Isolation and Characterization of Bacteria with Multiple Drug Resistance from Pig Dung

2021 ◽  
Vol 5 (8) ◽  
pp. 1506-1514
Keyword(s):  
Drug Resistance ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Isolation And Characterization

scholarly journals Ubiquitous Conjugative Mega-Plasmids of Acinetobacter Species and Their Role in Horizontal Transfer of Multi-Drug Resistance

2021 ◽  
Vol 12 ◽  
Author(s):  
Sofia Mindlin ◽  
Olga Maslova ◽  
Alexey Beletsky ◽  
Varvara Nurmukanova ◽  
Zhiyong Zong ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Multiple Drug Resistance ◽  
Antibiotic Resistance Genes ◽  
Multi Drug Resistance ◽  
Clear Correlation ◽  
Multiple Drug ◽  
Special Role ◽  
Acinetobacter Species ◽  
Group Iii

Conjugative mega-plasmids play a special role in adaptation since they carry a huge number of accessory genes, often allowing the host to develop in new niches. In addition, due to conjugation they are able to effectively spread themselves and participate in the transfer of small mobilizable plasmids. In this work, we present a detailed characterization of a recently discovered family of multiple-drug resistance mega-plasmids of Acinetobacter species, termed group III-4a. We describe the structure of the plasmid backbone region, identify the rep gene and the origin of plasmid replication, and show that plasmids from this group are able not only to move between different Acinetobacter species but also to efficiently mobilize small plasmids containing different mob genes. Furthermore, we show that the population of natural Acinetobacter strains contains a significant number of mega-plasmids and reveal a clear correlation between the living conditions of Acinetobacter strains and the structure of their mega-plasmids. In particular, comparison of the plasmids from environmental and clinical strains shows that the genes for resistance to heavy metals were eliminated in the latter, with the simultaneous accumulation of antibiotic resistance genes by incorporation of transposons and integrons carrying these genes. The results demonstrate that this group of mega-plasmids plays a key role in the dissemination of multi-drug resistance among Acinetobacter species.

scholarly journals Characterization of the Vibrio cholerae vceCAB Multiple-Drug Resistance Efflux Operon in Escherichia coli

2005 ◽  
Vol 187 (15) ◽  
pp. 5500-5503 ◽  
Author(s):  
Robin C. Woolley ◽  
Govindsamy Vediyappan ◽  
Matthew Anderson ◽  
Melinda Lackey ◽  
Bhagavathi Ramasubramanian ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Drug Resistance ◽  
Vibrio Cholerae ◽  
Efflux Pump ◽  
Multiple Drug Resistance ◽  
Multiple Drug

ABSTRACT Herein, we identify vceC as a component of a vceCAB operon, which codes for the Vibrio cholerae VceAB multiple-drug resistance (MDR) efflux pump, and vceR, which codes for a transcriptional autoregulatory protein that negatively regulates the expression of the vceCAB operon and is modulated by some of the substrates of this MDR efflux pump.

scholarly journals Survey of socio-demographic prevalence, risk factors and clinical characterization of tuberculosis in Nishtar Hospital Multan.

2016 ◽  
Vol 2 (1) ◽  
pp. 8 ◽  
Author(s):  
Sana Sharif ◽  
Nazar Mohammad Ranjha ◽  
Abdul Majeed ◽  
Ghulam Abbas ◽  
Muhammad Tuqeer Ajmal ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Risk Factors ◽  
Drug Resistance ◽  
Family History ◽  
Alcohol Consumption ◽  
Young People ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
History Of

Tuberculosis is a worldwide health problem affecting one third of world’s population and Pakistan is no exception. In this study, we used a structured and close-ended questionnaire to collect data about socio-demographic prevalence of tuberculosis, its risk factors, multiple drug resistance tuberculosis and clinical characterization of tuberculosis from Nishtar Hospital Multan, Pakistan. Tuberculosis is an infectious disease, affecting young people and females more commonly in Pakistan. Urbanization, illiteracy, poverty, family history of TB, associated immunosuppressive disorders, smoking and alcohol consumption are major drivers of tuberculosis. Multiple drug resistance tuberculosis is also an emerging problem.

scholarly journals Diversity of plasmids responsible for multiple resistance in klebsiella serotype K2

1981 ◽  
Vol 86 (2) ◽  
pp. 189-194 ◽  
Author(s):  
Hilary Richards ◽  
Victoria Hughes ◽  
Naomi Datta
Keyword(s):  
Drug Resistance ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Multiple Resistance ◽  
Capsular Type ◽  
Epidemic Clone ◽  
Resistance Plasmids ◽  
Bacterial Clone ◽  
Serotype K2

SUMMARYKlebsiella of capsular type K2 were investigated to find out whether a single epidemic clone was the source of many outbreaks of infection in different hospitals, in different areas over a period of five years. The klebsiellas studied were found to be very similar; they were of the same biotype, had similar klebecin sensitivity patterns and carried multiple drug-resistance plasmids; however, characterization of these plasmids showed that they were heterogeneous. Thus there was not a single epidemic bacterial clone.

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