Evaluation of Three Models of Follow-up of Patients with Cervical Cytological Abnormalities in a Peruvian’s Largest Teaching Women’s Hospital

Abstract Background The purpose of this study was to compare cervical cancer screening by pap smear (PS) versus preliminary HPV testing based on self-collected samples (SC-HPV). Methods Interventional study among underprivileged women from 25 to 65 years old in four French cities. The control group (CG) was referred for a PS. The experimental group (EG) conducted a SC-HPV test followed by a PS in case of positivity. Differences on screening completion and cytological abnormalities were analysed by logistic and Cox regression. Results 383 women were assigned to the EG and 304 to the CG. The screening completion proportion was 39.5% in the CG compared to 71.3% in the EG (HR = 2.48 (CI 95% [1.99–3.08]; p < 0.001). The proportion of cytological abnormalities was 2.0% in the CG and 2.3% in the EG (OR = 1.20 (CI 95% [0.42–3.40]; p = 0.7). The proportion of participants lost to follow-up was 60.5% in the CG and 63.2% in the EG HPV positive (p = 0.18). Conclusion Providing an SC-HPV-test increased the participation of underprivileged women in CCS. Nevertheless, the significant number of lost to follow-up in both groups can undermine the initial benefits of the strategy for HPV positive women. Registration: Clinicaltrials.gov: NCT03118258.

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BELGIAN CONSENSUS GUIDELINES FOR FOLLOW-UP OF WOMEN WITH CERVICAL CYTOLOGICAL ABNORMALITIES

Acta Clinica Belgica ◽

10.1179/acb.2009.023 ◽

2009 ◽

Vol 64 (2) ◽

pp. 136-143 ◽

Cited By ~ 4

Author(s):

C. A. Cuvelier ◽

J.-P.M. Bogers ◽

C. Bourgain ◽

Ph. Delvenne ◽

M. Drijkoningen ◽

...

Keyword(s):

Consensus Guidelines ◽

Cytological Abnormalities

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hr-HPV testing in the follow-up of women with cytological abnormalities and negative colposcopy

British Journal of Cancer ◽

10.1038/bjc.2013.519 ◽

2013 ◽

Vol 109 (7) ◽

pp. 1766-1774 ◽

Cited By ~ 9

Author(s):

F Carozzi ◽

C B Visioli ◽

M Confortini ◽

A Iossa ◽

P Mantellini ◽

...

Keyword(s):

Hpv Testing ◽

Cytological Abnormalities

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Anal cytological abnormalities in HIV-infected homosexual men

International Journal of STD & AIDS ◽

10.1258/0956462981921017 ◽

1998 ◽

Vol 9 (1) ◽

pp. 37-40 ◽

Cited By ~ 8

Author(s):

S J Sayers ◽

A McMillian ◽

E Mcgoogan

Keyword(s):

Human Papillomavirus ◽

Anal Cancer ◽

Intraepithelial Neoplasia ◽

Heterosexual Men ◽

Homosexual Men ◽

Significant Difference ◽

Cytological Abnormalities ◽

Severe Degree ◽

Hiv Seropositive

Summary: This study aimed to examine the prevalence of anal cytological abnormalities in groups of HIV-infected and non-infected homosexual men, and to monitor changes with time. Dyskaryosis suggestive of anal intraepithelial neoplasia (AIN) was noted in 24 (30%) of the 80 satisfactory anal smears from 66 HIV-seropositive homosexual men; such changes were found in only 7 (4.7%) of the 149 satisfactory smears from 181 HIV-seronegative homosexual men ( P 0.005), and in none of 34 satisfactory preparations from 51 HIV-seronegative heterosexual men. In the follow-up of 20 HIV-seropositive men, the severity of the cytological abnormalities found in 2 men increased, with the most recent smear showing changes suggestive of AIN III; one of these men subsequently developed anal cancer. Smears from 4 men showed apparent regression in the degree of dyskaryosis. Although the numbers of patients studied were small, there appeared to be a trend towards a more severe degree of dyskaryosis in those men with increasing immunodeficiency. There was no significant difference in the detection of human papillomavirus types 6b, 11, 16 and 18 between HIV-infected and noninfected men. <

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