scholarly journals Histone Deacetylase, Xanthine Oxidase and Urease Inhibitory Activities of Eremurus spectabilis M. Bieb. Extracts

Experimed ◽  
2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Bertan Bayrak ◽  
Refiye Yanardağ
Keyword(s):  
Xanthine Oxidase ◽  
Histone Deacetylase ◽  
Inhibitory Activities ◽  
Urease Inhibitory

Reactivity of Barbituric, Thiobarbituric Acids and Their Related Analogues: Synthesis of Substituted and Heterocycles-based Pyrimidines

2020 ◽  
Vol 24 (14) ◽  
pp. 1610-1642 ◽  
Author(s):  
Ahmed El-Mekabaty ◽  
Hassan A. Etman ◽  
Ahmed Mosbah ◽  
Ahmed A. Fadda
Keyword(s):  
Xanthine Oxidase ◽  
Multicomponent Reactions ◽  
Biological Activities ◽  
Present Review ◽  
Urease Inhibitors ◽  
Effective Catalyst ◽  
Inhibitory Activities ◽  
Catalyst Reusability ◽  
High Yields ◽  
Nano Catalysts

Barbituric, thiobarbituric acids and their related analogs are reactive synthons for the synthesis of drugs and biologically, and pharmaceutically active pyrimidines. The present review aimed to summarize the recent advances in the synthesis of different alkylsubstituted, fused cycles, spiro-, and binary heterocycles incorporated pyrimidine skeleton based on barbituric derivatives. In this sequence, the eco-friendly techniques under catalytic conditions were used for the diverse types of multicomponent reactions under different conditions for the synthesis of various types of heterocycles. Nano-catalysts are efficient for the synthesis of these compounds in high yields and effective catalyst reusability. The compounds are potent antibacterial, cytotoxic, xanthine oxidase inhibitory activities, and attend as urease inhibitors. The projected mechanisms for the synthesis of pyranopyrimidines, benzochromenopyrimidines, chromeno-pyranopyrimidines, spiroxyindoles, oxospiro-tricyclic furopyrimidines, pyrimidine-based monoand bicyclic pyridines were discussed. The potent and diverse biological activities for instance, antioxidant, antibacterial, cytotoxic, and xanthine oxidase inhibitory activities, as well as urease inhibitors, are specified.

Antioxidant, xanthine oxidase and lipoxygenase inhibitory activities and phenolics ofBauhinia rufescensLam. (Caesalpiniaceae)

2012 ◽  
Vol 26 (11) ◽  
pp. 1069-1074 ◽  
Author(s):  
M. Compaoré ◽  
C.E. Lamien ◽  
A. Lamien-Meda ◽  
L. Vlase ◽  
M. Kiendrebeogo ◽  
...  
Keyword(s):  
Xanthine Oxidase ◽  
Inhibitory Activities

Anti-hyperuricemic, Uricosuric and Xanthine-oxidase Inhibitory Activities of Watermelon Powder in a Rat Gout Model

2018 ◽  
Vol 18 (8) ◽  
pp. 468-474
Author(s):  
Basim Jasim Hameed ◽  
Falah Hassan Shari ◽  
Usama Hamid Ramadhan
Keyword(s):  
Xanthine Oxidase ◽  
Inhibitory Activities

In vitro Antioxidant, Xanthine Oxidase and Acetylcholinesterase Inhibitory Activities of Balanites aegyptiaca (L.) Del. (Balanitaceae)

2010 ◽  
Vol 13 (8) ◽  
pp. 362-368 ◽  
Author(s):  
N.T.R. Meda ◽  
A. Lamien-Med ◽  
M. Kiendrebeo ◽  
C.E. Lamien ◽  
A.Y. Coulibaly ◽  
...  
Keyword(s):  
Xanthine Oxidase ◽  
Balanites Aegyptiaca ◽  
Inhibitory Activities

In vitro Antioxidant, Lipoxygenase and Xanthine Oxidase Inhibitory Activities of Fractions from Cienfuegosia digitata Cav., Sida alba L. and Sida acuta Burn f. (Malvaceae)

2010 ◽  
Vol 13 (22) ◽  
pp. 1092-1098 ◽  
Author(s):  
K. Konate ◽  
A. Souza ◽  
A.Y. Coulibaly ◽  
N.T.R. Meda ◽  
M. Kiendrebeo ◽  
...  
Keyword(s):  
Xanthine Oxidase ◽  
Sida Acuta ◽  
Inhibitory Activities

scholarly journals Design, synthesis and evaluation of belinostat analogs as histone deacetylase inhibitors

2019 ◽  
Vol 11 (21) ◽  
pp. 2765-2778
Author(s):  
Jie-Huan Zhang ◽  
Madhusoodanan Mottamal ◽  
Hai-Shan Jin ◽  
Shanchun Guo ◽  
Yan Gu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Active Compound ◽  
Histone Deacetylase Inhibitors ◽  
Hdac Inhibitors ◽  
Antitumor Therapy ◽  
Design Synthesis ◽  
Inhibitory Activities ◽  
Antiproliferative Activities

Aim: Histone deacetylase (HDAC) is an attractive target for antitumor therapy. Therefore, the development of novel HDAC inhibitors is warranted. Materials & methods: A series of HDAC inhibitors based on N-hydroxycinnamamide fragment was designed as the clinically used belinostat analog using amide as the connecting unit. All target compounds were evaluated for their in vitro HDAC inhibitory activities and some selected compounds were tested for their antiproliferative activities. Conclusion: Among them, compound 7e showed an IC50 value of 11.5 nM in inhibiting the HDAC in a pan-HDAC assay, being the most active compound of the series.

Synthesis, cytotoxic and urease inhibitory activities of some novel isatin-derived bis-Schiff bases and their copper(ii) complexes

MedChemComm ◽  
2016 ◽  
Vol 7 (5) ◽  
pp. 914-923 ◽  
Author(s):  
Humayun Pervez ◽  
Maqbool Ahmad ◽  
Sumera Zaib ◽  
Muhammad Yaqub ◽  
Muhammad Moazzam Naseer ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Active Compound ◽  
Active Site ◽  
Binding Mode ◽  
Jack Bean Urease ◽  
Jack Bean ◽  
Inhibitory Activities ◽  
Urease Inhibitory

The putative binding mode of the most active compound 3b in the active site of Jack bean urease.

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