Pengaruh Rasio HA/TCP terhadap Karakteristik Komposit BCP-Gelatin-CMC sebagai Bahan Injectable Bone Substitute

Mochammad Dachyar Effendi; Nandang Suhendra

doi:10.29122/jitm.v1i2.3837

Pengaruh Rasio HA/TCP terhadap Karakteristik Komposit BCP-Gelatin-CMC sebagai Bahan Injectable Bone Substitute

Jurnal Inovasi dan Teknologi Material ◽

10.29122/jitm.v1i2.3837 ◽

2020 ◽

Vol 1 (2) ◽

pp. 15-20

Author(s):

Mochammad Dachyar Effendi ◽

Nandang Suhendra

Keyword(s):

Calcium Phosphate ◽

Bone Substitute

Penambahan bahan semen tulang kedalam rongga tulang dapat menjadi salah satu alternatif untuk mencegah kerusakan tulang akibat osteoporosis. Kelemahan utama dari bahan implant ortopedik berbasis hydroksiapatit sinter adalah bahan dalam bentuk solid dimana dalam aplikasi pembedahan, sulit untuk mengisi rongga tulang dengan ukuran tertentu. Alternatif yang nyaman untuk bahan pengisi tulang suspensi adalah denganÂ menggunakan bahan Injectable bone substitute. Dalam studi ini dipelajari komposisi material Injectable Bone substitute dengan matrik berupa polimer CMC-gelatin dan HA/TCP sebagai filler. Dilakukan variasi rasio Hidroksiapatit (HA) / tri-calcium phosphate (TCP) (70:30; 50:50; 40:60) Â untuk Â mempelajari pengaruhnya terhadap sifat-sifat fisik dan mekanik campuran. Hasil uji FTIR menunjukkan gugus fungsi fosfat (PO43-) gugus fungsi karboksil dan gugus fungsi NH2 yang merujuk kepadaÂ bahan penyusunnya. Peningkatan porositas karena perubahan morfologi dikonfirmasi oleh gambar mikroskop polaritas. Hasil uji tekan menunjukkan berkurangnya Â nilai kuat tekan dengan bertambahnya konsentrasi TCP dalam campuran. Semua kelompok uji menunjukkan kemiripan struktural dengan tulang cancellous dalam sifat porositas dan kekuatan mekanik.

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Biphasic calcium phosphate as a bone substitute

Frontiers in Bioengineering and Biotechnology ◽

10.3389/conf.fbioe.2016.01.00487 ◽

2016 ◽

Vol 4 ◽

Author(s):

Pluta Klaudia ◽

Walczyk Dorota ◽

Sobczak-Kupiec Agnieszka ◽

Malina Dagmara ◽

Tyliszczak Bozena

Keyword(s):

Calcium Phosphate ◽

Bone Substitute ◽

Biphasic Calcium Phosphate

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Octacalcium phosphate bone substitute materials: Comparison between properties of biomaterials and other calcium phosphate materials

Dental Materials Journal ◽

10.4012/dmj.2020-001 ◽

2020 ◽

Vol 39 (2) ◽

pp. 187-199 ◽

Cited By ~ 3

Author(s):

Osamu SUZUKI ◽

Yukari SHIWAKU ◽

Ryo HAMAI

Keyword(s):

Calcium Phosphate ◽

Bone Substitute ◽

Octacalcium Phosphate ◽

Bone Substitute Materials ◽

Substitute Materials

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From Bio-waste to Bone Substitute

Chemical and Biochemical Engineering Quarterly ◽

10.15255/cabeq.2020.1783 ◽

2020 ◽

Vol 34 (2) ◽

pp. 59-71

Author(s):

Antonia Ressler ◽

Karla Zadro ◽

Hrvoje Ivanković ◽

Marica Ivanković ◽

Matija Cvetnić ◽

...

Keyword(s):

Calcium Phosphate ◽

Bone Substitute ◽

Bone Growth ◽

Composite Scaffold ◽

Composite Scaffolds ◽

Nanocomposite Structure ◽

Na Ions ◽

Biomimetic Hydroxyapatite ◽

Highly Porous ◽

Interconnected Pores

Nanocomposite structure of the bone can be mimicked by chitosan/hydroxyapatite (CS/HAp) composite scaffold. Biological hydroxyapatite (HAp) contains various ions, which have a crucial role in bone growth. The aim of the present work was to synthesize biomimetic hydroxyapatite and prepare composite scaffolds based on chitosan, where HAp was synthesised from hen eggshells, seashells and cuttlefish bone. The powders were composed of nano-structured calcium deficient HAp and amorphous calcium phosphate (ACP). In the as-prepared powders, Sr2+, Mg2+ and Na+ ions were detected as a result of using biogenic precursor of Ca2+ ions. Highly porous CS/HAp structures have been prepared by freeze-gelation technique. The CS/HAp scaffolds have shown highly porous structure with very well interconnected pores and homogeneously dispersed HAp particles. The MTT assay of CS/HAp scaffolds has shown no toxicity, and the live/dead assay has confirmed good viability and proliferation of seeded cells.

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3D printing of bone substitute implants using calcium phosphate and bioactive glasses

Journal of the European Ceramic Society ◽

10.1016/j.jeurceramsoc.2010.04.037 ◽

2010 ◽

Vol 30 (12) ◽

pp. 2563-2567 ◽

Cited By ~ 198

Author(s):

Christian Bergmann ◽

Markus Lindner ◽

Wen Zhang ◽

Karolina Koczur ◽

Armin Kirsten ◽

...

Keyword(s):

Calcium Phosphate ◽

3D Printing ◽

Bone Substitute ◽

Bioactive Glasses

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Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.361-363.119 ◽

2007 ◽

Vol 361-363 ◽

pp. 119-122 ◽

Cited By ~ 4

Author(s):

J.H. Lim ◽

J.H. Park ◽

Eui Kyun Park ◽

Hae Jung Kim ◽

Il Kyu Park ◽

...

Keyword(s):

Tissue Engineering ◽

Calcium Phosphate ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Bone Substitute ◽

Biphasic Calcium Phosphate ◽

Bone Defects ◽

Calcium Phosphate Ceramic ◽

Ceramic Scaffold ◽

Porous Biphasic Calcium Phosphate

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.

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Bone Regenerative Properties of Injectable Calcium Phosphate/PLGA Cement in an Alveolar Bone Defect

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.529-530.300 ◽

2012 ◽

Vol 529-530 ◽

pp. 300-303 ◽

Cited By ~ 1

Author(s):

R.P. Félix Lanao ◽

J.W.M. Hoekstra ◽

Joop G.C. Wolke ◽

Sander C.G. Leeuwenburgh ◽

A.S. Plachokova ◽

...

Keyword(s):

Growth Factors ◽

Growth Factor ◽

Calcium Phosphate ◽

Bone Formation ◽

Bone Substitute ◽

Alveolar Bone ◽

Bone Defects ◽

Plga Microspheres ◽

Bone Substitute Material ◽

Substitute Material

Periodontitis is one of the most common inflammatory diseases, which can lead to early tooth loss. The conventional treatment of periodontitis is to arrest the disease progression. Most reconstructive procedures involve application of bone substitutes, barrier membranes or a combination of both into the bony defects. Calcium phosphate cements (CPCs) are the predominant type of bone substitute material used for reasons of injectability and hence perfect filling potential for bone defects. Recently, injectable apatitic CPCs demonstrated to be more rapidly degradable when combined with poly (lactic-co-glycolic) acid (PLGA) microspheres. Further, PLGA microspheres can be used as a delivery vehicle for growth factors. In this study, the performance of injectable CPCs as a bone substitute material for alveolar bone defects created in Beagle dogs was evaluated. Four CPC-formulations were generated by incorporating hollow or dense PLGA microspheres, either or not loaded with the growth factors (platelet derived growth factor (PDGF) and insulin-like growth factor (IGF). Implantation period was 8 weeks. Bone formation was based on histological and histomorphometrical evaluation. The results demonstrated that filling alveolar bone defects with CPC-dense PLGA revealed significant more bone formation compared to CPC-hollow PLGA either or not loaded with IGF and PDGF. In summary, we conclude that injectable CPC-dense PLGA composites proved to be the most suitable material for a potential use as off the shelf material due to its good biocompatibility, enhanced degradability and subsequent bone formation.

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