L-carnitine role in heart rate and blood lactate recovery following high intensity exercise - a double blind study following single doses

Background: Heart rate (HR) reduction with ivabradine has been proved to reduce hospitalization and death from heart failure (HF). We sought to investigate whether pyridostigmine would effectively reduce HR in patients with chronic HF as compared with ivabradine. Methods: Twenty-one patients with HF who were in sinus rhythm with a resting HR over 70 bpm, despite optimal medical treatment, were included in a randomized, double-blind study comparing pyridostigmine versus ivabradine. The initial dose of ivabradine was 5 mg twice daily to reach a target HR between 50 and 60 bpm and could be titrated to a maximum of 7.5 mg twice daily. Pyridostigmine was used in a fixed dose of 30 mg 3 times daily. Results: The baseline HR for ivabradine and pyridostigmine groups was 89.1 (13.5) and 80.1 (7.2) bpm, respectively ( P = .083). After 6 months of treatment, HR was significantly reduced to 64.8 (8.3) bpm in the ivabradine group ( P = .0014) and 63.6 (5.9) bpm in the pyridostigmine group ( P = .0001). The N-terminal pro-B-type natriuretic peptide was reduced in the ivabradine group (median: 1308.4 [interquartile range: 731-1896] vs 755.8 [134.5-1014] pg/mL; P = .027) and in the pyridostigmine group (132.8 [89.9-829] vs 100.7 [38-360] pg/mL; P = .002). Inflammatory markers interleukin-1, interleukin-6, and tumor necrosis factor were reduced in both groups. Exercise capacity was improved in both groups, with increments in volume of oxygen utilization ([Formula: see text]O2; ivabradine: 13.1 vs 15.6, P = .048; pyridostigmine: 13.3 vs 16.7, P = .032). Heart rate recovery in the first minute postexercise was improved with pyridostigmine (11.8 [3.9] vs 18 [6.5]; P = .046), but not with ivabradine (13.3 [6.9] vs 14.1 [8.2]; P = .70). No differences in either group were observed in the myocardial scintigraphy with 123-iodine-metaiodobenzylguanidine. Conclusion: Both drugs significantly reduced HR, with improvements in exercise capacity and in neurohormonal and inflammatory profiles.

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Exercise blood pressure and heart rate reduction 24 and 3 hours after drug intake in hypertensive patients follwing 4 weeks of treatment with bisoprolol and metoprolol: A randomized multicentre double-blind study (BISOMET)

European Heart Journal ◽

10.1093/eurheartj/8.suppl_m.103 ◽

1987 ◽

Vol 8 (suppl M) ◽

pp. 103-113 ◽

Cited By ~ 7

Author(s):

R. Haasis ◽

H. Bethge

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Blind Study ◽

Drug Intake ◽

Double Blind Study ◽

Heart Rate Reduction ◽

Rate Reduction ◽

Double Blind ◽

Hypertensive Patients ◽

Exercise Blood Pressure

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No Improvement in Running Time to Exhaustion at 100% VO2max in Recreationally Active Male Runners With a Preexercise Single-Carbohydrate Mouth Rinse

International Journal of Sports Physiology and Performance ◽

10.1123/ijspp.2018-0624 ◽

2019 ◽

Vol 14 (9) ◽

pp. 1178-1183

Author(s):

Luana T. Rossato ◽

Camila T.M. Fernandes ◽

Públio F. Vieira ◽

Flávia M.S. de Branco ◽

Paula C. Nahas ◽

...

Keyword(s):

Heart Rate ◽

Blood Lactate ◽

Short Duration ◽

High Intensity ◽

Rest Period ◽

Time To Exhaustion ◽

Mouth Rinse ◽

Double Blind ◽

Running Time ◽

Before And After

Background: Carbohydrate (CHO) mouth rinse has been used as an ergogenic strategy due to its central effect; however, the effects of this intervention during short-duration high-intensity exercises are not fully understood. Purpose: To investigate the effect of CHO mouth rinse on time to exhaustion in a short-duration high-intensity exercise performed on a treadmill. Methods: A randomized double-blind, placebo-controlled, crossover study was conducted with 10 (24.1 [4.3] y) recreationally active male runners. The protocol consisted of a warm-up at 65% of VO2max for 5 min followed by 3 min passive rest. At the end of this rest period, the individuals performed their mouth rinse either with CHO (maltodextrin, 6%) or with placebo (industrialized noncaloric juice with the same taste). Immediately after mouth rinse, the subjects ran at velocity equivalent to 100% of individual VO2max until voluntary exhaustion. The perceived effort was obtained through a Borg scale. Blood lactate was quantified before and after the protocol, and heart rate was evaluated during the protocol. Results: No difference was found (P = .90) in time to exhaustion between placebo (193.9 [46.5] s) and CHO mouth rinse (195.1 [51.8] s). Blood lactate, heart rate, and perception of effort increased in both groups, but with no differences (all variables, P > .05) between groups. Conclusion: The findings showed that a preexercise single-CHO mouth rinse was ineffective to improve running time to exhaustion at velocity equivalent to 100% VO2max on a treadmill in recreationally active male runners.

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S149. Randomized Double-Blind Study of Long Pulse Width vs. High Intensity Subcallosal Cingulate Stimulation for Treatment-Resistant Depression

Biological Psychiatry ◽

10.1016/j.biopsych.2018.02.1041 ◽

2018 ◽

Vol 83 (9) ◽

pp. S406

Author(s):

Rajamannar Ramasubbu ◽

Golding Sandra ◽

Mackie Aron ◽

Zelma Kiss

Keyword(s):

High Intensity ◽

Pulse Width ◽

Blind Study ◽

Double Blind Study ◽

Treatment Resistant Depression ◽

Treatment Resistant ◽

Double Blind ◽

Resistant Depression ◽

Long Pulse

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modifications of ultradian and orcadian rhythms of fetal heart rate after fetal-maternal adrenal gland suppression: A double blind study

Prenatal Diagnosis ◽

10.1002/pd.1970060604 ◽

1986 ◽

Vol 6 (6) ◽

pp. 409-417 ◽

Cited By ~ 46

Author(s):

D. Arduini ◽

G. Rizzo ◽

E. Parlati ◽

C. Giorlandino ◽

H. Valensise ◽

...

Keyword(s):

Heart Rate ◽

Adrenal Gland ◽

Fetal Heart Rate ◽

Fetal Heart ◽

Blind Study ◽

Double Blind Study ◽

Double Blind

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Efficacy of dexmedetomidine in attenuating hemodynamic and airway responses during extubation: a randomized double-blind study

Journal of Society of Anesthesiologists of Nepal ◽

10.3126/jsan.v6i1.25065 ◽

2020 ◽

pp. e223

Author(s):

Kripa Pradhan ◽

Pradip Raj Vaidya

Keyword(s):

Heart Rate ◽

Mean Arterial Pressure ◽

Arterial Pressure ◽

Drug Administration ◽

Normal Saline ◽

Blind Study ◽

Double Blind Study ◽

Double Blind ◽

Airway Responses ◽

Group D

Background Tracheal extubation causes significant hemodynamic changes and airway irritation. During smooth extubation there is absence of straining, movement, coughing, breath holding, laryngospasm and minimal change in hemodynamic. Purpose of this study was to evaluate the efficacy of dexmedetomidine in attenuating hemodynamic and airway responses during extubation. Methodology Eighty patients receiving general anesthesia were included in this randomized double-blind study. Ten minutes before the end of anesthesia, Group D (Dexmedetomidine group) (n=40) received Inj. Dexmedetomidine 0.5mcg/kg and Group N (Normal Saline group) (n=40) received 10 ml normal saline over 10 mins. Heart rate and mean arterial pressure were recorded prior to the drug administration till 10 mins after extubation. The incidence of cough was monitored during extubation. Any possible side effects of study drugs were recorded. Results Age, gender, physical status, weight, duration of surgery, baseline heart rate and mean arterial pressure were comparable between the groups. There was statistically significant difference (p < 0.05) in heart rate and mean arterial pressure between the groups after 5 mins of study drug administration and then throughout the study period. Using four point scale for coughing during extubation, 10% of Group D and 50% of Group N had minimal cough, 22.5% of Group N and 2.5% of Group D had moderate cough. Conclusion Finding suggests that intravenous dexmedetomidine before extubation significantly attenuates hemodynamic and airway responses during extubation.

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