoate administration. Group 6 received only dimethoate for the first four weeks and then a combination of dimethoate and extract for another four weeks. All doses were administered daily by oral gavage. After eight weeks of treatment, the rats were euthanised and their reproductive organs removed. We took their body and reproductive organ weights and evaluated testicular oxidative stress, semen characteristics, sperm DNA damage, testicular apoptosis, and histopathological changes. Dimethoate significantly decreased body and reproductive organ weights, sperm motility and concentration, testicular superoxide dismutase, and glutathione-peroxidase activities and significantly increased lipid peroxidation, abnormal sperm rate, sperm DNA damage, testicular apoptosis, and caused histopathological lesions. Cherry laurel extract significantly countered many dimethoate-induced adverse effects, both as pre- and post-treatment, including reproductive organ weight, semen parameters, oxidant-antioxidant balance, sperm DNA integrity, testicular apoptosis, and histological structure. Our findings clearly suggest that the beneficial effects of the extract are associated with countering oxidative stress, lipid peroxidation in particular.

The effect of daily ejaculation on semen parameters and sperm DNA damage in normal men

2011 ◽  
Vol 96 (3) ◽  
pp. S233
Author(s):  
M.E. McAsey ◽  
J.A. Kontio ◽  
A. Benson ◽  
V. Gindlesperger ◽  
T. Carter ◽  
...  
Keyword(s):  
Dna Damage ◽  
Semen Parameters ◽  
Sperm Dna Damage ◽  
Sperm Dna ◽  
Normal Men

scholarly journals Standard Semen Parameters vs. Sperm Kinematics to Predict Sperm DNA Damage

2021 ◽  
Vol 39 (1) ◽  
pp. 116 ◽  
Author(s):  
Artin Aghazarian ◽  
Wolfgang Huf ◽  
Heinz Pflüger ◽  
Tobias Klatte
Keyword(s):  
Dna Damage ◽  
Semen Parameters ◽  
Sperm Dna Damage ◽  
Sperm Dna

A cost effective method of sperm DNA damage assessment that correlates with semen parameters

2007 ◽  
Vol 88 ◽  
pp. S379
Author(s):  
J.P. Alukal ◽  
B.B. Najari ◽  
L. Murthy ◽  
O. Mohamed ◽  
L.I. Lipshultz ◽  
...  
Keyword(s):  
Dna Damage ◽  
Damage Assessment ◽  
Cost Effective ◽  
Semen Parameters ◽  
Sperm Dna Damage ◽  
Cost Effective Method ◽  
Sperm Dna

scholarly journals Varicocele-Associated Infertility and the Role of Oxidative Stress on Sperm DNA Fragmentation

2021 ◽  
Vol 3 ◽  
Author(s):  
Guilherme Jacom Abdulmassih Wood ◽  
João Paulo Greco Cardoso ◽  
Davi Vischi Paluello ◽  
Thiago Fagundes Nunes ◽  
Marcello Cocuzza
Keyword(s):  
Dna Damage ◽  
Dna Fragmentation ◽  
The Body ◽  
Semen Parameters ◽  
Sperm Dna Fragmentation ◽  
Oxygen Species ◽  
Sperm Dna Damage ◽  
Sperm Dna ◽  
Significant Attention

Varicocele has been extensively described and studied as the most important reversible cause of male infertility. Its impact on semen parameters, pregnancy rates, and assisted reproductive outcomes have been associated with multifactorial aspects, most of them converging to increase of reactive oxygen species (ROS). More recently, sperm DNA fragmentation has gained significant attention and potential clinical use, although the body of evidence still needs further evolution. The associations between sperm DNA damage and a variety of disorders, including varicocele itself, share common pathways to ROS increase. This mini-review discusses different aspects related to the etiology of ROS and its relation to varicocele and potential mechanisms of DNA damage.

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