scholarly journals Options for antibacterial prophylaxis of infectious complications of prostate biopsy

2021 ◽  
Vol 14 (3) ◽  
pp. 150-155
Author(s):  
S.V. Popov ◽  
◽  
I.N. Orlov ◽  
D.Yu. Chernysheva ◽  
T.M. Topuzov ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Clinical Guidelines ◽  
Urine Culture ◽  
Infectious Complications ◽  
Antibacterial Prophylaxis ◽  
Scientific Databases ◽  
Transrectal Prostate Biopsy ◽  
Long Time ◽  
Transperineal Biopsy

Introduction. Amount of prostate biopsy procedures rises every year and up to 95% of cases of prostate biopsy is performed via transrectal approach. The incidence of infectious complications of transrectal prostate biopsy reaches up to 17%, while incidence of such complications of transperineal biopsy is about 1%. The majority of international clinical guidelines recommends for obligatory antibiotic prophylaxis prior to prostate biopsy of any approach, but the choice of antibiotic is still debatable. The aim of this review is to sum up the approaches of international urological guidelines to the antibiotic prophylaxis prior to prostate biopsy. Materials and methods. We analyzed the search results in the scientific databases PubMed, Google Scolar, elibrary.ru for the queries «prostate biopsy», «antibacterial prophylaxis» and «guidelines». Results. According to the recommendations of most professional communities, antibacterial prophylaxis of infectious complications of prostate biopsy can be carried out in various ways - once or for a long time, one- or two-component, empirically or on the basis of urine culture on microflora. Conclusion. Despite the differences in the levels of sensitivity and resistance of coliform flora around the world, the clinical guidelines in most countries are uniform in terms of the choice of drugs to reduce the risk of developing infectious complications after prostate biopsy. Approaches to antibacterial prophylaxis after prostate biopsy differ only depending on the type of biopsy access.

scholarly journals Combined antibiotic prophylaxis of infectious complications of prostate biopsy

2021 ◽  
Vol 22 (3) ◽  
pp. 49-55
Author(s):  
N. A. Grigoryev ◽  
I. I. Abdullin ◽  
B. R. Gvasalia ◽  
A. V. Loginov ◽  
E. V. Zhilyaev
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Antimicrobial Prophylaxis ◽  
Average Length ◽  
Infectious Complications ◽  
Fluoroquinolone Resistance ◽  
Single Shot ◽  
Average Length Of Stay ◽  
Transrectal Prostate Biopsy ◽  
Fosfomycin Trometamol

Introduction. Biopsy of prostate is a routine urologic procedure. Nevertheless the frequency of infectious-inflammatory complications remain high, despite the recommended antibiotic prophylaxis schemes.Purpose. The evaluation of effectiveness and safety of combined antimicrobial prophylaxis: fosfomycin trometamol and fluoroquinolones of 3rd generation.Materials and methods. Our clinical study included 80 patients who underwent prostate biopsy were divided into 2 groups. The first group of 40 patients received routine prophylaxis: levofloxacin 500 mg 6 h before the biopsy and 500 mg per day during 4 days after biopsy. The second group of 40 patients, along with standard prophylaxis as in the first group, additionally after biopsy received fosfomycin trometamol 3 gr single-shot.Results. In the first group, infectious and inflammatory complications occurred in 8 (20 %) patients, 12.5 % of patients from the first group were hospitalized for parenteral antibiotic therapy. The average length of stay in hospital was 3.4 ± 1.45 days. In all cases, in the first group of patients, Escherichia coli was detected, in 70 % of cases fluoroquinolone-resistant strain of the bacterium was received. In the second group of patients no hospitalization was required. One (2.5 %) patient out of forty from this group showed signs of urinary tract infection, which was not accompanied by an increase of body temperature, as well as changes in blood and urine tests.Conclusions. Our results show good effectiveness and safety of combined antibiotic prophylaxis for transrectal prostate biopsy. Since fluoroquinolone resistance grows, it is necessary to introduce alternative schemes, as well as monitoring of nosocomial infection and controlling of antimicrobial therapy.

scholarly journals The first experience of transperineal prostate biopsy without antibiotic prophylaxis

2021 ◽  
Vol 17 (2) ◽  
pp. 46-52
Author(s):  
D. Yu. Chernysheva ◽  
S. V. Popov ◽  
I. N. Orlov ◽  
A. V. Tsoy ◽  
V. A. Neradovskiy
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Soft Tissues ◽  
Urine Culture ◽  
Randomized Study ◽  
Control Group ◽  
Antibacterial Prophylaxis ◽  
Safe Alternative ◽  
Transperineal Prostate Biopsy ◽  
Complications Rate

Objective: to study the safety of omitting the antibiotic prophylaxis before transperineal prostate biopsy.Materials and methods. The prospective randomized study included data, obtained during the diagnostical process of 85 patients, who underwent transperineal prostate biopsy in 2020. In the control group (n = 50) patients received 1 g Ceftriaxone IV 1 h before the biopsy. In the study group (n = 35) biopsy was performed without previous antibacterial prophylaxis. Age median was 63.2 (52-75) years.Results. No significant differences in the infection complications rate (UTI, soft tissues infections, prostatitis, fever, sepsis) were obtained between the groups. No patient developed UTI, prostatitis or sepsis, confirmed with urine culture.Conclusion. Performing transperineal prostate biopsy without antibiotic prophylaxis seems to be a safe alternative to common prophylaxis regiments, dedicated to infection complications prevention after prostate biopsy.

Rectal culture-directed antibiotic prophylaxis before transrectal prostate biopsy: Reduced infectious complications and healthcare costs

2018 ◽  
Vol 42 (7) ◽  
pp. 465-472
Author(s):  
J.V. Baldissera-Aradas ◽  
L. Rodríguez-Villamil ◽  
R. Blanco-Fernández ◽  
C. Pérez-García ◽  
G. Viejo de la Guerra ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Healthcare Costs ◽  
Infectious Complications ◽  
Transrectal Prostate Biopsy

scholarly journals Prevalence, Risk Factors, and Clinical Relevance of Fluoroquinolone-Resistant Organisms in Rectal Cultures: Should We Target Antibiotic Prophylaxis Prior to Prostate Biopsy?

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
J. Van Besien ◽  
P. Uvin ◽  
A. M. Van den Abeele ◽  
L. Merckx
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Infectious Complications ◽  
Fluoroquinolone Resistance ◽  
Resistant Bacteria ◽  
Confounding Variables ◽  
Transrectal Prostate Biopsy ◽  
Patients At Risk ◽  
Resistance Rates ◽  
Targeted Approach

The rise of infectious complications after prostate biopsy has been linked to the growing resistance of enterobacteria to fluoroquinolone (FQ) antibiotics. In this review, we investigated the potential benefit of targeted antibiotic prophylaxis based on rectal cultures prior to prostate biopsy. An electronic search for all related literature published in English was performed from April until June 2015 using the MEDLINE and EMBASE databases. Data were obtained regarding the true prevalence of FQ-resistant bacteria in the rectum of patients, the identification of those patients at risk of harbouring FQ-resistant bacteria, the risk of infectious complications after transrectal prostate biopsy in patients with FQ-resistant bacteria, and the effect of targeted prophylaxis. Although there is limited evidence that a targeted approach might be beneficial, we conclude that current studies on the use of rectal cultures in the prebiopsy setting have too many limitations and confounding variables to definitely accept this approach in clinical practice. Whether this methodology is useful in a certain region will greatly depend on local fluoroquinolone-resistance rates.

scholarly journals Impact of Rectal Swabs on Infectious Complications after Transrectal Prostate Biopsy

2016 ◽  
Vol 97 (3) ◽  
pp. 340-346 ◽  
Author(s):  
Carlos Gustavo Trujillo ◽  
Mauricio Plata ◽  
Juan Ignacio Caicedo ◽  
Juan Guillermo Cataño Cataño ◽  
Angela Marcela Mariño Alvarez ◽  
...  
Keyword(s):  
Prostate Biopsy ◽  
Infectious Complications ◽  
Rectal Swabs ◽  
Transrectal Prostate Biopsy

scholarly journals The Role of Saturation Transperineal Biopsy in the Diagnosis of Prostate Cancer in the Era of Targeted Fusion Biopsies

2018 ◽  
Vol 8 (2) ◽  
pp. 27-32
Author(s):  
A. A. Keln ◽  
A. V. Zyryanov ◽  
P. V. Zotov ◽  
A. V. Ponomarev ◽  
A. S. Surikov ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Biopsy ◽  
Imaging Techniques ◽  
Specific Antigen ◽  
Sufficient Information ◽  
Gleason Grading ◽  
Saturation Biopsy ◽  
Transrectal Prostate Biopsy ◽  
Degree Of Malignancy ◽  
Transperineal Biopsy

Introduction. One of the biggest problems in the diagnosis of prostate cancer (PCa), which distinguishes it from many other solid tumour conditions, is the difficulty of detecting the tumour using standard imaging techniques. The primary method of diagnosis of PCa, which allows timely treatment, is prostate biopsy. However, under certain clinical situations a saturation biopsy allows a more accurate prediction of the volume and degree of malignancy of the tumour, which can be used to plan the tactics of treatment.Materials and methods. 81 patients were examined, whose mean age was 63.5 ± 7.4. The average volume of the prostate was 59 ± 24.2 cm3 , while the average level of the prostate-specific antigen was 12.5 ± 8.9 ng/ml. All patients underwent at least one transrectal prostate biopsy. The average duration of the transperineal saturation biopsy of the prostate was 25.2 ± 7.4 minutes. The average number of biopsies was 25.Results and discussion. Based on the results of transperineal saturation biopsy, prostate cancer was detected in 34 patients (43.2 %). Adenocarcinoma was detected in all patients with confirmed malignant pathology. Gleason grading was 6 points in 22 (27.1 %) patients, 7 in 9 (9.9 %) and 8 in 4 (4.9 %). Aggressive tumour types (Gleason 7 and 8) corresponded to PIRADS 4 and 5. In PIRADS 2 and 3, 80 % and 50 %, respectively, manifested prostatic adenoma without malignant manifestation. Following radical prostatectomy, the results of a planned morphological conclusion were studied alongside biopsy data. It was determined that in 80.0 % (n = 12) of cases the tumour did not go beyond the prostate capsule and in only 20.0 % (n = 3) of cases was not confined to the prostate. The coincidence of diagnosis based on biopsy results and morphological conclusion was 86.7 %.Conclusion. The study showed that saturation transperineal biopsy is often a reference diagnostic method when, despite the presence of clinical suspicion of PCa, a standard biopsy, including targeted fusion biopsies, fails to provide sufficient information to confirm or exclude PCa. In such situations, the proposed technique provides an alternative approach, with a good frequency of detection of prostate cancer.

scholarly journals Antibiotic prophylaxis of acute postoperative endophthalmitis

2021 ◽  
Vol 21 (4) ◽  
pp. 220-226
Author(s):  
V.P. Nikolaenko ◽  
◽  
D.F. Belov ◽  
◽  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Povidone Iodine ◽  
Legal Aspects ◽  
Infectious Complications ◽  
Published Data ◽  
Antibacterial Prophylaxis ◽  
Postoperative Endophthalmitis ◽  
Bacterial Strains ◽  
Routes Of Administration ◽  
Causative Agents

This paper reviews current aspects of antibacterial prophylaxis of acute endophthalmitis, a dangerous complication of cataract surgery. The lack of a common standard for preventing phaco infectious complications, a growing number of resistant bacterial strains, and legal aspects of the lack of some antibiotic formulations and routes of their administration with established efficacy in Russia account for the importance of this issue. The authors provide a list of primary causative agents of endophthalmitis and specify their antimicrobial susceptibility, highlight the importance of using antiseptics to prevent endophthalmitis, and describe in detail routes of administration of antibiotics, including conventional ones (subconjunctival injections, topical use) and whose actively promoted (intracameral, transzonular). In conclusion, the authors suggested a rational antimicrobial preventive algorithm for endophthalmitis after phaco based on the analysis of recent Russian and foreign published data and adapted to the Russian health care system. Keywords: phacoemulsification, endophthalmitis, antiseptic, antibiotic, prophylaxis, antibacterial resistance, fluoroquinolones, aminoglycosides, povidone-iodine, intracameral administration. For citation: Nikolaenko V.P., Belov D.F. Antibiotic prophylaxis of acute postoperative endophthalmitis. Russian Journal of Clinical Ophthalmology. 2021;21(4):220–226 (in Russ.). DOI: 10.32364/2311-7729-2021-21-4-220-226.

scholarly journals Hepatitis C Transmission after Prostate Biopsy

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Karim Ferhi ◽  
Morgan Rouprêt ◽  
Pierre Mozer ◽  
Guillaume Ploussard ◽  
Alain Haertig ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Viral Transmission ◽  
Risk Of Infection ◽  
Ultrasound Probe ◽  
Transrectal Prostate Biopsy ◽  
A Current

Prostate biopsy is a current and well-codified procedure; antibiotic prophylaxis and rectal enema limit the risk of infection. To date, there has been no reported viral transmission between patients due to a contaminated ultrasound probe. In this study, we report the case of a patient who contracted the hepatitis C virus after transrectal prostate biopsy as part of an individual screening for prostate cancer.

Antibiotic prophylaxis for transrectal prostate biopsy

2007 ◽  
Author(s):  
Emerson L. Zani ◽  
Otavio Augusto Camara Clark ◽  
Nelson Rodrigues Netto Jr
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Transrectal Prostate Biopsy
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