A prospective study of clinical profile of patients with acute kidney injury following acute gastroenteritis

2020 ◽  
Vol 13 (1) ◽  
pp. 38-42
Author(s):  
Vikas Ramchandra Ratnaparkhe ◽  
◽  
Durgesh Kashinath Parhe ◽  
2020 ◽  
Vol 14 (10) ◽  
pp. 879-894
Author(s):  
Hayton Chui ◽  
Jillian Caldwell ◽  
Mariya Yordanova ◽  
Vedran Cockovski ◽  
Daniel Fredric ◽  
...  

Aim: NGAL, IL-18, KIM-1 as well as urinary TIMP2 and IGFBP7 and their mathematical product (TIMP2*IGFBP7) were evaluated for detecting pediatric aminoglycoside acute kidney injury (AG-AKI). Methods: In a prospective study, noncritically ill children received aminoglycosides (AG) ≥3 days. The area under the curve (AUC) for biomarkers to detect AKI was calculated by a) days before AKI onset; b) treatment days. Results: There were 113 AG episodes (68% febrile neutropenia). The AKI group had a higher proportion with febrile neutropenia. The AKI group had significantly lower NGAL 3 days before AKI, as patients with febrile neutropenia had a lower NGAL during AG treatment (p < 0.05). NGAL, IL-18 and TIMP2*IGFBP7 had AUC ≥0.73 at 3, 2 and 2 days before AKI onset. Conclusion: NGAL, IL-18 and TIMP2*IGFBP7 were modest early biomarkers of AG-AKI. Febrile neutropenia was associated with lower NGAL.


2020 ◽  
Vol 44 (4) ◽  
pp. 551-563
Author(s):  
Nayana Fonseca Vaz ◽  
Vanessa Nogueira Rodrigues da Cunha ◽  
Marlone Cunha-Silva ◽  
Tiago Sevá-Pereira ◽  
Jazon Romilson de Souza Almeida ◽  
...  

2019 ◽  
Vol 33 ◽  
Author(s):  
Perditer Okyere ◽  
Isaac Okyere ◽  
Thomas Akuetteh Ndanu ◽  
Charlotte Osafo ◽  
Bright Amankwaa

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