Profil Pasien Leukemia Anak di RSUD Arifin Achmad Provinsi Riau Periode Tahun 2013-2014

2017 ◽  
Vol 9 (2) ◽  
pp. 78
Author(s):  
Fridayenti Fridayenti ◽  
Huriatul Masdar ◽  
Sherly Asriani
Keyword(s):  
Bone Marrow ◽  
Acute Leukemia ◽  
Medical Records ◽  
Blood Smear ◽  
Malignant Neoplasm ◽  
Age Group ◽  
Normal Bone Marrow ◽  
Hematologic Disease ◽  
Normal Bone ◽  
B Lineage

Leukemia is a malignancy of hematologic disease characterized by replacement of normal bone marrow by abnormalblood cells. Malignant neoplasm that most common in children. The aim of this study is to describe profiles ofleukemia in children in Arifin Achmad General Hospital period 2013-2014. This is a descriptive retrospective study.The data was used 48 medical records of child with leukemia. The highest frequency of child with leukemia wasfound in the age group of 5-9 years old (39.5%), the most frequent gender was male (62.5%) and mostly come fromPekanbaru (20.8%). Based on pheripheral blood smear, acute leukemia was found in 31.3 %, pancytopenia 22.9%,normocyitic anemia 18,8, hypocromic anemia 16.7% and neutropenia 2%. Based on morphologic of bone marrowALL was found in 79.2%, AML 10.4%, CML 8.3% and 2% analyzing was not included in leukemia. There are only15 patients having immunophenotyping assesment, 86.6% are ALL B-lineage, 6.7% are AML and 6.7% result wasnot sensitive to any leukemia marker.

Anemia: Production Defects Generally Associated with Marrow Aplasia or Replacement

2017 ◽  
Author(s):  
Nancy Berliner ◽  
John M Gansner
Keyword(s):  
Bone Marrow ◽  
Differential Diagnosis ◽  
Aplastic Anemia ◽  
Blood Smear ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Normal Bone Marrow ◽  
Normal Bone ◽  
Red Cell Aplasia

This review focuses on anemia resulting from production defects generally associated with marrow aplasia or replacement. The definition, epidemiology, etiology, pathogenesis, diagnosis, differential diagnosis, management, complications, and prognosis of the following production defects are discussed: Acquired aplastic anemia and acquired pure red cell aplasia. Figures depict a leukoerythroblastic blood smear, a biopsy comparing normal bone marrow and bone marrow showing almost complete aplasia, and a marrow smear. A table lists the causes of aplastic anemia. This review contains 3 figures; 1 table; 108 references.

scholarly journals Expression of the three myeloid cell-associated immunoglobulin G Fc receptors defined by murine monoclonal antibodies on normal bone marrow and acute leukemia cells

Blood ◽  
1989 ◽  
Vol 73 (7) ◽  
pp. 1951-1956
Author(s):  
ED Ball ◽  
J McDermott ◽  
JD Griffin ◽  
FR Davey ◽  
R Davis ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Monoclonal Antibodies ◽  
Acute Leukemia ◽  
Cell Sorting ◽  
Lymphoblastic Leukemia ◽  
Mononuclear Phagocytes ◽  
Leukemic Cells ◽  
Leukemia Cells ◽  
Normal Bone Marrow ◽  
Normal Bone

Monoclonal antibodies (MoAbs) have been prepared recently that recognize the three cell-surface receptors for the Fc portion of immunoglobulin (Ig), termed Fc gamma RI (MoAb 32.2), Fc gamma R II (MoAb IV-3), and Fc gamma R III (MoAb 3G8) that are expressed on selected subsets of non-T lymphocyte peripheral blood leukocytes. In the blood, Fc gamma R I is expressed exclusively on monocytes and macrophages, Fc gamma R II on granulocytes, mononuclear phagocytes, platelets, and B cells, and Fc gamma R III on granulocytes and natural killer (NK) cells. We have examined the expression of these molecules on normal bone marrow (BM) cells and on leukemia cells from the blood and/or BM in order to determine their normal ontogeny as well as their distribution on leukemic cells. BM was obtained from six normal volunteers and from 170 patients with newly diagnosed acute leukemia. Normal BM cells were found to express Fc gamma R I, II, and III with the following percentages: 40%, 58%, and 56%, respectively. Cell sorting revealed that both Fc gamma R I and Fc gamma R II were detectable on all subclasses of myeloid precursors as early as myeloblasts. Cell sorting experiments revealed that 66% of the granulocyte-monocyte colony-forming cells (CFU-GM) and 50% of erythroid burst-forming units (BFU-E) were Fc gamma R II positive with only 20% and 28%, respectively, of CFU-GM and BFU-E were Fc gamma R I positive. Acute myeloid leukemia (AML) cells expressed the three receptors with the following frequency (n = 146): Fc gamma R I, 58%; Fc gamma R II, 67%; and Fc gamma R III, 26% of patients. Despite the fact that Fc gamma R I is only expressed on monocytes among blood cells, AML cells without monocytoid differentiation (French-American-British [FAB]M1, M2, M3, M6) were sometimes positive for this receptor. However, Fc gamma R I was highly correlated with FAB M4 and M5 morphology (P less than .001). Fc gamma R II was also correlated with FAB M4 and M5 morphology (P = .003). Cells from 11 patients with acute lymphoblastic leukemia were negative for Fc gamma R I, but six cases were positive for Fc gamma R II and III (not the same patients). These studies demonstrate that Ig Fc gamma R are acquired during normal differentiation in the BM at or before the level of colony-forming units. In addition, we show that acute leukemia cells commonly express Fc gamma R.

The classification of leukaemia

2010 ◽  
pp. 4221-4228
Author(s):  
Wendy N. Erber
Keyword(s):  
Bone Marrow ◽  
Characteristic Feature ◽  
Lymph Nodes ◽  
Malignant Neoplasm ◽  
Normal Bone Marrow ◽  
Neoplastic Cells ◽  
Normal Bone ◽  
Haematopoietic Cells ◽  
Leukaemic Cells

Leukaemia is a malignant neoplasm of haematopoietic cells originating in the marrow and spreading to the blood and other tissues, such as the lymph nodes, spleen, and liver. The characteristic feature of the neoplastic cells is that they retain the ability to proliferate but fail to differentiate normally into functional haematopoietic cells. This results in replacement of the normal bone marrow by the leukaemic cells....

scholarly journals Expression of the three myeloid cell-associated immunoglobulin G Fc receptors defined by murine monoclonal antibodies on normal bone marrow and acute leukemia cells

Blood ◽  
1989 ◽  
Vol 73 (7) ◽  
pp. 1951-1956 ◽  
Author(s):  
ED Ball ◽  
J McDermott ◽  
JD Griffin ◽  
FR Davey ◽  
R Davis ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Monoclonal Antibodies ◽  
Acute Leukemia ◽  
Cell Sorting ◽  
Lymphoblastic Leukemia ◽  
Mononuclear Phagocytes ◽  
Leukemic Cells ◽  
Leukemia Cells ◽  
Normal Bone Marrow ◽  
Normal Bone

Abstract Monoclonal antibodies (MoAbs) have been prepared recently that recognize the three cell-surface receptors for the Fc portion of immunoglobulin (Ig), termed Fc gamma RI (MoAb 32.2), Fc gamma R II (MoAb IV-3), and Fc gamma R III (MoAb 3G8) that are expressed on selected subsets of non-T lymphocyte peripheral blood leukocytes. In the blood, Fc gamma R I is expressed exclusively on monocytes and macrophages, Fc gamma R II on granulocytes, mononuclear phagocytes, platelets, and B cells, and Fc gamma R III on granulocytes and natural killer (NK) cells. We have examined the expression of these molecules on normal bone marrow (BM) cells and on leukemia cells from the blood and/or BM in order to determine their normal ontogeny as well as their distribution on leukemic cells. BM was obtained from six normal volunteers and from 170 patients with newly diagnosed acute leukemia. Normal BM cells were found to express Fc gamma R I, II, and III with the following percentages: 40%, 58%, and 56%, respectively. Cell sorting revealed that both Fc gamma R I and Fc gamma R II were detectable on all subclasses of myeloid precursors as early as myeloblasts. Cell sorting experiments revealed that 66% of the granulocyte-monocyte colony-forming cells (CFU-GM) and 50% of erythroid burst-forming units (BFU-E) were Fc gamma R II positive with only 20% and 28%, respectively, of CFU-GM and BFU-E were Fc gamma R I positive. Acute myeloid leukemia (AML) cells expressed the three receptors with the following frequency (n = 146): Fc gamma R I, 58%; Fc gamma R II, 67%; and Fc gamma R III, 26% of patients. Despite the fact that Fc gamma R I is only expressed on monocytes among blood cells, AML cells without monocytoid differentiation (French-American-British [FAB]M1, M2, M3, M6) were sometimes positive for this receptor. However, Fc gamma R I was highly correlated with FAB M4 and M5 morphology (P less than .001). Fc gamma R II was also correlated with FAB M4 and M5 morphology (P = .003). Cells from 11 patients with acute lymphoblastic leukemia were negative for Fc gamma R I, but six cases were positive for Fc gamma R II and III (not the same patients). These studies demonstrate that Ig Fc gamma R are acquired during normal differentiation in the BM at or before the level of colony-forming units. In addition, we show that acute leukemia cells commonly express Fc gamma R.

Different expression of adhesion molecules on CD34+ cells in AML and B-lineage ALL and their normal bone marrow counterparts

2009 ◽  
Vol 63 (3) ◽  
pp. 192-201 ◽  
Author(s):  
M. Waele ◽  
W. Renmans ◽  
K. Jochmans ◽  
R. Schots ◽  
P. Lacor ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adhesion Molecules ◽  
Normal Bone Marrow ◽  
Normal Bone ◽  
Cd34 Cells ◽  
B Lineage

Persistence of Inhibitory Activity against Normal Bone-Marrow Cells during Remission of Acute Leukemia

1979 ◽  
Vol 301 (7) ◽  
pp. 346-351 ◽  
Author(s):  
Hal E. Broxmeyer ◽  
Elliott Grossbard ◽  
Niels Jacobsen ◽  
Malcolm A. S. Moore
Keyword(s):  
Bone Marrow ◽  
Acute Leukemia ◽  
Inhibitory Activity ◽  
Bone Marrow Cells ◽  
Normal Bone Marrow ◽  
Normal Bone ◽  
Marrow Cells

Terminal Deoxynucleotidyl Transferase Staining in acute Leukemia and Normal Bone Marrow in Routinely Processed Paraffin Sections

1994 ◽  
Vol 102 (5) ◽  
pp. 640-645 ◽  
Author(s):  
Attilio Orazi ◽  
Jenny Cotton ◽  
Cattoretti Giorgio ◽  
K. Kotylo Patricia ◽  
Karla John ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Leukemia ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Normal Bone Marrow ◽  
Paraffin Sections ◽  
Normal Bone

Growth factor receptor profile of CD34+ cells in AML and B-lineage ALL and in their normal bone marrow counterparts

2001 ◽  
Vol 66 (3) ◽  
pp. 178-187 ◽  
Author(s):  
M. De Waele ◽  
W. Renmans ◽  
K. Vander Gucht ◽  
K. Jochmans ◽  
R. Schots ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Normal Bone Marrow ◽  
Normal Bone ◽  
Cd34 Cells ◽  
Receptor Profile ◽  
B Lineage

Abnormal Expression of Receptor Tyrosine Kinase Mer in Adult Acute Leukemia.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4252-4252
Author(s):  
Lei Fan ◽  
Liqian Xie ◽  
Fei Shen ◽  
Lan Dai ◽  
Wei Xu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Flow Cytometry ◽  
T Lymphocytes ◽  
Acute Leukemia ◽  
B Lymphocytes ◽  
Receptor Tyrosine Kinase ◽  
Expression Level ◽  
Normal Bone Marrow ◽  
Rt Pcr ◽  
Normal Bone

Abstract BACKGROUND & OBJECTIVE Mer was found a proto-oncogene in some solid tumor. it belongs to Axl receptor tyrosine kinase family. This study was to detect Mer expression in 57 adult acute leukemia patients’ bone marrow (32 AML and 25 ALL patients) and normal control. Methods Flow cytometry with anti-CD15, CD3, CD19 and CD14 antibody were used to detect Mer expression on granulocytes, T-lymphocytes, B-lymphocytes and monocytes in normal bone marrow. Mer expression on leukemia cells of patients’ bone marrow samples were also analysed by flow cytometry, and RT-PCR was used to verify parts of Mer mRNA level expreesion in mononuclearcell of bone marrow samples. Results Flow cytometry showed that in normal bone marrow, there was no Mer expressed on granulocytes, T-lymphocytes and B-lymphocytes; and middle-expression on monocytes(37.5%). In all 32 AML patients, there were 23 Mer positive(71.8%), Mer expression level was high in 3 AML patients, middle in 8 AML patients, low in 12 AML patients and very low/negative in left 9 AML patients. Among 3 Mer high Expression AML patients, the FAB typping were all M1, and all of them had the high expression level of CD34 and CD117. In all 25 ALL patients, there were 16 Mer positive(64.0%), Mer expression level was high in 1 ALL patients, middle in 6 ALL patients, low in 9 ALL patients and very low/negative in left 9 ALL patients. The results of RT-PCR was similar to flow cytometry Conclusion Mer was ectopic expression parts of adults acute leukemia patients, and may related to genesis and development of acute leukemia.

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