scholarly journals Assessment of the risk to human health through the pesticide active substance dimethoate and its metabolites in food

EFSA Journal ◽  
2016 ◽  
Vol 14 (4) ◽  
Author(s):  
Keyword(s):  
Human Health ◽  
Active Substance

Comparative Phytotoxicity Assays of the Herbicide Alloxydim and Its Main Identified Photoproduct in Cereal and Broadleaves Crops

Weed Science ◽  
2015 ◽  
Vol 63 (2) ◽  
pp. 377-387 ◽  
Author(s):  
Pilar Sandín-España ◽  
Beatriz Sevilla-Morán ◽  
Mercedes Villarroya-Ferruz ◽  
José L. Alonso-Prados ◽  
M. Inés Santín-Montanyá
Keyword(s):  
Human Health ◽  
Active Substance ◽  
Degradation Products ◽  
Model Systems ◽  
Parent Substance ◽  
Cereal Crops ◽  
Rapid Degradation ◽  
Soil Model ◽  
Plant Cuticles ◽  
Grass Weed

When herbicides are sprayed in the field, a proportion of the herbicide falls onto leaves and soil surfaces, where it can be exposed to sunlight, generating photoproducts that can be more toxic and/or persistent than the parent substance and affect human health and the environment. The aim of this study was to identify the photoproducts of the herbicide alloxydim in leaf and soil model systems and to perform phytotoxicity studies. Alloxydim was rapidly photodegraded in systems simulating plant cuticles and soil surfaces, with half-lives ranging from 1 to 30 min. The main by-product, identified by LC-Qtof-MS as deallyoxylated alloxydim, was more stable than the active substance. The EC50values on root lengths of different varieties of wheat plants and one grass weed ranged from 0.38 to 0.50 mg L−1for alloxydim. In contrast, the EC50values for deallyoxylated alloxydim ranged from 94 to 600 mg L−1in the same species and in crops where the herbicide was applied. Special attention should be given to alloxydim degradation products because of the rapid degradation of this herbicide. Comparative bioassay studies between alloxydim and its photostable by-product showed that the by-product presents low phytotoxicity, whereas alloxydim can cause injury to neighboring and succeeding cereal crops.

scholarly journals MASI: microbiota—active substance interactions database

2020 ◽  
Vol 49 (D1) ◽  
pp. D776-D782
Author(s):  
Xian Zeng ◽  
Xue Yang ◽  
Jiajun Fan ◽  
Ying Tan ◽  
Lingyi Ju ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Human Health ◽  
Active Substance ◽  
Gut Bacteria ◽  
Healthy Individuals ◽  
Insufficient Information ◽  
Disease Associations ◽  
Regulated Functions ◽  
Drug Interventions ◽  
Active Substances

Abstract Xenobiotic and host active substances interact with gut microbiota to influence human health and therapeutics. Dietary, pharmaceutical, herbal and environmental substances are modified by microbiota with altered bioavailabilities, bioactivities and toxic effects. Xenobiotics also affect microbiota with health implications. Knowledge of these microbiota and active substance interactions is important for understanding microbiota-regulated functions and therapeutics. Established microbiota databases provide useful information about the microbiota-disease associations, diet and drug interventions, and microbiota modulation of drugs. However, there is insufficient information on the active substances modified by microbiota and the abundance of gut bacteria in humans. Only ∼7% drugs are covered by the established databases. To complement these databases, we developed MASI, Microbiota—Active Substance Interactions database, for providing the information about the microbiota alteration of various substances, substance alteration of microbiota, and the abundance of gut bacteria in humans. These include 1,051 pharmaceutical, 103 dietary, 119 herbal, 46 probiotic, 142 environmental substances interacting with 806 microbiota species linked to 56 diseases and 784 microbiota–disease associations. MASI covers 11 215 bacteria-pharmaceutical, 914 bacteria-herbal, 309 bacteria-dietary, 753 bacteria-environmental substance interactions and the abundance profiles of 259 bacteria species in 3465 patients and 5334 healthy individuals. MASI is freely accessible at http://www.aiddlab.com/MASI.

Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp (Ctenopharyngodon idellus) via suppression of oxidative stress, inflammation and apoptosis

2020 ◽  
Vol 11 (10) ◽  
pp. 8547-8559
Author(s):  
Hongjing Zhao ◽  
Yu Wang ◽  
Mengyao Mu ◽  
Menghao Guo ◽  
Hongxian Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Secondary Metabolites ◽  
Human Health ◽  
Grass Carp ◽  
Aquatic Environment ◽  
Ctenopharyngodon Idellus

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health.

Emerging Nutrition Gaps in a World of Affluence - Micronutrient Intake and Status Globally

2011 ◽  
Vol 81 (4) ◽  
pp. 238-239 ◽  
Author(s):  
Manfred Eggersdorfer ◽  
Paul Walter
Keyword(s):  
Developing Countries ◽  
Human Health ◽  
Old Age ◽  
Molecular Basis ◽  
Health Benefit ◽  
Developed Countries ◽  
Micronutrient Deficiencies ◽  
New Science ◽  
Health And Nutrition ◽  
Micronutrient Intake

Nutrition is important for human health in all stages of life - from conception to old age. Today we know much more about the molecular basis of nutrition. Most importantly, we have learnt that micronutrients, among other factors, interact with genes, and new science is increasingly providing more tools to clarify this interrelation between health and nutrition. Sufficient intake of vitamins is essential to achieve maximum health benefit. It is well established that in developing countries, millions of people still suffer from micronutrient deficiencies. However, it is far less recognized that we face micronutrient insufficiencies also in developed countries.

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