Clinical and Histologic Evaluation of Using Block Xenograft Combined With Leukocyte-Platelet Rich Fibrin (L-PRF) Versus Intraoral Autogenous Bone Block Graft With L-PRF in Treating Localized Ridge Defects: A Randomized Clinical Trial

Background: Augmentation of vertical bone defects remains the corner stone in periodontal tissue engineering. The amount and quality of alveolar bone available in all dimensions affects the success of dental implants for restoration of edentulous areas. Adequate and healthy bone supports the degree of osseointegration which in turn affects the long-term success of oral implants. The primary aim of the study was to histologically evaluate autogenous block grafts versus synthetic block grafts for the treatment of atrophic vertical and horizontal bony defects (Siebert Class III) in the anterior esthetic zone of the mouth. The secondary aim was to clinically and radiographically evaluate the outcomes of the procedure. Methods: This was a randomized controlled clinical study with a statistically determined sample size of 10 patients per group and a total of 20 patients in both groups. Patients with vertical and horizontal bone loss were enrolled from the Department of Oral Medicine, Periodontology, and Oral Diagnosis of Ain Shams University and Misr International University. Bone augmentation procedures were performed using two techniques: autogenous bone block graft and xenograft bone block graft both with leukocyte-platelet rich fibrin (L-PRF). Results: Both autogenous and xenograft blocks in conjunction with L-PRF had a significant effect on vertical bone augmentation in cases of atrophic ridges in the esthetic region. Conclusion: Both autogenous and xenograft bone blocks in conjunction with L-PRF have a significant effect on vertical bone augmentation in cases of atrophic ridges in the esthetic region.

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Long-term results of mandibular reconstruction with autogenous bone grafts and oral implants after tumor resection

Clinical Oral Implants Research ◽

10.1111/j.1600-0501.2008.01542.x ◽

2008 ◽

Vol 19 (10) ◽

pp. 1074-1080 ◽

Cited By ~ 72

Author(s):

Matteo Chiapasco ◽

Giacomo Colletti ◽

Eugenio Romeo ◽

Marco Zaniboni ◽

Roberto Brusati

Keyword(s):

Tumor Resection ◽

Bone Grafts ◽

Mandibular Reconstruction ◽

Long Term Results ◽

Autogenous Bone ◽

Oral Implants ◽

Autogenous Bone Grafts

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Current approach to bone augmentation with allogeneic cortical graft: A case report

International Dental Research ◽

10.5577/intdentres.2021.vol11.suppl1.44 ◽

2021 ◽

Vol 11 (Suppl. 1) ◽

pp. 299-302

Author(s):

Utku Nezih Yılmaz ◽

Fatma Eriş Derkuş

Keyword(s):

Case Report ◽

Dental Implant ◽

Soft Tissues ◽

Alveolar Bone ◽

Healing Process ◽

Bone Defects ◽

Current Approach ◽

Autogenous Bone ◽

Bone Augmentation ◽

Alveolar Crest

Aim: Today, dental implant applications have become the most preferred option in the treatment of tooth deficiencies. Long-term successful results in dental implant applications depend largely on the volume and quality of the hard and soft tissues in the relevant region. Insufficient soft tissues and alveolar crest resorption complicate implant applications. Grafts and additional surgical procedures are required to compensate for resorption and to provide bone augmentation. Shell technique, one of the augmentation methods used in the treatment of alveolar bone defects, is an important procedure for guided bone regeneration. The purpose of this case report is to describe the treatment of vertical and horizontal bone loss with the Shell technique using allogeneic cortical grafts. Methodology: A 58-year-old female patient without any systemic disease was admitted to our clinic with the complaint of tooth loss in the right posterior mandibular region. In the intraoral and radiological examinations, it was determined that the bone volume in the relevant region was not sufficient for dental implant. Two-stage surgical treatment was planned for the patient. First, vertical and horizontal bone defects were augmented with allogeneic cortical graft application under local anesthesia. After the healing process, dental implants were placed in the sufficient volume of the alveolar bone and the patient's treatment was completed. Conclusion: Allogeneic grafts in the treatment of alveolar crest defects; it is a good alternative to autogenous bone grafts,there is no need for a second surgical field and the resulting reduction in morbidity. How to cite this article: Eriş Derkuş F, Yılmaz UN. Current approach to bone augmentation with allogeneic cortical graft: A case report. Int Dent Res 2021;11(Suppl.1):299-302. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.44 Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation

BioMed Research International ◽

10.1155/2013/638043 ◽

2013 ◽

Vol 2013 ◽

pp. 1-13 ◽

Cited By ~ 20

Author(s):

Qi Li ◽

Shuang Pan ◽

Smit J. Dangaria ◽

Gokul Gopinathan ◽

Antonia Kolokythas ◽

...

Keyword(s):

Tissue Regeneration ◽

Alveolar Bone ◽

Periodontal Regeneration ◽

Principal Component ◽

Nodule Formation ◽

Bone Augmentation ◽

Pilot Studies ◽

Platelet Rich Fibrin ◽

Lineage Differentiation ◽

Osteogenic Lineage

In the present study we have determined the suitability of platelet-rich fibrin (PRF) as a complex scaffold for periodontal tissue regeneration. Replacing PRF with its major component fibrin increased mineralization in alveolar bone progenitors when compared to periodontal progenitors, suggesting that fibrin played a substantial role in PRF-induced osteogenic lineage differentiation. Moreover, there was a 3.6-fold increase in the early osteoblast transcription factor RUNX2 and a 3.1-fold reduction of the mineralization inhibitor MGP as a result of PRF application in alveolar bone progenitors, a trend not observed in periodontal progenitors. Subcutaneous implantation studies revealed that PRF readily integrated with surrounding tissues and was partially replaced with collagen fibers 2 weeks after implantation. Finally, clinical pilot studies in human patients documented an approximately 5 mm elevation of alveolar bone height in tandem with oral mucosal wound healing. Together, these studies suggest that PRF enhances osteogenic lineage differentiation of alveolar bone progenitors more than of periodontal progenitors by augmenting osteoblast differentiation, RUNX2 expression, and mineralized nodule formation via its principal component fibrin. They also document that PRF functions as a complex regenerative scaffold promoting both tissue-specific alveolar bone augmentation and surrounding periodontal soft tissue regeneration via progenitor-specific mechanisms.

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Autogenous Chin Block Grafts in the Aesthetic Zone: A 20-Year Follow-Up Case Report

Case Reports in Dentistry ◽

10.1155/2020/6525797 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Carlo Maiorana ◽

Susanna Ferrario ◽

Pier Paolo Poli ◽

Mattia Manfredini

Keyword(s):

Autogenous Bone ◽

Bone Augmentation ◽

Reliable Technique ◽

Implant Placement ◽

Osseointegrated Implants ◽

Clinical And Radiological Outcome ◽

The Aesthetic ◽

Autogenous Bone Grafts

The successful use of osseointegrated implants in the treatment of partial or complete edentulism requires a sufficient bone support. Whenever rehabilitation in atrophic edentulous areas is needed, bone augmentation procedures are recommended. The aim is to provide adequate amount of supporting bone to achieve a prosthetically guided implant placement. This in turn leads to functional and aesthetic improvements that can be maintained on the long term. Bone grafting of the atrophic site can be performed either prior to implant placement or at the time of implantation. Irrespective of the timing, bone augmentation by means of autogenous bone grafts is a reliable technique, as confirmed by several studies. On the other hand, long-term evidence on the use of autogenous chin block grafts in preprosthetic implant surgery is still scarce. Thus, the purpose of the present case is to report the 20-year clinical and radiological outcome of autogenous chin block grafts used to augment a bilateral defect due to agenesis of the upper lateral incisors for implant placement purposes.

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Particulate Coral Hydroxyapatite Sheltered by Titanium Mesh for Localized Alveolar Rehabilitation After Onlay Graft Failure: A Case Report

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-17-00109 ◽

2018 ◽

Vol 44 (2) ◽

pp. 147-152 ◽

Cited By ~ 1

Author(s):

Miao Zhou ◽

Shu-yi Li ◽

Hendrik Terheyden ◽

Shuai-shuai Cao ◽

Yue-juan Che ◽

...

Keyword(s):

Computerized Tomography ◽

Graft Failure ◽

Alveolar Bone ◽

Wound Dehiscence ◽

Bone Block ◽

Bone Augmentation ◽

Titanium Mesh ◽

Efficient Treatment ◽

Onlay Graft ◽

Autologous Bone

Reconstruction of bone loss in the alveolar ridge has long been challenging. Autologous bone grafts are considered as the “golden standard,” while little research has focused on how to repair pronounced alveolar bone defects after autologous bone graft failure. The aim of this study was to detail a method based on the titanium mesh technique coupled with particulate coral hydroxyapatite to solve the onlay graft failure. With bone deficiency in the No. 11 and No. 24–25 regions, we harvested 2 autologous bone blocks for reconstruction. Two weeks after transplantation, the graft in the No. 11 region had healed uneventfully, while the graft in the anterior mandible became infected because of soft tissue dehiscence. After removal of the failed autologous bone block, pure coral hydroxyapatite stabilized within titanium mesh was used for alveolar rehabilitation. Six months later, the width of the local alveolar bone was evaluated. After the titanium mesh was removed, a biopsy was performed to study bone regeneration by micro computerized tomography and histology, following by a standard Straumann implant insertion. Although there was wound dehiscence 14 days after bone augmentation, repeated local rinsing and anti-inflammation therapy controlled the inflammatory reaction. The total horizontal bone gain was 4.2 ± 0.5 mm. Micro computerized tomography revealed that the closer the coral hydroxyapatite was to the host bone, the more was resorbed and the more bone regenerated. Histology showed mature lamellar bone structures, with evident residual coral hydroxyapatite. A 3-year follow-up revealed stable bone around the dental implant and successful function of the implant-born prosthesis. This study proposes that the method of particulate coral hydroxyapatite sheltered by titanium mesh is a promising solution in handling alveolar bone augmentation failure. More cases are needed for further research to form an efficient treatment procedure.

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Guided Bone Regeneration, Platelet Rich Plasma and Low-Intensity Ultrasound Irradiation for Dental Implants

Advances in Science and Technology ◽

10.4028/www.scientific.net/ast.49.171 ◽

2006 ◽

Vol 49 ◽

pp. 171-180 ◽

Cited By ~ 3

Author(s):

Kuniteru Nagahara ◽

Toshiichiro Tanabe ◽

Noriaki Ito ◽

Motohiko Nagayama ◽

Kota Takagi ◽

...

Keyword(s):

Bone Formation ◽

Bone Regeneration ◽

Dental Implant ◽

Platelet Rich Plasma ◽

Guided Bone Regeneration ◽

Autogenous Bone ◽

Bone Block ◽

Bone Augmentation ◽

Basic Study ◽

Low Intensity

Because a concept of an osteointegrated dental implant system was established, prognosis of a dental implant at treatment improved and the treatment of restoration for missing teeth was changed. However, a dental implant treatment into atrophic jaw bone requires bone augmentation, obviously. At this time, we studied for the purpose of establishing the evidence of each method for clinical application of these bone augmentation method, such as guided bone regeneration (GBR), and autogenous bone block graft (BBG). In addition, we pursued the basic study of the evidence about the bone formation with platelet rich plasma (PRP) which recognized the availability in clinic. Furthermore, we present the results of basic studies which we tested for the purpose of applying a low-intensity pulse ultrasound (LIPU) irradiation applied to a fracture treatment in orthopedics area to intra-oral area, specially the condition after implant placement. In the results of comparison with GBR site and BBG, the differences of labeling bands were observed with a fluorescence microscopy. There was much labeling bands on GBR sections in comparison with BBG. This meaning that the bone remodeling around implants at GBR site was more active than BBG site. And the new bone formation by PRP was identified on soft X-ray graphically at first week after PRP applied mandible bone defect (experimental side). At same region of first week specimen, we confirmed positive reactions of platelet derived growth factor

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Gene and Cell Therapy in Dental Tissue Regeneration

10.5772/intechopen.97757 ◽

2021 ◽

Author(s):

Juan Andrés de Pablo ◽

Luis Javier Serrano ◽

Mariano García-Arranz ◽

Luis Romeu ◽

Antonio Liras

Keyword(s):

Cell Therapy ◽

Bone Morphogenetic Proteins ◽

Alveolar Bone ◽

Three Dimensional ◽

Dental Practice ◽

Dental Tissue ◽

Advanced Therapies ◽

Medical Advances

Advanced therapies hold substantial promise for the treatment of periodontal conditions. Gene therapy has the potential to transfer “therapeutic” genes, which express proteins such as bone morphogenetic proteins, osteoprotegerin, and tissue nonspecific alkaline phosphatase, which is deficient in patients with hypophosphatasia, a condition that affects mineralization of teeth and bone. Transferred genes may also express platelet-derived growth factor, which modulates the growth of periodontal tissue and the alveolar bone. As regards cell therapy, several clinical trials have shown that mesenchymal stem cells, when used with different kinds of scaffolds to enable the required three-dimensional environment, possess a bone regeneration potential that is particularly useful in such disorders as osteoporosis and osteonecrosis, or for regenerating alveolar bone (osseointegration) prior to placing a dental implant. However, much work is still required before these new therapies become true alternatives in routine clinical dental practice. Medical advances require investments, which are usually influenced by the priorities of both politicians and society at large. This will contribute to promoting innovation, efficient treatments, medium- and long-term savings, and a higher quality of life.

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Intentıonal reımplantatıon of hopeless teeth: Cases serıes

Archives of Surgery and Clinical Research ◽

10.29328/journal.ascr.1001053 ◽

2020 ◽

Vol 4 (2) ◽

pp. 047-050

Author(s):

Şen Dilek Özkan ◽

Irız Betül ◽

Atay Ümmühan Tekin ◽

Öncü Elif

Keyword(s):

Alveolar Bone ◽

Class Iii ◽

Anterior Teeth ◽

Reinforced Composite ◽

Periodontal Destruction ◽

Bone Gain ◽

Periodontal Attachment Loss ◽

Term Maintenance ◽

Functional Complaints

Intentional replantation is an alternative for the treatment of advanced periodontal destruction of the anterior teeth. Systemically healthy three female patient was referred to our clinic with functional complaints. Diagnosis were chronic periodontitis and class III mobility was noted at the mandibular incisors with complete periodontal attachment loss. After phase I periodontal treatment periodontally involved teeth were extracted, endodontic treatment accomplished, the teeth were replanted and fixed to its place with fiber reinforced composite splint. At the end of 2 years tooth was in function with alveolar bone gain. Intentional replantation provided long-term maintenance of patient’s own teeth.

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Efficacy of Platelet-Rich Fibrin in Secondary Cleft Alveolar Bone Grafting

Craniomaxillofacial Trauma & Reconstruction Open ◽

10.1055/s-0039-1678672 ◽

2019 ◽

Vol 3 (1) ◽

pp. s-0039-1678672 ◽

Cited By ~ 1

Author(s):

Anil Kumar Desai ◽

Niranjan Kumar ◽

Punit Dikhit ◽

Srikanth B. Koikude ◽

Saurav Bhaduri

Keyword(s):

Bone Grafting ◽

Alveolar Bone ◽

Iliac Bone ◽

Autogenous Bone ◽

Platelet Rich Fibrin ◽

Alveolar Bone Grafting ◽

Osteogenic Effect ◽

Group 2 ◽

Secondary Alveolar Bone Grafting ◽

Group 1

The main objective of this article is to evaluate the efficacy of platelet-rich fibrin (PRF) for secondary alveolar bone grafting. Patients between 9 and 14 years of age were included in study and were divided in two groups: Group 1—iliac bone with PRF and group 2—iliac bone without PRF. Radiographic assessment was done preoperatively, immediate postoperatively, and at 3, 6, and 9 months, respectively. Vertical bone height was assessed using 4-point scale. In group 1, 14 patients showed grade 1 resorption at 3 months and at 6 and 9 months all patients showed grade 1 resorption. In group 2, 16 patients had grade 1 resorption at 3 months, 2 patients had grade 2 resorption at 6 months, and 6 patients had grade 2 resorption at 9 months. Use of PRF growth factor with autogenous bone results in greater osteogenic effect which increases new bone regeneration and better wound healing.

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