scholarly journals Changes of indices of the oxygen-transport state, depending on periodization of the ischemic cerebral stroke

2019 ◽  
Vol 86 (10) ◽  
pp. 51-56
Author(s):  
K. V. Serikov ◽  
L. M. Smyrnova
Keyword(s):  
Oxygen Transport ◽  
Intensive Therapy ◽  
Neurological Symptoms ◽  
Cerebral Stroke ◽  
Central Hemodynamics ◽  
Cerebral Tissue ◽  
Acute Period ◽  
Oxygen Budget ◽  
Oxygen Delivery Index ◽  
Tissue Oedema

Objective. To elaborate a clinico-pathogenetic periodization of ischemic cerebral stroke, depending on changes of the oxygen-transport state indices in critically ill patents, suffering the ischemic cerebral stroke on background of conduction of complex intensive therapy. Materials and methods. Into the investigation 75 patients, suffering ischemic cerebral stroke, ageing 41 - 77 yrs, were included, in whom the indices of oxygen-transport state and severity of neurological symptoms on background of complex intensive therapy were studied. Depending on severity of neurologic symptoms, three similar groups of patients were formed (25 patients in every one), suffering mild, middle-severe and severe ischemic cerebral stroke, in which the disease severity was determined in accordance to the National Institute of Health Stroke Scale. Results. On background of the complex intensive therapy conduction the duration of the most acute period in mild ischemic stroke have constituted 3 days, in a middle-severe - 4 days, and in a severe one - 7 days. Tendency towards minimization of neurologic deficiency was noted, if parameters of central hemodynamics, the oxygen budget and the cognition level were stabilized during 2 days. Simultaneously the cardiac index values for all groups of patients have been situated in a range of (2.99 ± 0.20) l × min-1 × m-2, the oxygen delivery index have exceeded (509 ± 34) ml × min-1 × m-2. The restored level of neurological symptoms have not a tendency towards improvement or was stable during several days in accordance to data of the National Institute of Health Stroke Scale. The restored level of neurological symptoms had a tendency to improvement or staying during several days stable in accordance to indices of scales of National Institute of Health and Comas Glasgow, than a progressive staged improvement began. Conclusion. Normalization during 2 days of the oxygen-transport state indices without neurological symptoms progression constitutes a criterion of conclusion of the most acute period of the disease in patients, suffering mild, middle-severe and severe ischemic cerebral stroke. The restored due to intensive therapy during 48 h the oxygen-transport state without progressing of neurological symptoms in patients, suffering ischemic cerebral stroke, witnesses lowering of the cerebral tissue oedema and restoration of the autoregulation processes.

scholarly journals The role of metabolic adaptation of the functional state of circulating erythron in determining the course of traumatic disease in patients with massive blood loss in polytrauma

2020 ◽  
Vol 24 (4) ◽  
pp. 689-693
Author(s):  
Yu. A. Tygai ◽  
K. G. Mikhnevich
Keyword(s):  
Blood Loss ◽  
Functional State ◽  
Oxygen Transport ◽  
Oxygen Delivery ◽  
Intensive Therapy ◽  
Metabolic Adaptation ◽  
Transfusion Therapy ◽  
Group I ◽  
Oxygen Delivery Index ◽  
Group Ii

Annotation. Metabolic adaptation of the functional state of circulating erythron is an important criterion for predicting the course of traumatic disease in patients with polytrauma, which is accompanied by heavy blood loss. The aim of the study was to increase the effectiveness of treatment of patients with polytrauma with hemorrhagic shock by developing and implementing a differentiated approach to infusion and transfusion therapy, based on elucidation of the mechanisms of systemic oxygen transport in the postoperative period. The index of erythrocyte transformation index, oxygen delivery index as a leading indicator of oxygen transport system in patients of group I who received intensive therapy according to the classical algorithm, in patients of group II who were additionally prescribed ceruloplasmin solution, in patients of group III who were additionally prescribed a solution of D-fructose-1,6-diphosphate sodium salt hydrate. To determine the functional state of erythrocytes and their ability to deform, we used the method of scanning electron microscopy. Statistical data processing was performed using Student’s t-test (for n<100) at a given level of reliability p=0.95. The statistical analysis of the obtained data revealed a probable reduction in the number of doses of heterogeneous erythrocytes received by patients with high blood loss in polytrauma in patients of group II on the background of maximum ability of erythrocytes to transform while maintaining the oxygen delivery index at a satisfactory level. In the future it is planned to study the morphofunctional parameters of erythrocytes in this group of patients.

scholarly journals Clinical and Neurological Symptoms in Acute Brain Stroke from Gender Dymorphism and Age Features

2021 ◽  
Vol 04 (10) ◽  
Author(s):  
N.M. Vakhabova ◽  
Keyword(s):  
Social Problems ◽  
Neurological Symptoms ◽  
Cerebral Stroke ◽  
Stroke Outcomes ◽  
Cerebrovascular Accidents ◽  
Clear Tendency ◽  
The World ◽  
Brain Stroke ◽  
Age Features ◽  
Acute Cerebral Stroke

To date, CVD, in particular acute cerebrovascular accidents, have a clear tendency to increase. The existing domestic and especially foreign literature testifies to the established important medical and social problems of acute cerebral stroke in the society of humanity around the world. Stroke can develop at any age, but its frequency and prevalence increase with age. About 80% of strokes occur in people over 65, with age having a major impact on stroke outcomes.

335 Evaluation of NIRS data based on theoretical analysis of oxygen transport to cerebral tissue

2008 ◽  
Vol 2008 (0) ◽  
pp. _335-1_-_335-4_
Author(s):  
Masanobu OHMORI ◽  
Kazunori OHYAMA ◽  
Toshihiro KONDO ◽  
Toshihiko SUGIURA
Keyword(s):  
Theoretical Analysis ◽  
Oxygen Transport ◽  
Cerebral Tissue ◽  
Nirs Data

Dynamics of neurological symptoms in acute period of leptospirosis

2013 ◽  
Vol 333 ◽  
pp. e601
Author(s):  
M. Barabanova ◽  
N. Svistunov ◽  
O.V. Stoyanova ◽  
V.K. Oranskaya
Keyword(s):  
Neurological Symptoms ◽  
Acute Period

scholarly journals STEP-BY-STEP THERAPY OF INTRACRANIAL HYPERTENSION IN THE ACUTE PERIOD OF SEVERE MECHANICAL TRAUMA IN CHILDREN

2018 ◽  
Vol 22 (6) ◽  
pp. 296-300
Author(s):  
Irina A. Kolykhalkina ◽  
V. G. Amcheslavsky ◽  
T. F. Ivanova ◽  
V. I. Lukyanov ◽  
L. M. Roshal
Keyword(s):  
Intracranial Hypertension ◽  
Intensive Therapy ◽  
Time Frame ◽  
Mechanical Trauma ◽  
Control Group ◽  
Acute Period ◽  
Results Of Treatment ◽  
Treatment Measures ◽  
Group Control Group ◽  
Step Therapy

Aim of the study to improve the results of treatment of children with intracranial hypertension in the acute period of severe mechanical trauma by virtue of the use of the “Protocol of step-by-step therapy” Material and methods. The article is devoted to the problem of intracranial hypertension in children with severe mechanical trauma. An analysis of 148 case histories of children with severe mechanical trauma, including brain trauma hospitalized in an intensive care unit. 27 patients out of 148 were excluded from the inclusion criteria: 6 patients (22.2%) due to the “late” admission (more than 72 hours from the time of injury); 21 patients - (77,8%) due to the persistent condition of atonic coma from the moment of trauma. 121 patients, according to indications, monitored intracranial pressure and intensive therapy of intracranial hypertension. All patients were divided into two groups: one group (the main one - 84 patients), in which the treatment was carried out according to the “Protocol of step-by-step therapy of intracranial hypertension” and approved in the Scientific Research Institute of Emergency Children’s Surgery and Traumatology, characterized by a strict sequence of treatment measures (“steps”), with clear indications for prescribing each subsequent “step” and the time frame for the duration of the “steps” taken; 2 group (control group - 37 patients), in which the treatment was carried out according to existing international guidelines for the management of patients with severe head injury. Conclusion. Comparative evaluation of treatment results showed outcomes of trauma in the main group to be better, including a statistically significantly less mortality rate (p = 0.0002, p < 0.05).

scholarly journals Usage of neurospecific peptide substance “semax” in acute period of ischemic insult

1997 ◽  
Vol XXIX (3-4) ◽  
pp. 32-38
Author(s):  
Е. I. Gusev ◽  
V. I. Skvortsova ◽  
Е. J. Zhuravleva ◽  
А. V. Vanichkin
Keyword(s):  
Comparison Group ◽  
Intensive Therapy ◽  
Control Group ◽  
Motor Disorders ◽  
Synthetic Analogue ◽  
Medicinal Substance ◽  
Ischemic Insult ◽  
Acute Period ◽  
Clinical Scales

In 30 patients being in acute period of hemispheric ischemic insult, investigation of medicinal substance Semax (synthetic analogue ACTH 4-10) was performed. Control group was made up of 80 patients with analogous in severty and localization of ischemic insult lesions, who received only unified therapy; the comparison group was made up of patients, receiving cerebrolysin and cronassial. 3 clinical scales of evaluation in points were used, as well as neurophysiologic control, uncluding EEG with toposelective Cartogram EEG, repeated investigation of somatosensoric induced potentials of brain with their charting. It was established that inclusion of Semax into intensive therapy complex for acute hemispheric ischemic insult reliably enfluences the rates of disturbed neurologic functions restoration, speeding regress of brain and focal disorders, especially motor disorders.

scholarly journals The Specific Features of Oxygen Transport in the Acute Period of Ischemic Stroke

2010 ◽  
Vol 6 (2) ◽  
pp. 30
Author(s):  
K. V. Lukashev ◽  
A. Z Valiakhmedov ◽  
Yu. A. Churlyaev ◽  
N. N, Epifantseva ◽  
T. I. Borshchikova ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Oxygen Transport ◽  
Acute Period

scholarly journals COMPARISON OF THE DYNAMIC CHANGES OF AMINO ACID BLOOD PLASMA SPECTRUM IN PATIENTS WITH THE PRIMARY CEREBRAL ISCHEMIC STROKE DEPENDING ON THE POSTAPOPLECTIC SPASTICITY DEVELOPMENT IN THE RECOVERY PERIOD

2016 ◽  
Vol 3 ◽  
pp. 17-23
Author(s):  
Anzhelika Payenok ◽  
Maria Bilobryn ◽  
Iryna Mitelman
Keyword(s):  
Ischemic Stroke ◽  
Blood Plasma ◽  
Recovery Period ◽  
Control Group ◽  
Cerebral Stroke ◽  
Early Recovery ◽  
Dynamic Changes ◽  
Acute Period ◽  
Cerebral Ischemic Stroke ◽  
Cerebral Ischemic

The aim of research was to reveal the dynamic changes of the level of excitatory and inhibitory neuroamino acids in patients with the primary cerebral ischemic stroke depending on postapoplectic spasticity presence at the end of the early recovery period. For this aim was studied the concentration of excitatory and inhibitory neuroamino acids in the blood plasma in first 72 hours in 97 patients with the primary ischemic cerebral stroke depending on postapoplectic spasticity on the sixth month after ischemic event. The control group included 15 patients with diagnosed chronic cerebral ischemia. In the result of research we revealed that the common sign for the two groups (with spasticity on the sixth month and without it) was the reliable rise of the level of excitatory amino acids comparing with the control. In patients without spasticity the heightened level of excitatory neurotransmitters in the most acute period of ischemic cerebral stroke was attended with the heightened level of inhibitory neuroamino acids. The distinctive feature of patients with postapoplectic spasticity was the decreased or stable level of transmitters of inhibitory action. During 6th moth after ischemic stroke was detected the rise of all studied neuroamino acids in patients with spasticity unlike to the ones without spasticity who were characterized only with the rise of taurine level and decrease of glycine and aspartate levels. So, the received results allow assume the insufficient activation of the inhibitory neuroamino acids system in the most acute period of the ischemic stroke in certain category of patients that in future are inclined to the spasticity development after stroke.

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