Study of clinical profile and short-term outcome of neonates requiring assisted mechanical ventilation

Objective: To determine the clinical profile, selected antepartum and intrapartum risk factor for adverse shortterm outcomes of hypoxic ischemic encephalopathy in babies with birth asphyxia. Study Design: Cross sectional study. Place and Duration of Study: Neonatal Intensive Care Unit of Pak Emirates Military Hospital, Rawalpindi, fromJan to Dec 2018. Methodology: This study including all birth asphyxiated babies born who fulfilled the inclusion criteria.Following data was collected prospectively regarding gender, gestational age, birth weight and mode of delivery, maternal age, antenatal follow up, history of premature rupture of membranes and meconium stained liquor. Babies were categorized into different stages of hypoxic ischemic encephalopathy according to Sarnat and Sarnat staging. Selected antepartum and intrapartum risk factors leading to hypoxic insult at birth were studied and short-term outcome was recorded in the form of need of mechanical ventilation, mortality and discharge from the hospital.Results: The frequency of birth asphyxia turned out to be 122/5986 (2.03%) at our center. Thirty four (27.87%)required mechanical ventilation, mortality was recorded at 20/122 (16.39%). While 61 (50%) babies suffered from stage I hypoxic ischemic encephalopathy, 13/20 (65%) of newborn who expired were suffering from grade III hypoxic ischemic encephalopathy. Conclusion: The severity of hypoxic ischemic encephalopathy affects the outcome of newborns having birthasphyxia with hypoxic ischemic encephalopathy grade III associated with maximum mortality. Early identifycation of pregnancies at risk for asphyxia, with appropriate intervention in selected cases is the key to prevent birth asphyxia and its ensuing neonatal complications.

Download Full-text

Clinical Profile and Short Term Outcome of Children with Neutropenia

The Indian Journal of Pediatrics ◽

10.1007/s12098-019-03020-4 ◽

2019 ◽

Vol 86 (11) ◽

pp. 1017-1020 ◽

Cited By ~ 1

Author(s):

Akanksha Mahajan ◽

Virendra Kumar ◽

Sangeeta Pahuja Sindhwani ◽

Viswas Chhapola

Keyword(s):

Clinical Profile ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

Download Full-text

Clinical Profile and Short-Term Outcome of Children With SARS-CoV-2 Related Multisystem Inflammatory Syndrome (MIS-C) Treated With Pulse Methylprednisolone

Indian Pediatrics ◽

10.1007/s13312-021-2277-4 ◽

2021 ◽

Vol 58 (8) ◽

pp. 718-722

Author(s):

Sheeja Sugunan ◽

S. Bindusha ◽

S. Geetha ◽

H. R. Niyas ◽

A. Santhosh Kumar

Keyword(s):

Clinical Profile ◽

Short Term ◽

Term Outcome ◽

Pulse Methylprednisolone ◽

Short Term Outcome ◽

Inflammatory Syndrome

Download Full-text

Clinical Profile and Short-Term Outcome of Neonatal Seizures in a Tertiary Care Hospital, Kuppam – A Retrospective Study

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/442 ◽

2021 ◽

Vol 8 (27) ◽

pp. 2381-2386

Author(s):

Poojitha Kancherla ◽

Harsha P.J. ◽

Gowtham R. ◽

Dowlath Anwar Basha ◽

Chandran G.P ◽

...

Keyword(s):

Tertiary Care ◽

Clinical Profile ◽

Hypoxic Ischemic Encephalopathy ◽

Care Hospital ◽

Neonatal Seizures ◽

Metabolic Disturbances ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome ◽

Ischemic Encephalopathy

BACKGROUND Neonates presenting with seizures require long term stay in hospital and have higher chances of neuro-developmental delay later. Seizures in neonates are mostly subtle and difficult to diagnose. We wanted to study the clinical profile and short-term outcome on term and later pre-term neonates presenting with seizures. METHODS The study was a retrospective observational study done from November to December 2020 at PES Hospital, Kuppam. Retrospective data of neonatal seizures from May 2019 to April 2020 was considered for study. Details from the case records of neonates with seizures was collected. RESULTS Neonatal seizures (NS) were most common in females (53.8 %, 72/134). Subtle seizures were most common form of seizures in neonates which was seen in 64.2 % (86/134) babies followed by tonic seizures in 22.4 % (30/134). Neonatal seizures were most commonly seen in babies with hypoxic ischemic encephalopathy in 63.4 % (85/134) followed by metabolic disturbances in 15.6 % (21/134) and meningitis in 13.5 % (18/134). In babies with hypoxic ischemic encephalopathy, metabolic and meningitis subtle seizures were observed to be more common. Seizures were seen most commonly in first 72 hours of life (82.85 %, 111/134). Seizures in babies with hypoxic ischemic encephalopathy, metabolic causes most commonly occurred within first 24 hours of birth. Seizures in babies with meningitis most commonly occurred after 7 days of birth. Babies with neonatal seizures with sequelae was seen in 17.96 % (24/134) and 11.94 % babies died (16/134). CONCLUSIONS Subtle seizures were most common form and hypoxic ischemic encephalopathy was most common risk factor. Most neonatal seizures present within 72 hours of birth. Babies with meningitis presented with seizures most commonly after 72 hours of birth. KEYWORDS Hypoxic Ischemic Encephalopathy, Neonatal Seizures, Newborn, Aetiology, Outcome

Download Full-text

Clinical Profile and Short Term Outcome of Adult Patients with Acute Myeloid Leukemia

Indian Journal of Hematology and Blood Transfusion ◽

10.1007/s12288-018-1051-9 ◽

2018 ◽

Vol 35 (3) ◽

pp. 431-436 ◽

Cited By ~ 2

Author(s):

Sherin Jacob ◽

Sajini Elizabeth Jacob ◽

Bettadpura Shamanna Suryanarayana ◽

Tarun Kumar Dutta

Keyword(s):

Acute Myeloid Leukemia ◽

Myeloid Leukemia ◽

Adult Patients ◽

Clinical Profile ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome ◽

Acute Myeloid

Download Full-text

Factors Affecting Short-Term Outcome of Critically Ill Children with Malignancies Admitted in Pediatric Intensive Care Unit: A Retrospective Observational Study

Indian Journal of Medical and Paediatric Oncology ◽

10.1055/s-0041-1733824 ◽

2021 ◽

Vol 42 (04) ◽

pp. 333-338

Author(s):

Priyanka Aggarwal ◽

Ishan Kumar ◽

Sunil Kumar Rao ◽

K Pradhap ◽

Vineeta Gupta

Keyword(s):

Risk Factors ◽

Intensive Care Unit ◽

Mechanical Ventilation ◽

Adverse Outcome ◽

Pediatric Intensive Care ◽

Critically Ill Children ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome ◽

The Mean

Abstract Introduction Pediatric cancer contributes <1% of all malignancies. Childhood cancer survival has improved dramatically with the use of more intensive chemotherapy regimens, better stratification, and improvement in supportive care with enhanced facilities in pediatric intensive care unit (PICU). Objective The aim of this study was to identify the risk factors responsible for poor outcome in critically ill children with malignancies admitted in PICU. Materials and Methods Sixty-four children with a primary diagnosis of malignancy admitted in PICU with disease or treatment related complications were enrolled retrospectively. The short-term outcome, that is, shifting from PICU to ward, was assessed in relation to the presence of febrile neutropenia, organ failure, hepatitis, acute renal failure as well as requirement of inotropes and mechanical ventilation. Death was considered as an adverse outcome in this study. Results The mean age of study population was 6.25 ± 3.91 and M:F ratio 2.4:1. The majority of children had hematological malignancies (81.25%), that is, pre-B acute lymphoblastic leukemia (ALL) (45.3%), non-Hodgkin lymphoma (21.3%), acute myeloid leukemia (12.5%), T ALL (10.9%), and Hodgkin lymphoma (3.1%). Few children also had retinoblastoma (4.7%) and Langerhans cell histiocytosis (1.6%). The mean duration of PICU stay was 3.16 ± 2.31 days. Sepsis (37.5%) was the most common indication for PICU admission, followed by metabolic disturbance (26.6%), respiratory failure (17.2%), neurological complaints (15.6%), and anaphylactic shock (3.1%). Children requiring mechanical ventilation (p < 0.001), inotrope support (p < 0.001), having acute renal failure (p = 0.001), and >1 organ failure (p < 0.001) were associated with adverse outcome. The overall survival at the time of discharge from PICU was 64%. Conclusion In the context of low- and middle-income countries, optimal resource utilization by early identification of risk factors for clinical deterioration is required to allow timely admission to PICU and delivery of life-saving therapy to salvageable patients.

Download Full-text