scholarly journals Absolute leukocytes count and NLR as a diagnostic and prognostic biomarkers for severity of COVID-19 infection

2021 ◽  
Vol 10 (1) ◽  
pp. 03-05
Author(s):  
Khalid Abdelsamea Mohamedahmed ◽  
Adam Dawoud Abakar

The current COVID-19 pandemic challenges not only the lack of awareness of the disease, but also the rapid diagnosis, the prediction of severe early disease, the clinical characterization of mortality and severity of patients, and the effective management that affects the global scale, resulting in low capacities of healthcare systems, the resilience of systems and global economics. Therefore, early differential diagnosis and prediction of SARS-COV-2 infection severity are needed. CRP and NLR are diagnostic markers commonly used, most available, effective, and economically used primarily to evaluate the ongoing systemic inflammatory response.

2018 ◽  
Vol 54 (3) ◽  
pp. 179-184
Author(s):  
Weronika Kolasińska ◽  
Agnieszka Jankowska-Kulawy

Infections are quite common, especially in long-term hospitalized patients. Eearly differential diagnosis of severe bacterial and viral infections in patients in severe or critical condition is particularly important. Procalcitonin is a good and, above all, early marker of sepsis and generalized inflammatory states. 85% sensitivity and 91% specificity of this study were shown in the differentiation patients with systemic inflammatory response syndrome noninfectious and sepsis defined as a systemic inflammatory response syndrome induced by infection. The usage of procalcitonin assays in clinical algorithms may accelerate the diagnosis of infectious conditions, reduce the abuse of antibiotics and optimize therapy with these drugs. Therefore, the determination of procalcitonin concentration is increasingly used in clinical practice.


1998 ◽  
Vol 26 (Supplement) ◽  
pp. 56A
Author(s):  
Emanuel Rivers ◽  
Gregory Hays ◽  
Mohammed Amara ◽  
Barry Dereczyk ◽  
Michael Tomlanovich

Metabolites ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 359
Author(s):  
Giovana Colozza Mecatti ◽  
Salvador Sánchez-Vinces ◽  
Anna Maria A. P. Fernandes ◽  
Marcia C. F. Messias ◽  
Gabrielle K. D. de Santis ◽  
...  

Systemic inflammatory response syndrome (SIRS) and sepsis are two conditions which are difficult to differentiate clinically and which are strongly impacted for prompt intervention. This study identified potential lipid signatures that are able to differentiate SIRS from sepsis and to predict prognosis. Forty-two patients, including 21 patients with sepsis and 21 patients with SIRS, were involved in the study. Liquid chromatography coupled to mass spectrometry and multivariate statistical methods were used to determine lipids present in patient plasma. The obtained lipid signatures revealed 355 features for the negative ion mode and 297 for the positive ion mode, which were relevant for differential diagnosis of sepsis and SIRS. These lipids were also tested as prognosis predictors. Lastly, L-octanoylcarnitine was found to be the most promising lipid signature for both the diagnosis and prognosis of critically ill patients, with accuracies of 75% for both purposes. In short, we presented the determination of lipid signatures as a potential tool for differential diagnosis of sepsis and SIRS and prognosis of these patients.


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