THE PHASE DIAGRAM OF THE BINARY MEDICINAL CONDENSED SYSTEM «KETOPROFENPHENYLBUTAZONE»; ANTIINFLAMMATORY ACTIVITY OF THE BINARY EUTECTIC SYSTEM

Author(s):  
A.N. Seryakova ◽  
M.L. Tkachenko ◽  
Y.V. Moschenskyi
Author(s):  
M.L. Tkachenko ◽  
M.A. Loseva ◽  
L.E. Zhnyakina ◽  
A.V. Lyamin

2013 ◽  
Vol 739 ◽  
pp. 125-130
Author(s):  
Yan Fei Wang ◽  
Ya Wei Hou ◽  
Yue Wen Liu ◽  
Zuo Liang Sha

The phase diagram was experimentally determined by measuring the melting process for butylated hydroxytoluene (BHT)/paracresol system with differential scanning calorimeter (DSC). It was confirmed that this system is a binary eutectic system. Experimental results showed that the binary system is completely miscible in the liquid state and completely immiscible in the solid state. The compositions of the eutectic point were 28.37/ 71.63(BHT /Paracresol, mass percent) in the T-X phase diagram. The phase diagram data was modeled by different models, and it was found that Wilson model give better description of the experimental data.


1969 ◽  
Vol 37 (288) ◽  
pp. 459-465 ◽  
Author(s):  
H. C. Lin ◽  
W. R. Foster

SummaryThe system sanbornite-celsian has been investigated by the quenching method, and the results compared with earlier studies. The system is essentially a simple binary eutectic system with little or no solid solution. The eutectic is located at a composition of 69% sanbornite and 31% celsian (by weight) and at a temperature of 1227±3°C. No evidence for substantial solid solution of celsian in sanbornite, as reported in previous work, was found. Paracelsian, a naturally occurring polymorph of celsian, was not encountered in the study.


e-Polymers ◽  
2005 ◽  
Vol 5 (1) ◽  
Author(s):  
Jung-Sun Sohn ◽  
Soo-Kyung Choi ◽  
Byung-Wook Jo ◽  
Kirsten Schwark ◽  
Michael Hess

AbstractPaclitaxel is an antineoplastic agent derived from the bark of the Pacific Yew Tree (Taxus brevifolia). Oral administration of the pure drug is problematic as it has a poor absorption due to its poor solubility in aqueous media. A specific water-soluble prodrug - PP7 - has been introduced by coupling the drug with a water-soluble polymer. For any kind of medical application and administration, knowledge of the binary isobaric phase-diagram is important since it gives information about solubility, phase transitions and the corresponding compositions. The system PP7 + H2O was studied calorimetrically from -20°C and shows the typical behaviour of an eutectic system. The properties of the phase diagram are discussed in view of other solution properties of the system presented earlier.


1967 ◽  
Vol 89 (3) ◽  
pp. 230-233 ◽  
Author(s):  
R. H. Tien ◽  
G. E. Geiger

The solidification of a binary system differs from a pure metal in that the latent heat effect no longer occurs at the melting point but rather in a freezing zone between the liquidus and solidus temperatures. Such solidification is analyzed from a heat-transfer point of view. The system considered occupies a semi-infinite region, is initially at the liquidus temperature, and at all subsequent times the surface temperature is considered constant; the fraction solid is assumed to be linear with distance within the freezing zone between the solidus and liquidus. The heat released during solidification is treated as a discontinuous heat generation. This corresponds to the nonequilibrium freezing of a eutectic system. The temperature distribution and thickness of each region are calculated as a function of time using the error function solution and the heat-balance integral; the results are given in graphical form.


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