scholarly journals Dynamics of findings of non-specific resistance in the mouth cavity in children with lesions of the mucous membrane epithelium of the mouth cavity against acute lymphoblastic leukemia in the treatment process.

2020 ◽  
Vol 25 (1) ◽  
pp. 214-220
Author(s):  
K. A. Bunyatyan ◽  
Yu. V. Khotimska ◽  
I. V. Kovach ◽  
Ya. V. Lavrenyuk ◽  
B. L. Khotimskiy
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Mucous Membrane ◽  
Treatment Process ◽  
Specific Resistance ◽  
Lymphoblastic Leukemia ◽  
Mouth Cavity

scholarly journals TdT Negativity and ETP Phenotype in Young Patients with Acute T- Lymphoid Leukemia: A Case Report

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Cetin D ◽  
◽  
Midik MM ◽  
Karadag FK ◽  
Ozsan N ◽  
...  
Keyword(s):  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Poor Prognosis ◽  
Treatment Process ◽  
Lymphoblastic Leukemia ◽  
Young Patients ◽  
Case Series ◽  
Common Condition ◽  
Lymphoid Leukemia ◽  
Young Adult Patient

TdT is generally positive in patients with T-Acute Lymphoblastic Leukemia/ Lymphoma (T-ALL/LBL) and can often become negative after chemotherapy. TdT negativity at the time of diagnosis is not a common condition and is evaluated in favor of a poor prognosis. Due to its infrequent occurrence, there are not enough clinical studies, and there are often publications on the basis of case and case series. While its incidence increases in young people and children, the possibility of accompanying Early T Precursor (ETP) phenotype also increases. The presence of the ETP phenotype has negative repercussions on prognosis. Here, we will describe the diagnosis and treatment process of a young adult patient with TdT negative T-ALL accompanied by the ETP phenotype.

scholarly journals Changes to the gastrointestinal microbiota in pediatric acute lymphoblastic leukemia: A literature review

2021 ◽  
Author(s):  
Zuzanna Zakrzewska ◽  
Szymon Skoczen ◽  
Małgorzata Czogała ◽  
Wojciech Czogała
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Gut Microbiota ◽  
Childhood Leukemia ◽  
Treatment Process ◽  
Lymphoblastic Leukemia ◽  
Overall Survival Rate ◽  
Gastrointestinal Microbiota ◽  
The Impact ◽  
Gut Microbiota Composition

The human microbiota, which consists of trillions of microorganisms, impacts the host’s health and treatment of potential diseases. The role of the microbiota in the development and treatment of childhood leukemia is still not clear. This study reviews the current scientific understanding of the changes in gut microbiota composition during chemotherapy in acute lymphoblastic leukemia (ALL) in children and assesses its impact on the treatment process. The findings show alterations in gut microbiota are obvious at the time of diagnosis of ALL. During intensive chemotherapy, dysbiosis persists, and after treatment, the microbiota restores its diversity. However, there are significant gaps in understanding the impact of gut microbiota on the severity of treatment complications and overall survival rate.

Sign in / Sign up

Export Citation Format

Share Document