scholarly journals Methods and means of asymutal-invariant muller matrix polyarimetry of optical and anisotropic biological layers

2019 ◽  
Keyword(s):  
Differential Diagnostics ◽  
Experimental Development ◽  
Coronary Insufficiency ◽  
Theoretical Substantiation ◽  
Histological Sections ◽  
The Matrix ◽  
Acute Coronary Insufficiency ◽  
Matrix Mapping ◽  
Matrix Invariant ◽  
Based Medicine

Objectives: The work is aimed at the theoretical substantiation and experimental development of the azimuthally invariant polarimetry method of partially depolarizing optical anisotropic biological layers on the basis of coordinate Muller-matrix mapping of histological sections for differential diagnostics of changes in optical anisotropy, which are associated with the emergence of pathological states. Results: The method of azimuthally invariant Muller-matrix mapping of optically anisotropic samples of the myocardium is proposed and grounded. The values of azimuthally invariant matrix element, superposition of matrix elements and the magnitude of the matrix vector distributions are obtained. Conclusion: The magnitude of the 1st-4th order statistical moments’ dependences, which characterize the distribution of the Muller-matrix invariant (MMI) of the histological sections of the myocardium are determined. The study of the possibility of differentiating causes of death due to ischemic heart disease (IHD) and acute coronary insufficiency (ACI) conducted from the standpoint of evidence-based medicine.

scholarly journals Differential Mueller matrix imaging of partially depolarizing optically anisotropic biological tissues

2019 ◽  
Vol 35 (4) ◽  
pp. 877-891 ◽  
Author(s):  
L. Trifonyuk ◽  
A. Sdobnov ◽  
W. Baranowski ◽  
V. Ushenko ◽  
O. Olar ◽  
...  
Keyword(s):  
Biological Tissues ◽  
Mueller Matrix ◽  
Differential Diagnostics ◽  
Matrix Elements ◽  
Polycrystalline Structure ◽  
First Order ◽  
Histological Sections ◽  
Laser Polarimetry ◽  
Matrix Mapping ◽  
Differential Matrix

AbstractSince recently, a number of innovative polarization-based optical imaging modalities have been introduced and extensively used in various biomedical applications, with an ultimate aim to attain the practical tool for the optical biopsy and functional characterization of biological tissues. The techniques utilize polarization properties of light and Mueller matrix mapping of microscopic images of histological sections of biological tissues or polycrystalline films of biological fluids. The main drawback of currently developed laser polarimetry approaches and Mueller matrix mapping techniques is poor reproducibility of experimental data. This is due to azimuthal dependence of polarization and ellipticity values of most matrix elements to sample orientation in respect to incidence light polarization. Current study aims to generalize the methods of laser polarimetry for diagnosis of partially depolarizing optically anisotropic biological tissues. A method of differential Mueller matrix mapping for reconstruction of linear and circular birefringence and dichroism parameter distributions of partially depolarizing layers of biological tissues of different morphological structure is introduced and practically implemented. The coordinate distributions of the value of the first-order differential matrix elements of histological sections of brain tissue with spatially structured, optically anisotropic fibrillar network, as well as of parenchymatous tissue of the rectum wall with an “islet” polycrystalline structure are determined. Within the statistical analysis of polarization reproduced distributions of the averaged parameters of phase and amplitude anisotropy, the significant sensitivity of the statistical moments of the third and fourth orders to changes in the polycrystalline structure of partially depolarizing layers of biological tissue is observed. The differentiation of female reproductive sphere connective tissue is realized with excellent accuracy. The differential Mueller matrix mapping method for reconstruction of distributions of linear and circular birefringence and dichroism parameters of partially depolarizing layers of biological tissues of different morphological structures is proposed and substantiated. Differential diagnostics of changes in the phase (good balanced accuracy) and amplitude (excellent balanced accuracy) of the anisotropy of the partially depolarizing layers of the vagina wall tissue with prolapse of the genitals is realized. The maximum diagnostic efficiency of the first-order differential matrix method was demonstrated in comparison with the traditional methods of polarization and Mueller matrix mapping of histological sections of light-scattering biological tissues.

scholarly journals The principles of evidential medicine for a local large-scale-selective correlation analysis of the distributions of ellipticity for the polarization of laser digital microscopic images of the myocardium under the conditions of acute ischemia

2013 ◽  
Vol 17 (3 (67) p.1) ◽  
pp. 20-24
Author(s):  
O. Ya. Wanchuliak
Keyword(s):  
Correlation Analysis ◽  
Large Scale ◽  
Human Myocardium ◽  
Acute Ischemia ◽  
Evidence Based ◽  
Coronary Insufficiency ◽  
Operational Characteristics ◽  
Show Evidence ◽  
Acute Coronary Insufficiency ◽  
Based Medicine

This paper ascertains the use of indicators that objectively show evidence of damage to the human myocardium under conditions of acute ischemia. On the basis of the principles of evidence-based medicine, the feasibility, effectiveness, and operational characteristics of the application of wavelet analysis of the correlation structure of maps of ellipticity in polarization laser images for the diagnosis of acute coronary insufficiency are shown.

scholarly journals Informational content and operational characteristics of a correlation analysis of laser microscopic images of the refringence structures of the myocardium for the diagnostics of acute coronary insufficiency

2013 ◽  
Vol 17 (3 (67) p.1) ◽  
pp. 25-27
Author(s):  
O. Ya. Wanchulyak ◽  
M. M. Vatsyk ◽  
N. V. Tymoshchuk ◽  
Ya. S. Kyshkan ◽  
N. O. Maksymchuk
Keyword(s):  
Correlation Analysis ◽  
Evidence Based Medicine ◽  
Informational Content ◽  
Evidence Based ◽  
Coronary Insufficiency ◽  
Microscopic Images ◽  
Operational Characteristics ◽  
Acute Coronary Insufficiency ◽  
Based Medicine

This paper, from the standpoint of evidence-based medicine, justifies the prospects of using correlation analysis of polarization-inhomogeneous laser images of ray-refractive structures of the myocardium for the diagnosis of acute coronary insufficiency.

scholarly journals Current Approaches in Management of Patients with Hypophosphatasia

2021 ◽  
Vol 17 (6) ◽  
pp. 519-528
Author(s):  
Alexander A. Baranov ◽  
Leyla S. Namazova-Baranova ◽  
Sergey I. Kutsev ◽  
Tea V. Margieva ◽  
Nato D. Vashakmadze ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Genetic Disease ◽  
Pediatric Patients ◽  
Clinical Guideline ◽  
Treatment Guidelines ◽  
Differential Diagnostics ◽  
Evidence Based ◽  
Specific Alkaline Phosphatase ◽  
Enzyme Replacement ◽  
Based Medicine

he authors present the latest data on the hypophosphatasia (HPP) management in children. Hypophosphatasia is a rare genetic disease caused by deficiency of tissue-specific alkaline phosphatase due to mutation in the ALPL gene. The article covers all the features of epidemiology, etiology and pathogenesis, detailed stages of differential diagnostics. Treatment guidelines for pediatric patients are provided, they are based on the principles of evidence-based medicine. Special attention was given to the only effective method of hypophosphatasia management —enzyme replacement therapy (ERT). This material is the clinical guideline draft for the management of patients with hypophosphatasia prepared by the Union of Pediatricians of Russia and the Association of Medical Geneticists.

scholarly journals Polarization-Singular Approach to Imaging Mueller-Matrix Polarimetry in the Differential Diagnosis of Histological Sections of Biopsy of Tumors of the Uterus and Prostate

2021 ◽  
Vol 9 ◽  
Author(s):  
A. Dubolazov ◽  
V. Ushenko ◽  
L. Trifonyuk ◽  
A. Stashkevich ◽  
I. Soltys ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mueller Matrix ◽  
Evidence Based ◽  
Malignant Tumours ◽  
Diagnostic Use ◽  
Matrix Mapping ◽  
Adenocarcinoma Of The Prostate ◽  
Characteristic Values ◽  
Sensitivity Specificity ◽  
Based Medicine

The possibilities of the diagnostic use of the singular approach of the distributions of the number of characteristic values of the MMI is effective for differentiating the polarization properties of histological biopsy sections of benign and malignant tumours of the uterus and prostate. Within the framework of evidence-based medicine, the sensitivity, specificity and accuracy of the azimuthal-invariant express (∼15 min) method of Mueller-matrix mapping of polarization-singular states in the differential diagnosis of uterine myoma and adenocarcinoma, as well as adenocarcinoma of the prostate with varying degrees of differentiation have been determined.

Pulmonary Embolism: A Precipitating Factor of Acute Coronary Insufficiency

1949 ◽  
Vol 15 (1) ◽  
pp. 72-82 ◽  
Author(s):  
SIMON DACK ◽  
JACOB STONE ◽  
DAVID H. PALEY ◽  
ARTHUR M. MASTER
Keyword(s):  
Pulmonary Embolism ◽  
Coronary Insufficiency ◽  
Acute Coronary Insufficiency ◽  
Precipitating Factor

scholarly journals Spatial-Frequency Azimuthally Stable Cartography of Biological Polycrystalline Networks

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
V. A. Ushenko ◽  
N. D. Pavlyukovich ◽  
L. Trifonyuk
Keyword(s):  
Spatial Frequency ◽  
Optical Activity ◽  
Polarization Plane ◽  
Biological Tissues ◽  
Uterine Wall ◽  
Beam Polarization ◽  
Linear Birefringence ◽  
Histological Sections ◽  
The Matrix ◽  
Anisotropic Structures

A new azimuthally stable polarimetric technique processing microscopic images of optically anisotropic structures of biological tissues histological sections is proposed. It has been used as a generalized model of phase anisotropy definition of biological tissues by using superposition of Mueller matrices of linear birefringence and optical activity. The matrix elementM44has been chosen as the main information parameter, whose value is independent of the rotation angle of both sample and probing beam polarization plane. For the first time, the technique of concerted spatial-frequency filtration has been used in order to separate the manifestation of linear birefringence and optical activity. Thereupon, the method of azimuthally stable spatial-frequency cartography of biological tissues histological sections has been elaborated. As the analyzing tool, complex statistic, correlation, and fractal analysis of coordinate distributions ofM44element has been performed. The possibility of using the biopsy of the uterine wall tissue in order to differentiate benign (fibromyoma) and malignant (adenocarcinoma) conditions has been estimated.

Sign in / Sign up

Export Citation Format

Share Document