An Uncommon Presentation of Gastric Metastasis of a Breast Cystosarcoma Phyllodes Tumor

Abstract Background Fibroadenoma is the most prevalent benign breast lesion that generally affects middle-aged women; it is rare in adolescents and younger children. The transformation into malignancy is not common. However, multiple recurrences of rapidly enlarging fibroadenomas suggest a high possibility of transforming into phyllodes tumors, which are uncommon fibroepithelial lesions that account for 0.3–0.5% of female breast tumors and typically present in premenopausal women. Case presentation We report a case of a 17-year-old Syrian girl who previously had three episodes of recurrence of multiple rapidly enlarging fibroadenomas in her left breast and underwent three operations for complete resection of the lesions. However, a few months later, she was readmitted with multiple large masses in the same breast, and pathological findings confirmed a surprising combination of multiple fibroadenomas for the fourth time with a malignant phyllodes tumor (cystosarcoma phyllodes). The patient underwent lumpectomies followed by adjuvant radiotherapy. Long-term follow-up was recommended. Conclusion Our patient had an extraordinary number of episodes of recurrence at a young age and a rare combination of malignant and benign lesions in the same breast with multiple recurrences. We present her unique, very challenging case with the aim of highlighting the importance of clinical correlation, detailed diagnosis, and careful follow-up.

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Cystosarcoma Phyllodes Metastatic to the Mandible: Report of a Rare Case and Literature Review

Ear Nose & Throat Journal ◽

10.1177/014556130308200513 ◽

2003 ◽

Vol 82 (5) ◽

pp. 380-381 ◽

Cited By ~ 2

Author(s):

Jonathan B. Staton ◽

Thomas H. Costello ◽

F. Daniel Donovan ◽

Robert E. Laster

Keyword(s):

Literature Review ◽

Breast Neoplasm ◽

Breast Tumor ◽

Rare Case ◽

Phyllodes Tumor ◽

Malignant Potential ◽

Cystosarcoma Phyllodes ◽

The Third

Cystosarcoma phyllodes is a rare breast tumor with variable malignant potential. Metastasis has been reported in a small percentage of cases. We describe the case of a 52-year-old woman who developed a large facial tumor 1 year after she had undergone a mastectomy fora rapidly enlarging breast neoplasm. The facial lesion was found to be a malignant cystosarcoma phyllodes metastatic to the mandible, and the patient died shortly after diagnosis. To our knowledge, this patient represents only the third reported case of a phyllodes tumor metastatic to the mandible.

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Recurrent malignant phyllodes tumor of breast with gastric metastasis

Journal of Cancer Research and Practice ◽

10.4103/jcrp.jcrp_21_18 ◽

2019 ◽

Vol 6 (3) ◽

pp. 132

Author(s):

Hsin-Chen Lin ◽

Cheng-Wei Chou

Keyword(s):

Phyllodes Tumor ◽

Gastric Metastasis ◽

Malignant Phyllodes Tumor

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Cystosarcoma phyllodes (phyllodes tumor) of the male breast

Surgery ◽

10.1067/msy.2003.145 ◽

2003 ◽

Vol 133 (6) ◽

pp. 689-691 ◽

Cited By ~ 8

Author(s):

Erica L. Campagnaro ◽

Kenneth J. Woodside ◽

Shu-Yuan Xiao ◽

John A. Daller ◽

B.Mark Evers

Keyword(s):

Phyllodes Tumor ◽

Male Breast ◽

Cystosarcoma Phyllodes

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A clinical review of 33 cases of breast phyllodes tumor over the last 20 years

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.10629 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 10629-10629

Author(s):

M. S. Lenhard ◽

S. Kahlert ◽

I. Himsl ◽

N. Ditsch ◽

M. Untch ◽

...

Keyword(s):

Lymph Node ◽

Local Recurrence ◽

Tumor Size ◽

Phyllodes Tumor ◽

Distant Metastases ◽

Primary Diagnosis ◽

Axillary Lymph ◽

Malignant Phyllodes Tumor ◽

Cystosarcoma Phyllodes

10629 Background: The “Cystosarcoma phyllodes” of the breast is a rare entity which accounts for 0.5 % of all breast neoplasms. The diagnosis should be considered in all rapidly growing breast nodules. We reviewed all cases of this rare disease that presented at our hospital in the last 20 years. Methods: The data of 5270 patients with primary breast neoplasms treated in our department between 1984 and 2005 were retrospectively analyzed for the histopathologic diagnosis of a cystosarcoma phyllodes. Results: 33 patients with cystosarcoma phyllodes of the breast could be identified. The median age at diagnosis was 47 years. Median follow up was 86 months. The tumors were classified histologically into benign (40%), borderline (27%) and malignant tumors (33%) based on standardized criteria; 3 tumors were unclassified. Surgery was conducted as a breast conserving (58%) or radical operation (mastectomy) (42%). Median tumor size was 7.1 cm, and no lymph node infiltration was found in the 8 patients who received axillary lymph node dissection. Local recurrence occured in 8 patients (26%). 75% (6/8) of the patients with a local recurrence had been treated with a breast conserving surgery. In patients with the diagnosis of a malignant phyllodes tumor we observed a recurrence rate of 40% (4/10), in those with borderline tumors of 25% (2/8) whereas those with benign phylloides tumor had a local relapse rate of 8% (1/12). Distant metastases were seen in 4 patients (12%) with a malignant phyllodes tumor. All patients with distant metastases in the follow up had been treated radically at primary diagnosis. Neither regarding age at primary diagnosis nor in tumor size there was a significant difference between patients with local recurrence or metastasic spread and those without (p = 0.284 tumor size, p = 0.739 for age, Wilcoxon-W). Conclusions: We recommend local excision with appropiate surgical margins in all patients if the tumor-to-breast ratio is sufficient for good cosmesis. Based on our data, routine axillary lymph node dissection is not recommended. Patients with a malignant tumor are at higher risk for local recurrence and metastasic spread. Therefore, the histopathologic classification seems to be the strongest prognostic factor in this disease. No significant financial relationships to disclose.

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Astonishingly rapid growth of malignant cystosarcoma phyllodes tumor in a pregnant womana case report

International Journal of Gynecological Cancer ◽

10.1111/j.1525-1438.2007.01077.x ◽

2008 ◽

Vol 18 (4) ◽

pp. 856-859 ◽

Cited By ~ 4

Author(s):

D NEJC ◽

G. PASZ-WALCZAK ◽

J. PIEKARSKI ◽

P. PLUTA ◽

A. BILSKI ◽

...

Keyword(s):

Case Report ◽

Rapid Growth ◽

Phyllodes Tumor ◽

Cystosarcoma Phyllodes

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Bone metastasis from malignant phyllodes of the breast

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20194590 ◽

2019 ◽

Vol 7 (11) ◽

pp. 4364

Author(s):

Daniel Oktavianus Dau ◽

I. Wayan Sudarsa

Keyword(s):

Case Report ◽

Bone Metastasis ◽

Breast Tumor ◽

Benign Tumor ◽

Phyllodes Tumor ◽

Breast Tumors ◽

Upper Arm ◽

Malignant Phyllodes Tumor ◽

Cystosarcoma Phyllodes ◽

The Right

Cystosarcoma phyllodes was described first in 1838 and originally was considered to be a benign tumor. It was not until 1931 that metastasis from a cystosarcoma phyllodes was reported. The incidence of cystosarcoma phyllodes is estimated to be 0.3% to 0.9% of all breast tumors. Sites most commonly affected by metastases are the lungs and bones. We present a case report 29-year old female patient presented with a voluminous breast mass at both of them which was completely resected. The right side presented of malignant phyllodes and the left side is borderline phyllodes. Six months later, both of her legs became paralyzed and accompanied by swelling over her right upper arm. Biopsy was performed, and the diagnosis was metastatic malignant phyllodes tumor. Histologic review of the breast tumor revealed stromal overgrowth.

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