HPV-Negative Vulvar Squamous Cell Carcinoma in a 21-year-old Patient

Vulvar Squamous Cell Carcinoma usually occurs among women in their 60s or 70s. There are a limited number of reports of vulvar cancer cases younger than 30 years. These patients have usually risk factors such as human papillomavirus (HPV) infection. In this report, the authors present a rare case of invasive vulvar squamous cell carcinoma in a 21-year-old patient without HPV infection. Surgical treatment was performed, followed by adjuvant radiation therapy.

Do Intermediate Risk Factors Alone Pose Sufficient Risk to Justify Adjuvant Radiation Therapy (RT) in Pathologic Node-Negative (pN0) Oral Cavity (OC) Squamous Cell Carcinoma (SCC)?

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2016.06.1575 ◽

2016 ◽

Vol 96 (2) ◽

pp. E375-E376

Author(s):

J.R. Parkhurst ◽

S.L. Mott ◽

C.M. Anderson ◽

N. Pagedar ◽

R. Bayon ◽

...

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Radiation Therapy ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Adjuvant Radiation ◽

Intermediate Risk ◽

Node Negative ◽

Adjuvant Radiation Therapy for Vulvar Squamous Cell Carcinoma: Does p16-Positivity Influence Locoregional Control?

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2018.07.1782 ◽

2018 ◽

Vol 102 (3) ◽

pp. e657-e658

Author(s):

M. Dohopolski ◽

Z.D. Horne ◽

D. Pradhan ◽

R. Bhargava ◽

R.P. Edwards ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Radiation Therapy ◽

Cell Carcinoma ◽

Squamous Cell ◽

Locoregional Control ◽

Adjuvant Radiation ◽

Comprehensive analysis of HPV infection, EGFR exon 20 mutations and LINE1 hypomethylation as risk factors for malignant transformation of sinonasal-inverted papilloma to squamous cell carcinoma

International Journal of Cancer ◽

10.1002/ijc.31971 ◽

2018 ◽

Vol 144 (6) ◽

pp. 1313-1320 ◽

Cited By ~ 24

Author(s):

Nora Sahnane ◽

Giorgia Ottini ◽

Mario Turri-Zanoni ◽

Daniela Furlan ◽

Paolo Battaglia ◽

...

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Malignant Transformation ◽

Squamous Cell ◽

Hpv Infection ◽

Comprehensive Analysis ◽

Inverted Papilloma ◽

Sinonasal Inverted Papilloma ◽

Exon 20

Risk factors for the development of lymph node metastasis in vulvar squamous cell carcinoma

International Journal of Gynecology & Obstetrics ◽

10.1016/0020-7292(91)90264-6 ◽

1991 ◽

Vol 34 (2) ◽

pp. 194-194

Author(s):

SW Binder ◽

I Huang ◽

YS Fu ◽

NF Hacker ◽

JS Berek

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Cell Carcinoma ◽

Squamous Cell ◽

Node Metastasis

Role of adjuvant radiation or re-excision for early stage vulvar squamous cell carcinoma with positive or close surgical margins

Gynecologic Oncology ◽

10.1016/j.ygyno.2019.05.028 ◽

2019 ◽

Vol 154 (2) ◽

pp. 276-279 ◽

Cited By ~ 3

Author(s):

Sabrina M. Bedell ◽

Chloe Hedberg ◽

Anna Griffin ◽

Hannah Pearson ◽

Annelise Wilhite ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Early Stage ◽

Surgical Margins ◽

Adjuvant Radiation ◽

Vulvar Squamous Cell Carcinoma

The Impact of Extra-Nodal Extension on Survival in Patients with HPV+ Oropharyngeal Squamous Cell Carcinoma Treated with Adjuvant Radiation Therapy

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2018.07.720 ◽

2018 ◽

Vol 102 (3) ◽

pp. e203

Author(s):

S. Baliga ◽

R. Kabarriti ◽

C. Guha ◽

S. Kalnicki ◽

M.K. Garg

Keyword(s):

Squamous Cell Carcinoma ◽

Radiation Therapy ◽

Cell Carcinoma ◽

Squamous Cell ◽

Oropharyngeal Squamous Cell Carcinoma ◽

Adjuvant Radiation ◽

Adjuvant Radiation Therapy ◽

The Impact

The Incidence and Patterns of Failure in Patients With Stage I/II Squamous Cell Carcinoma of the Oral Cavity (SCC-OC) Treated With Surgery Alone: Implications for Adjuvant Radiation Therapy

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2013.06.1138 ◽

2013 ◽

Vol 87 (2) ◽

pp. S432

Author(s):

J. Han ◽

A.R. Noble ◽

C.A. Reddy ◽

J. Scharpf ◽

E. Lamarre ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Radiation Therapy ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Stage I ◽

Adjuvant Radiation ◽

Patterns Of Failure ◽

Role of Concurrent Systemic Therapy with Adjuvant Radiation Therapy for Locally Advanced Cutaneous Head and Neck Squamous Cell Carcinoma

Cureus ◽

10.7759/cureus.1784 ◽

2017 ◽

Author(s):

Uma Goyal ◽

Nitin K Prabhakar ◽

Rajayogesh Davuluri ◽

Christopher M Morrison ◽

Sun K Yi

Keyword(s):

Squamous Cell Carcinoma ◽

Radiation Therapy ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Systemic Therapy ◽

Locally Advanced ◽

Adjuvant Radiation ◽

The impact of HPV infection on risk of progression and overall mortality in vulvar squamous cell carcinoma: a retrospective single-center analysis

10.31487/j.jso.2019.01.003 ◽

2019 ◽

Author(s):

Anna Daniela Iacobone

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Hpv Infection ◽

Single Center ◽

Risk Of Progression ◽

The Impact ◽

Overall Mortality

A Case of Stage I Vulvar Squamous Cell Carcinoma with Early Relapse and Rapid Disease Progression

Case Reports in Oncological Medicine ◽

10.1155/2019/1018492 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4

Author(s):

Marta Peri ◽

Antonino Grassadonia ◽

Laura Iezzi ◽

Patrizia Vici ◽

Michele De Tursi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Early Diagnosis ◽

Cell Carcinoma ◽

Squamous Cell ◽

Vulvar Cancer ◽

Early Stage ◽

Rapid Disease Progression ◽

Early Relapse ◽

Dismal Prognosis

Squamous cell carcinoma (SCC) is the most common subtype of vulvar cancer. Locoregional surgery is often curative when the tumor is diagnosed at an early stage. However, the disease can unexpectedly evolve with a dismal prognosis even after an early diagnosis. We report a case of a woman who experienced a rapid, chemorefractory tumor progression after surgery for stage IB vulvar SCC.