scholarly journals Phenylboronic Acid/CuSO4 as an Efficient Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazoles from Terminal Acetylenes and Alkyl Azides

2017 ◽  
Vol 59 (2) ◽  
Author(s):  
Heraclio López-Ruiz
Keyword(s):  
Microwave Heating ◽  
Room Temperature ◽  
Phenylboronic Acid ◽  
Terminal Alkynes ◽  
Efficient Catalyst ◽  
Alkyl Azides ◽  
Terminal Acetylenes

<p>The synthesis of 1,4-disubstituted-1,2,3-triazoles from alkyl azides and terminal alkynes at room temperature and under microwave heating was attained using Cu(I), generated <em>in-situ </em>from copper(II) sulfate and phenylboronic acid, as catalyst. Twelve new triazoles were obtained in moderate to good yields (53-98%), and the products were obtained by crystallization from the mixture reaction without further purification.</p>

An easily prepared palladium-hydrogel nanocomposite catalyst for C–C coupling reactions

2014 ◽  
Vol 2 (44) ◽  
pp. 18952-18958 ◽  
Author(s):  
Mitasree Maity ◽  
Uday Maitra
Keyword(s):  
Palladium Nanoparticles ◽  
Room Temperature ◽  
Coupling Reaction ◽  
Coupling Reactions ◽  
Sodium Cyanoborohydride ◽  
Efficient Catalyst ◽  
Suzuki Coupling Reaction ◽  
Reaction In Water ◽  
Hydrogel Nanocomposite

Palladium nanoparticles were efficiently prepared in situ by sodium cyanoborohydride reduction of Pd(ii) at room temperature using calcium-cholate hydrogel fibers as templates. The PdNPs self-organize on the gel fibers, which supports the controlled growth as well as stabilization of PdNPs. The hybrid xerogel was used as an efficient catalyst for the Suzuki coupling reaction in water.

A CU[I] CATALYZED MILD AND GENERAL SYNTHESIS OF 1,4-DISUBSTITUTED-1,2,3-TRIAZOLES FROM TERMINAL ACETYLENES AND IN SITU GENERATED ALKYL AZIDES

Heterocycles ◽  
2014 ◽  
Vol 89 (1) ◽  
pp. 27 ◽  
Author(s):  
Heraclio López-Ruiz ◽  
Susana Rojas-Lima ◽  
José Emilio de la Cerda-Pedro ◽  
Yoarhy Alejandro Amador-Sánchez ◽  
Mayra Cortés-Hernández ◽  
...  
Keyword(s):  
Alkyl Azides ◽  
Terminal Acetylenes ◽  
General Synthesis

scholarly journals One-Pot Synthesis of (Z)-β-Halovinyl Ketones via the Cascade of Sonogashira Coupling and Hydrohalogenation

2021 ◽  
Vol 8 ◽  
Author(s):  
Fa-Jie Chen ◽  
Zhenguo Hua ◽  
Jianhui Chen ◽  
Jiajia Chen ◽  
Daesung Lee ◽  
...  
Keyword(s):  
Efficient Method ◽  
Room Temperature ◽  
Copper Catalyst ◽  
High Yield ◽  
Sonogashira Coupling ◽  
Terminal Alkynes ◽  
Acid Chlorides ◽  
Triflic Acid ◽  
One Pot

Herein, we report an efficient method for the synthesis of (Z)-β-halovinyl ketones through a one-pot Sonogashira coupling and hydrohalogenation reaction promoted by palladium-copper catalyst and Brønsted acid. The ynone intermediates are generated in situ from readily available acid chlorides and terminal alkynes at room temperature, which are directly converted to (Z)-β-halovinyl ketones by treating with triflic acid. This method avoids the use of an external halogen source and features broad substrate scope, high yield, and good to excellent stereoselectivity.

scholarly journals Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes

2018 ◽  
Vol 14 ◽  
pp. 2916-2922 ◽  
Author(s):  
Muhammad Israr ◽  
Changqing Ye ◽  
Munira Taj Muhammad ◽  
Yajun Li ◽  
Hongli Bao
Keyword(s):  
Carboxylic Acids ◽  
Tandem Reaction ◽  
Reaction Synthesis ◽  
Terminal Alkynes ◽  
Alkyl Azides ◽  
Organic Azides ◽  
Cuaac Reaction ◽  
First Time

A copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and terminal alkynes is reported. The alkyl carboxylic acids is for the first time being used as the alkyl azide precursors in the form of alkyl diacyl peroxides. This method avoids the necessity to handle organic azides, as they are generated in situ, making this protocol operationally simple. The Cu(I) catalyst not only participates in the alkyl diacyl peroxides decomposition to afford alkyl azides but also catalyzes the subsequent CuAAC reaction to produce the 1,2,3-triazoles.

ChemInform Abstract: A Cu(I) Catalyzed Mild and General Synthesis of 1,4-Disubstituted-1,2,3-triazoles from Terminal Acetylenes and in situ Generated Alkyl Azides.

ChemInform ◽  
2014 ◽  
Vol 45 (24) ◽  
pp. no-no
Author(s):  
Heraclio Lopez-Ruiz ◽  
Susana Rojas-Lima ◽  
Jose Emilio de la Cerda-Pedro ◽  
Yoarhy Alejandro Amador-Sanchez ◽  
Mayra Cortes-Hernandez ◽  
...  
Keyword(s):  
Alkyl Azides ◽  
Terminal Acetylenes ◽  
General Synthesis

scholarly journals Mesoporous Silica-Supported Sulfonyldiamine Ligand for Microwave-Assisted Transfer Hydrogenation

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Shaheen M. Sarkar ◽  
Md. Eaqub Ali ◽  
Md. Shaharul Islam ◽  
Md. Lutfor Rahman ◽  
S. S. Rashid ◽  
...  
Keyword(s):  
Microwave Heating ◽  
Significant Loss ◽  
Transfer Hydrogenation ◽  
High Catalytic Activity ◽  
Efficient Catalyst ◽  
Microwave Assisted ◽  
Ru Complex ◽  
Simple Filtration ◽  
Diamine Ligands

N-Sulfonyl-1,2-diamine ligands, derived from 1,2-diaminocyclohexane and 1,2-diaminopropane, were immobilized onto mesoporous SBA-15 silica. The SBA-15-supported sulfonyldiamine-Ru complex was preparedin situunder microwave heating at 60 W for 3 min. The prepared sulfonyldiamine-Ru complex was used as an efficient catalyst for the transfer hydrogenation of ketones to the corresponding secondary alcohols. The heterogeneous complex showed extremely high catalytic activity with 99% conversion rate under microwave heating condition. The complexes were regenerated by simple filtration and reused two times without significant loss of activity.

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