Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp (Ctenopharyngodon idellus) via suppression of oxidative stress, inflammation and apoptosis

Hongjing Zhao; Yu Wang; Mengyao Mu; Menghao Guo; Hongxian Yu; Mingwei Xing

doi:10.1039/d0fo01638a

Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp (Ctenopharyngodon idellus) via suppression of oxidative stress, inflammation and apoptosis

Food & Function ◽

10.1039/d0fo01638a ◽

2020 ◽

Vol 11 (10) ◽

pp. 8547-8559

Author(s):

Hongjing Zhao ◽

Yu Wang ◽

Mengyao Mu ◽

Menghao Guo ◽

Hongxian Yu ◽

...

Keyword(s):

Oxidative Stress ◽

Secondary Metabolites ◽

Human Health ◽

Grass Carp ◽

Aquatic Environment ◽

Ctenopharyngodon Idellus

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health.

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Effects of l-carnitine against H2O2-induced oxidative stress in grass carp ovary cells (Ctenopharyngodon idellus)

Fish Physiology and Biochemistry ◽

10.1007/s10695-015-0179-x ◽

2015 ◽

Vol 42 (3) ◽

pp. 845-857 ◽

Cited By ~ 12

Author(s):

Qiuju Wang ◽

Xue Ju ◽

Yuke Chen ◽

Xiaoqing Dong ◽

Sha Luo ◽

...

Keyword(s):

Oxidative Stress ◽

Grass Carp ◽

Ctenopharyngodon Idellus ◽

Ovary Cells

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Oxidative Stress Is Involved In The Activation of NF-κB Signal Pathway And Immune Inflammatory Response In Grass Carp Gill Induced By Cypermethrin And/Or Sulfamethoxazole Exposure

10.21203/rs.3.rs-634863/v1 ◽

2021 ◽

Author(s):

Baoying Li ◽

Yu Wang ◽

Hongjing Zhao ◽

Kai Yin ◽

Yachen Liu ◽

...

Keyword(s):

Oxidative Stress ◽

Grass Carp ◽

Aquatic Environment ◽

Environmental Pollutants ◽

Nuclear Factor Κb ◽

Signal Pathway ◽

Toxic Effects ◽

Stress Index ◽

Separate Analysis ◽

Fish Gills

Abstract At present, the concentration of environmental pollutants, such as pesticides and antibiotics exposed in environment, especially in aquatic environment is increasing. These contaminants are exposed through aquatic environment to fish and ultimately accumulate in humans. Research on environmental pollutants has exploded in the past two years. However, there are still few studies on the combined effects of pesticides and antibiotics on fish, especially on fish gills. A separate analysis of the toxic effects caused by an environmental pollutant cannot fully show the real situation. In this paper, cypermethrin (CMN) and sulfamethoxazole (SMZ) were analyzed and found that there was a strong correlation between the pathways affected by the first 30 genes regulated by CMN and SMZ respectively. Therefore, the toxic effects of CMN (0.651 μg/L) and/or SMZ (0.3 μg/L) on grass carp gill were studied in this paper. Histopathology, quantitative real-time PCR and other methods were used to detect the tissue morphology, oxidative stress level, inflammation and apoptosis-related indicators of the fish gills after exposure 42 days. It was found that compared with the single exposure (SMZ/CMN) group, the combined exposure (MIX) group had a more pronounced oxidative stress index imbalance. At the same time, nuclear factor-κB (NF-κB) signal pathway was activated and immuno-inflammatory reaction appeared in MIX group. This study reveals the harm of CMN and SMZ to fish, and provides a reference and basis for the rational use of pesticides and antibiotics.

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