Study of clinical profile of dengue fever at tertiary care hospital in rural Maharashtra

Background: Dengue haemorrhagic fever is a potentially lethal illness that is universally prevalent in the tropics and has become a major health concern globally in recent decades. The clinical manifestation of dengue infection varies from asymptomatic to severe life threatening illness in the form of DHF/DSS. Dengue haemorrhagic fever or DSS may be fatal in 40% to 50% of untreated patients. A hallmark of dengue infection is severe thrombocytopenia which causes concern for the patients and treating doctors. The objective of this study was to correlate clinical profile during the evolution of dengue fever with severe thrombocytopenia (platelets <10,000/mm3), and comparing frequencies between the different clinical forms in order to predict the severity of the disease. The present study includes 40 individuals who were found to be seropositive with the detection of NS1Ag, IgM and IgG antibodies for dengue infection with severe thrombocytopenia. Early diagnosis and monitoring is largely dependent on haematological parameters. As no specific antiviral therapy is available, supportive therapy is of utmost importance.Methods: This is an observational, descriptive and retrospective study of 40 patients with clinical and serological diagnosis of dengue fever with severe thrombocytopenia (platelets<10,000/mm3), in the period from August 2015 to September 2016, who were admitted in a tertiary care hospital in South India. ELISA was performed for the detection of dengue NS1, Ig M and Ig G, haematological parameters by automated analyzer and peripheral smear, coagulation profile analysis were done.Results: Out of 40 cases with severe thrombocytopenia, 50% of the patients had classical dengue fever, 30% cases had DHF with bleeding manifests and 20% cases with DHF plasma leakage signs and 5% lead to DSS. There was lack of association studied between severe thrombocytopenia and bleeding manifestations as p value<0.065 was insignificant. However, the risk of complications increased with decreasing platelet counts in the present study.Conclusions: Thrombocytopenia was most predominant haematological discrepancy. There was no predilection for any age group or gender for thrombocytopenia or bleeding among the dengue patients. The results were relevant in assessing the severity of infection and can help by enabling the adaptation of the therapeutic conduct to the needs of individual patients.

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A study of clinical profile of patients with Dengue fever at a tertiary care hospital

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20180085 ◽

2018 ◽

Vol 5 (1) ◽

pp. 202 ◽

Cited By ~ 1

Author(s):

Sreenivasulu T. ◽

Jahnavi K.

Keyword(s):

Dengue Fever ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Cross Sectional Study ◽

Clinical Profile ◽

Care Hospital ◽

Age Group ◽

Sectional Study ◽

Cross Sectional ◽

Presenting Symptoms

Background: Dengue is the most common fever. Among all flavi-viruses, it is the most common. It can cause around 50-100 million infections. Every year 2-5 lakh cases of Dengue hemorrhagic fever occur. The objective of the research was to study clinical profile of patients with Dengue fever at a tertiary care hospital.Methods: Present study was cross sectional study. The patients were interviewed and examined at one point of time and later they were never followed which is similar to the cross-sectional study design. Present study was carried out in the hospital. This was done in the department of General Medicine of a tertiary care hospital. Present study was carried out over a period of one year.Results: In the present study, there were 78 males and 22 females. The sex ratio was 3.5:1. Maximum number of males (29.5%) was in the age group of 15-25. Among females, the maximum (40.9%) were in the age group of 26-35 years and 46-55 years (9%). The most common presenting symptom was fever in all cases followed by headache in 90%. Among bleeding manifestations, epistaxis, gum bleeding and hematuria (15%) were the common symptoms. Most patients presented with generalized lymphadenopathy in 52%. 56 patients showed only hepatomegaly and 46 splenomegaly, and 30 patients showed hepato splenomegaly. 99 showed leucopenia and 10 were anemic and 25 showed platelet count less than 1,50,000cells/cumm.Conclusions: Males were commonly affected. Younger age group of 15-25 was most commonly affected and fever and headache were the most common presenting symptoms. These findings help physicians in early diagnosis of dengue by suspecting these features as of dengue and can prevent morbidity and mortality associated with dengue.

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