Factors affecting the effectiveness of rehabilitation in patients in the acute period of cerebral stroke

Author(s):  
L.B. Novikova ◽  
A.P. Akopyan ◽  
K.M. Sharapova
2016 ◽  
Vol 3 ◽  
pp. 17-23
Author(s):  
Anzhelika Payenok ◽  
Maria Bilobryn ◽  
Iryna Mitelman

The aim of research was to reveal the dynamic changes of the level of excitatory and inhibitory neuroamino acids in patients with the primary cerebral ischemic stroke depending on postapoplectic spasticity presence at the end of the early recovery period. For this aim was studied the concentration of excitatory and inhibitory neuroamino acids in the blood plasma in first 72 hours in 97 patients with the primary ischemic cerebral stroke depending on postapoplectic spasticity on the sixth month after ischemic event. The control group included 15 patients with diagnosed chronic cerebral ischemia. In the result of research we revealed that the common sign for the two groups (with spasticity on the sixth month and without it) was the reliable rise of the level of excitatory amino acids comparing with the control. In patients without spasticity the heightened level of excitatory neurotransmitters in the most acute period of ischemic cerebral stroke was attended with the heightened level of inhibitory neuroamino acids. The distinctive feature of patients with postapoplectic spasticity was the decreased or stable level of transmitters of inhibitory action. During 6th moth after ischemic stroke was detected the rise of all studied neuroamino acids in patients with spasticity unlike to the ones without spasticity who were characterized only with the rise of taurine level and decrease of glycine and aspartate levels. So, the received results allow assume the insufficient activation of the inhibitory neuroamino acids system in the most acute period of the ischemic stroke in certain category of patients that in future are inclined to the spasticity development after stroke.


2002 ◽  
Vol XXXIV (3-4) ◽  
pp. 59-60
Author(s):  
E. I. Bogdanov ◽  
F. V. Тахавиева

The problem of rehabilitation treatment of patients who have suffered a cerebral stroke is extremely relevant due to its widespread prevalence, high rates of mortality and disability. One of the main reasons for persistent disability are, along with impaired speech function, psychological and social maladjustment, impaired motor functions of patients.


2021 ◽  
Vol 29 (2) ◽  
pp. 201-212
Author(s):  
Andrey E. Kulchikov ◽  
Sergey G. Morozov ◽  
Rashit S. Musin ◽  
Elena A. Grinenko

BACKGROUND: The development of immunosuppression in the acute phase of cerebral stroke may lead to infectious and inflammatory complications. However, data on the functional activity of macrophages are insufficient to understand the pathogenesis of stroke. AIM: This study aimed to investigate the functional activity of macrophages in the acute period of experimental cerebral stroke (ECS) of different severities. MATERIALS AND METHODS: In an experimental study on 45 Wistar rats, the functional and spontaneous metabolic activity of macrophages in the spleen and abdominal cavity and the induced metabolic activity of peritoneal macrophages were evaluated through the reduction of nitro blue tetrazolium via spectrophotometry. The spontaneous and induced adhesive activity and the inhibition of the modified adhesive activity of peritoneal macrophages were examined via crystal violet staining by using a colorimetric method. ECS was modeled by the rotational movements of mandrel-knife inserted into the region of capsula interna (c.i.) on the left by guiding a needlecannula with the subsequent damage of vessels and the formation of mild (local incision of vessels in the region of c.i.), moderate (additional introduction of autologous blood in the area of c.i.), and severe (cutting of vessels from c.i. to pia mater with the subsequent introduction of autologous blood into the damaged area) hemorrhage. Data were evaluated in 72 h after different severities of ECS were modeled. RESULTS: In 72 h after ECS with different severities was modeled, the functional and spontaneous metabolic activity of splenic macrophages significantly decreased compared with those in the control group. The functional, spontaneous, and induced metabolic activity of peritoneal macrophages significantly reduced compared with those in the control group. The adhesive activity of peritoneal macrophages significantly increased compared with that of the control group. These disorders exacerbated in animal models with a more severe degree of stroke. CONCLUSION: In the acute period of ECS, the functional activity of macrophages decreased, whereas their adhesive activity increased. These phenomena enhanced in more severe models of stroke.


2014 ◽  
Vol 2 (3) ◽  
pp. 452-455 ◽  
Author(s):  
Kristin Grigorova-Petrova ◽  
Daniela Lubenova ◽  
Antoaneta Dimitrova ◽  
Dimo Baldaranov ◽  
Julia Lozeva

BACKGROUND AND PURPOSE: Clinical practice guidelines for patients with stroke recommend early stroke rehabilitation at acute stroke unit care. The purpose of the study is to determine the feasibility of the application of feedback breathing device for respiratory training during the acute period in patients with ischemic cerebral stroke and appropriate program of physical therapy.MATERIAL AND METHODS: Seven patients in acute period – not later than 48 hours after the accident with light to moderate stroke severity under the NIHSS scale. The applied study methods are the following: functional respiratory evaluation, inspiratory capacity with incentive spirometer device, assessing diaphragmatic movement by ultrasonography.RESULTS: Better results in Forced Vital Capacity, Peak Expiratory Flow, inspiratory capacity and ultrasonography have been observed.CONCLUSION: An early targeted impact on respiratory disorders in patients with ischemic cerebral stroke is applicable. To determine the clinical significance larger studies are needed.


2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Ramez Khatab ◽  
Neamatallah Gomaa ◽  
Asmaa Saaed

Context: Stroke associated with high mortality, morbidity and creates a significant and enduring impact on patients, their families, and the wider society. Aim: assess the nurses' performance for patients with cerebral stroke during first golden hours through assessing nurses' level of knowledge regarding cerebral stroke and their nursing management during first golden hours, assessing level of nurses' practices for patients with cerebral stroke during first golden hours and assess factors that affect nurses' performance in management of patients with cerebral stroke during first golden hours. Methods: A descriptive exploratory study design used to achieve the aim of this study. The study recruited a convenient sample of 80 nurses. Data collected from Intensive Care Units at Ain Shams University and the specialized hospital affiliated with Ain Shams University in Egypt. Two tools used for data collection: Nurses self-administered questionnaire, and nurses’ performance observational checklist. Results: This study revealed that 63.75% had an unsatisfactory level of knowledge, 68.8% had inadequate performance, and there were human and non-human resource factors, both affect negatively on nurses' performance in the management of patients with cerebral stroke. Conclusion: The study concluded that there was an unsatisfactory score of nurses' knowledge and practice and there were a human and non-human resource factors that affect negatively on nurse’s performance. Based on these findings the study recommended that periodic education programs must be developed for nurses about management of patients with cerebral stroke during first golden hours, and prospectively follow up studies are needed to develop and refine interventions.


2019 ◽  
Vol 86 (10) ◽  
pp. 51-56
Author(s):  
K. V. Serikov ◽  
L. M. Smyrnova

Objective. To elaborate a clinico-pathogenetic periodization of ischemic cerebral stroke, depending on changes of the oxygen-transport state indices in critically ill patents, suffering the ischemic cerebral stroke on background of conduction of complex intensive therapy. Materials and methods. Into the investigation 75 patients, suffering ischemic cerebral stroke, ageing 41 - 77 yrs, were included, in whom the indices of oxygen-transport state and severity of neurological symptoms on background of complex intensive therapy were studied. Depending on severity of neurologic symptoms, three similar groups of patients were formed (25 patients in every one), suffering mild, middle-severe and severe ischemic cerebral stroke, in which the disease severity was determined in accordance to the National Institute of Health Stroke Scale. Results. On background of the complex intensive therapy conduction the duration of the most acute period in mild ischemic stroke have constituted 3 days, in a middle-severe - 4 days, and in a severe one - 7 days. Tendency towards minimization of neurologic deficiency was noted, if parameters of central hemodynamics, the oxygen budget and the cognition level were stabilized during 2 days. Simultaneously the cardiac index values for all groups of patients have been situated in a range of (2.99 ± 0.20) l × min-1 × m-2, the oxygen delivery index have exceeded (509 ± 34) ml × min-1 × m-2. The restored level of neurological symptoms have not a tendency towards improvement or was stable during several days in accordance to data of the National Institute of Health Stroke Scale. The restored level of neurological symptoms had a tendency to improvement or staying during several days stable in accordance to indices of scales of National Institute of Health and Comas Glasgow, than a progressive staged improvement began. Conclusion. Normalization during 2 days of the oxygen-transport state indices without neurological symptoms progression constitutes a criterion of conclusion of the most acute period of the disease in patients, suffering mild, middle-severe and severe ischemic cerebral stroke. The restored due to intensive therapy during 48 h the oxygen-transport state without progressing of neurological symptoms in patients, suffering ischemic cerebral stroke, witnesses lowering of the cerebral tissue oedema and restoration of the autoregulation processes.


Author(s):  
F. A. Heckman ◽  
E. Redman ◽  
J.E. Connolly

In our initial publication on this subject1) we reported results demonstrating that contrast is the most important factor in producing the high image quality required for reliable image analysis. We also listed the factors which enhance contrast in order of the experimentally determined magnitude of their effect. The two most powerful factors affecting image contrast attainable with sheet film are beam intensity and KV. At that time we had only qualitative evidence for the ranking of enhancing factors. Later we carried out the densitometric measurements which led to the results outlined below.Meaningful evaluations of the cause-effect relationships among the considerable number of variables in preparing EM negatives depend on doing things in a systematic way, varying only one parameter at a time. Unless otherwise noted, we adhered to the following procedure evolved during our comprehensive study:Philips EM-300; 30μ objective aperature; magnification 7000- 12000X, exposure time 1 second, anti-contamination device operating.


Author(s):  
Christine M. Dannels ◽  
Christopher Viney

Processing polymers from the liquid crystalline state offers several advantages compared to processing from conventional fluids. These include: better axial strength and stiffness in fibers, better planar orientation in films, lower viscosity during processing, low solidification shrinkage of injection moldings (thermotropic processing), and low thermal expansion coefficients. However, the compressive strength of the solid is disappointing. Previous efforts to improve this property have focussed on synthesizing stiffer molecules. The effect of microstructural scale has been overlooked, even though its relevance to the mechanical and physical properties of more traditional materials is well established. By analogy with the behavior of metals and ceramics, one would expect a fine microstructure (i..e. a high density of orientational defects) to be desirable.Also, because much microstructural detail in liquid crystalline polymers occurs on a scale close to the wavelength of light, light is scattered on passing through these materials.


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