Zhongwan(CV12) Acupoint Therapy Effect in B-Endorphin and C-Peptide in Induced Diabetic Male Rats

2017 ◽  
Vol 4 (3) ◽  
pp. 07
Author(s):  
R. Subbulakshmi ◽  
Girija Sivakumar ◽  
Sathiya Narayana Murthy
Keyword(s):  
Male Rats ◽  
Acupoint Therapy ◽  
C Peptide ◽  
Therapy Effect

scholarly journals Tilapia viscera hydrolysate extract alleviates oxidative stress and renal damage in deoxycorticosterone acetate-salt-induced hypertension rats

2020 ◽  
Vol 13 (11) ◽  
pp. 2477-2483
Author(s):  
Putut Har Riyadi ◽  
Mochammad Fitri Atho'illah ◽  
Wendy Alexander Tanod ◽  
Irma Sarita Rahmawati
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Inhibitory Concentration ◽  
Male Rats ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Therapy Effect ◽  
Renal Histology ◽  
Induced Hypertension ◽  
Glomerular Damage

Background and Aim: Hypertension is closely related to oxidative stress conditions, which increases malondialdehyde (MDA) expression and renal damage. Tilapia viscera hydrolysate extract (TVHE) contains compounds and peptides that act as antioxidants. This study aimed to investigate TVHE therapy effect on MDA levels and renal histological conditions in deoxycorticosterone acetate (DOCA)-salt-induced hypertension rats. Materials and Methods: Tilapia viscera were defatted and hydrolyzed using Alcalase enzyme to obtain TVHE. TVHE antioxidant activity was measured using the 1,1-diphenyl-2-picrylhydrazyl method. Fifteen Wistar male rats were divided into five groups: Normal control (without induced DOCA-salt), DOCA-salt, DOCA-salt+Captopril 5 mg/kg body weight (BW), DOCA-salt+TVHE 150 mg/kg BW, and DOCA-salt+TVHE 300 mg/kg BW. MDA level and renal histology were observed in each group. Results: TVHE half maximal inhibitory concentration values ranged from 3.87±0.35 μg/mL to 42.03±3.55 μg/mL, which were identified as in the very strong Blois category. TVHE and captopril therapy reduced MDA expression significantly (p<0.05) compared to DOCA-salt only. TVHE and captopril therapy also improved glomerular damage in DOCA-salt-induced hypertension rats. Conclusion: TVHE has antioxidant ability, decreased MDA level, and decreased glomerular damage in DOCA-salt-induced hypertension rats.

scholarly journals Evaluation of Antidiabetic Potentials of Morus mesozygia Linn. Stapf., Leaf Extracts in Streptozotocin-Induced Diabetic Rats

2020 ◽  
pp. 23-32
Author(s):  
Marcella Tari Joshua ◽  
Edna O. Wachuku ◽  
N. Boisa ◽  
Nsirim Nduka
Keyword(s):  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Male Rats ◽  
Controlled Study ◽  
Albino Rats ◽  
Dependent Manner ◽  
Leaf Extracts ◽  
Citrate Buffer ◽  
Standard Drug ◽  
C Peptide

Aim: The aim of this study therefore was to evaluate the antidiabetic potentials of Morus mesozygia Linn. Stapf., Leaf extrcts in Streptozotocin-Induced Diabetic Rats. Study Design:  The study is an experimental case-controlled study. Place and Duration of Study: This study was carried out at the Biochemistry Research Laboratory, University of Port Harcourt, Rivers State, Nigeria, between June 2018-April 2019. Methodology: A total of 65 male albino rats that weighed between 150g to 200g were used for this research study. Three different extracted solvents; aqueous, ethanolic and methanolic leaves extracts were administered to different groups of the rats. The male albino rats for this study were induced with a single dose of 40mg/kg b.wt, intraperitoneally of streptozotocin in 0.1M of citrate buffer, pH 4.5. The diabetic male rats were those whose fasting blood glucose (FBG) was from 250 mg/dl or 13 mmol/L and above. Results: The results showed that there were significant decreases (p<0.05) in, FBG, increased insulin and increased C-peptide and increased HOMA-IR concentration of induced diabetic male rats treated orally with 400 mg/kg of MMLS., when compared with the values of the diabetic male rats in treated orally with 200 mg/kg of MMLS., and non-significant decrease(p<0.05) in FBG, HOMA-IR increased insulin, increased C-peptide concentrations in the diabetic male rats treated orally for 30 days with 400 mg/kg in dose of methanolic leaves extracts of MMLS., in the group treated with 400 mg/kg methanol, when compared to the concentration of diabetic male in treated orally for 30 days with 200 mg/kg of methanolic leaves extracts of MMLS. Compared likewise with that treated with 100mg/kg of metformin standard drug. There were also significant decrease (p<0.05) in FBG, HOMA-IR, C-peptide and increased insulin concentrations in diabetic male rats treated with 200 mg/kg in dose of ethanolic and methanolic leaves extracts of MMLS., when compared with the values in the diabetic male rats treated orally with 400 mg/kg in dose of ethanolic and methanolic leaves extracts of MMLS., compared with values of diabetic male rats treated orally with 100mg/kg in dose of metformin standard drugs compared with the controls. Conclusion: From the findings of this study, we conclude that streptozotocin increased FBG levels, while the Methanolic, ethanolic and aqueous extracts of Morus mesozygia Linn. S improved FBG, C-peptide, insulin and HOMA levels in a dose-dependent manner, with the methanolic extract having the best ameliorative effect, probably due to its more phytochemical composition.

scholarly journals Effects of Berberine on Bloog Glucose, Glycated Hemoglobin A1, Serum Insulin, C–Peptide, Insulin Resistance and β– Cell Physiology

2020 ◽  
pp. 36-41
Author(s):  
Haji Khan Khoharo ◽  
Din Muhammad Shaikh ◽  
Ghulam Shah Nizamani ◽  
Tariq Zaffar Shaikh ◽  
Ikramuddin Ujjan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glycated Hemoglobin ◽  
Serum Insulin ◽  
Male Rats ◽  
Diabetic Rat ◽  
Cell Physiology ◽  
Β Cell ◽  
C Peptide ◽  
Hemoglobin A1 ◽  
Animal House

Objective: Determine effects of berberine (BBR) on bloog glucose, glycated hemoglobin A1, serum insulin, C – peptide, insulin resistance and β– cell physiology. Study Design: Experimental study Place and Duration: Department of Physiology Isra University and Animal house of Sindh Agriculture University, Tando Jam from August 2019 to February 2020. Methodology: A sample of 100 adult Wistar male rats was selected according to criteria of study and divided into 5 groups through random technique. Group A – negative controls (N/S 0.9%), Group B – positive control (diabetic rats – Alloxan 120 mg/kg) (i.p), Group C – E; Diabetic rat + BBR (50, 100 and 200 mg/kg) respectively. Blood samples were collected from retro-orbital venous plexus by capillary tube. Sera were separated at 3000 rpm (15 minutes). Insulin resistance (HOMA-IR) and β – cell secretory activity (HOMA-β) were calculated by mathematical formula. Statistical analysis was performed on SPSS version 21.0 (IBM, incorporation, USA) at 95% CI (P≤ 0.05). Results: The present study noted significant improvement of fasting and random blood glucose, glycated HbA1, serum insulin and C –peptide, insulin resistance (HOMA-IR) and β – cell physiology. Conclusion: Berberine (BBR) ameliorates the bloog glucose, glycated hemoglobin A1, serum insulin, c – peptide, insulin resistance and β– cell physiology.

scholarly journals Evidence of Anti-hyperglycemic and Anti-oxidant Effect of Passiflora edulis flavicarpa (Sims.) in Streptozotocin Induced Diabetic Rats

2015 ◽  
Vol 7 (4) ◽  
pp. 383-389 ◽  
Author(s):  
Subash PANCHANATHAN ◽  
Jayanthi RAJENDRAN
Keyword(s):  
Diabetes Mellitus ◽  
Total Antioxidant Status ◽  
Diabetic Rats ◽  
Male Rats ◽  
Enzymatic Antioxidants ◽  
Passiflora Edulis ◽  
C Peptide ◽  
Oxidative Markers ◽  
Total Antioxidant ◽  
Anti Oxidant

Diabetes mellitus is a worldwide problem and has no distinct cure. The present study was designed to investigate the antidiabetic, antioxidant and antilipidemic effects of Passiflora edulis flavicarpa extract (PefEt) against streptozotocin (STZ) induced diabetic rats. A total of forty wistar rats were randomly divided into four groups (n = 10 male rats/group) as control; control+PefEt; diabetic and diabetic + PefEt. Streptozotocin was administered as a single dose (50 mg/kg) to induce diabetes. The effect of Passiflora edulis flavicarpa (PefEt-250 mg/kg bodyweight for four weeks) on diabetic rats was investigated by evaluating various biochemical parameters. The levels of blood glucose, C-peptide, insulin; enzymatic antioxidants, total antioxidant status, oxidative markers (Malondialdehyde and Urinary 8-hydroxydeoxyguanosine) and lipid profile were measured. Levels of glucose, MDA and urinary 8-OHdG were significantly decreased, while levels of antioxidants, C-peptide and insulin were significantly increased on administration of PefEt in the STZ-induced rats when compared to control groups. Therefore, it could be concluded that PefEt must be considered as an excellent herb for future studies on diabetes mellitus.

Author response for "Mapping of the excitatory, inhibitory, and modulatory afferent projections to the anatomically defined active expiratory oscillator in adult male rats"

2020 ◽  
Author(s):  
Vivian Biancardi ◽  
Jashan Saini ◽  
Anileen Pageni ◽  
M. Hema Prashaad ◽  
Gregory D. Funk ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Author Response ◽  
Afferent Projections
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