scholarly journals Differential Expression of LEF1 Isoforms in Adult Lymphoid and Myeloid Malignancies

Experimed ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 184-188
Author(s):  
Sinem Fırtına ◽  
Özden Hatırnaz Ng ◽  
Yücel Erbilgin ◽  
İbrahim Haznedaroğlu ◽  
Müge Sayitoğlu
Keyword(s):  
Differential Expression ◽  
Myeloid Malignancies

scholarly journals Differential expression of CD54/intercellular adhesion molecule-1 in myeloid leukemias and in lymphoproliferative disorders

Blood ◽  
1990 ◽  
Vol 76 (4) ◽  
pp. 783-790 ◽  
Author(s):  
M Maio ◽  
A Pinto ◽  
A Carbone ◽  
V Zagonel ◽  
A Gloghini ◽  
...  
Keyword(s):  
Differential Expression ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Lymphoproliferative Disorders ◽  
Intercellular Adhesion Molecule ◽  
Malignant Cells ◽  
Intercellular Adhesion Molecule 1 ◽  
Myeloid Malignancies ◽  
Lymphoid Malignancies ◽  
B Lymphoid

Abstract Indirect immunofluorescence staining with monoclonal antibody (MoAb) CL203.4 of malignant cells from 269 patients with hematologic malignancies showed a heterogeneous expression of CD54/intercellular adhesion molecule-1 (ICAM-1). This marker was expressed by malignant cells of 57 out of 118 patients with myeloid malignancies and 69 out of 135 with B-lymphoid malignancies. On the other hand, CD54 was not detected on malignant cells of 16 patients with T-lymphoid malignancies. In myeloid malignancies, CD54 is preferentially expressed by “stem cell-derived” malignancies, being detectable on blast cells from almost all patients affected by chronic myelogenous leukemia in blast phase or myelodysplastic syndromes and by only 34% of patients with de novo acute myeloid leukemia (AML). The expression of CD54 did not correlate with any specific myeloid FAB subtype, although three cases of highly undifferentiated AML (FAB MO) displayed maximal levels of the antigen. The expression of CD54 in AML was significantly associated with that of CD34 and HLA-DR antigens. In B-lymphoid malignancies, CD54 expression appears to correlate with the differentiation stage of malignant cells, since B-origin acute lymphoblastic leukemias and conventional B-chronic lymphocytic leukemias (B-CLL; ie, “dim SIg” CLL) expressed lower levels of CD54 than more mature lymphoproliferative disorders (“bright SIg” CLL, prolymphocytic leukemias, and lymphoplasmacytic tumors). “High-grade” B- cell non-Hodgkin‧s lymphomas (B-NHL) express in general a higher level of CD54 than “low-grade” ones. This finding in conjunction with the expression of CD54 in all 17 patients with “bright SIg” CLL investigated (characterized by marked organomegaly and poor prognosis) suggest that the differential expression of CD54 in lymphoproliferative disorders may also relate to their degree of malignancy.

scholarly journals Differential expression of CD54/intercellular adhesion molecule-1 in myeloid leukemias and in lymphoproliferative disorders

Blood ◽  
1990 ◽  
Vol 76 (4) ◽  
pp. 783-790 ◽  
Author(s):  
M Maio ◽  
A Pinto ◽  
A Carbone ◽  
V Zagonel ◽  
A Gloghini ◽  
...  
Keyword(s):  
Differential Expression ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Lymphoproliferative Disorders ◽  
Intercellular Adhesion Molecule ◽  
Malignant Cells ◽  
Intercellular Adhesion Molecule 1 ◽  
Myeloid Malignancies ◽  
Lymphoid Malignancies ◽  
B Lymphoid

Indirect immunofluorescence staining with monoclonal antibody (MoAb) CL203.4 of malignant cells from 269 patients with hematologic malignancies showed a heterogeneous expression of CD54/intercellular adhesion molecule-1 (ICAM-1). This marker was expressed by malignant cells of 57 out of 118 patients with myeloid malignancies and 69 out of 135 with B-lymphoid malignancies. On the other hand, CD54 was not detected on malignant cells of 16 patients with T-lymphoid malignancies. In myeloid malignancies, CD54 is preferentially expressed by “stem cell-derived” malignancies, being detectable on blast cells from almost all patients affected by chronic myelogenous leukemia in blast phase or myelodysplastic syndromes and by only 34% of patients with de novo acute myeloid leukemia (AML). The expression of CD54 did not correlate with any specific myeloid FAB subtype, although three cases of highly undifferentiated AML (FAB MO) displayed maximal levels of the antigen. The expression of CD54 in AML was significantly associated with that of CD34 and HLA-DR antigens. In B-lymphoid malignancies, CD54 expression appears to correlate with the differentiation stage of malignant cells, since B-origin acute lymphoblastic leukemias and conventional B-chronic lymphocytic leukemias (B-CLL; ie, “dim SIg” CLL) expressed lower levels of CD54 than more mature lymphoproliferative disorders (“bright SIg” CLL, prolymphocytic leukemias, and lymphoplasmacytic tumors). “High-grade” B- cell non-Hodgkin‧s lymphomas (B-NHL) express in general a higher level of CD54 than “low-grade” ones. This finding in conjunction with the expression of CD54 in all 17 patients with “bright SIg” CLL investigated (characterized by marked organomegaly and poor prognosis) suggest that the differential expression of CD54 in lymphoproliferative disorders may also relate to their degree of malignancy.

scholarly journals Initial Analysis of Lipid Metabolomic Profile Reveals Differential Expression Features in Myeloid Malignancies

2015 ◽  
Vol 06 (15) ◽  
pp. 1262-1272 ◽  
Author(s):  
Adriana Ramos de Oliveira ◽  
Ismael Dale Cotrim Guerreiro Da Silva ◽  
Edson G. Lo Turco ◽  
Helio Alves Martins Júnior ◽  
Maria de Lourdes L. Ferrari Chauffaille Chauffaille
Keyword(s):  
Differential Expression ◽  
Metabolomic Profile ◽  
Myeloid Malignancies ◽  
Initial Analysis

Differential expression of ASS1 in serous and non-serous ovarian carcinomas

2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Dong-Joo Cheon ◽  
Ann E. Walts ◽  
Jessica A. Beach ◽  
Jenny Lester ◽  
John S. Bomalaski ◽  
...  
Keyword(s):  
Differential Expression ◽  
Ovarian Carcinomas

Cloning of cDNA for newt WT1 and the differential expression during spermatogenesis of the Japanese newt, Cynops pyrrhogaster

1998 ◽  
Vol 40 (5) ◽  
pp. 599-608 ◽  
Author(s):  
Yuki Nakayama ◽  
Takashi Yamamoto ◽  
Yoshiko Matsuda ◽  
Shin-Ichi Abe
Keyword(s):  
Differential Expression ◽  
Cynops Pyrrhogaster

764: Differential Expression of RAL GTPases and their Effectors in Bladder Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 256-256
Author(s):  
Steven Smith ◽  
Gary Oxford ◽  
Dan Theodorescu
Keyword(s):  
Bladder Cancer ◽  
Differential Expression ◽  
Ral Gtpases
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