scholarly journals Neurophysiological Changes in Patients with Discirculatory Encephalopathy Associated with Ischemic Optic Neuropathy

2020 ◽  
Vol 5 (4) ◽  
pp. 67-72
Author(s):  
T. N. Iureva ◽  
A. A. Zaika ◽  
V. V. Shprakh ◽  
S. I. Zhukova
Keyword(s):  
Optic Neuropathy ◽  
Visual Fields ◽  
Atherosclerotic Lesion ◽  
Oscillatory Potentials ◽  
Ischemic Optic Neuropathy ◽  
Visual Analyzer ◽  
Prevalence Index ◽  
Dyscirculatory Encephalopathy ◽  
Neck Vessels ◽  
The Brain

Background. The most common chronic cerebrovascular pathology is dyscirculatory encephalopathy, in which a decrease in blood supply due to damage to brachiocephalic vessels leads to damage to brain substances and analyzers, including visual, with the possible development of severe damage in the form of ischemic optic neuropathy. Many studies have been devoted to the relationship between atherosclerotic damage to the neck vessels and ischemic damage to the visual organ, but little attention has been paid to the study of the functional activity of the altered visual analyzer in patients with dyscirculatory encephalopathy, and the results are scattered. Aim. To conduct a comparative analysis of changes in neurophysiological parameters of the brain and visual analyzer in patients with dyscirculatory encephalopathy and patients with a combination of dyscirculatory encephalopathy and ischemic optic neuropathy. Materials and methods. 34 patients with the 2nd stage of dyscirculatory encephalopathy were examined and divided into two groups based on the presence/absence of ischemic optic neuropathy of various prescription periods. All patients underwent ultrasound scanning of neck vessels, visual fields determination, electroretinography, visual evoked potentials, and electroencephalogram. Results. The results revealed changes in a number of indicators in the group of patients with a combination of two diseases: more pronounced atherosclerotic lesion of brachiocephalic vessels, a decrease in the amplitude and the alpharhythm prevalence index, a decrease in oscillatory potentials, a change in latency and amplitudes the visual analyzer according, lengthening of time indicators with a simultaneous decrease in amplitudes and depression of retinal sensitivity. Conclusion. Patients with dyscirculatory encephalopathy complicated by ischemic optic neuropathy have a combined lesion of the brain and visual analyzer, which determines the severity of the detected changes and requires a comprehensive multidisciplinary approach to the treatment of these patients.

scholarly journals The anterior ischemic optic neuropathy treatment using the dispersed “Alloplant”

2013 ◽  
Vol 6 (2) ◽  
pp. 20-24
Author(s):  
Venera Uzbekovna Galimova ◽  
Irina Viktorovna Verzakova ◽  
Yevgeniy Musinovich Gareyev ◽  
Zarina Khikhmetullovna Karimova
Keyword(s):  
Visual Acuity ◽  
Visual Field ◽  
Blood Supply ◽  
Optic Neuropathy ◽  
Visual Fields ◽  
Resistance Index ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Ciliary Arteries ◽  
Lateral Branches

In this article, the results of a study are presented on the influence of the therapeutic retroscleral filling by dispersed “Alloplant” biomaterial upon blood supply and visual functions of the eye. 47 patients (69 eyes) suffering from anterior ischemic optic neuropathy sequelae were examined. Obtained results allowed to study the degree of relationship between the following indices: resistance index of ocular vessels, visual acuity and electrophysiological data, visual field limits. The majority of cases with significant visual fields widening (79 %) correlated with post-operative decrease of resistance index in posterior short ciliary arteries (medial and lateral branches). The results of performed investigation allow to assume that the dispersed “Alloplant” biomaterial use in the treatment of patients with anterior ischemic optic neuropathy sequelae could promote the optic nerve blood supply improvement with further amelioration of visual function indices.

scholarly journals Single Intravitreal Aflibercept Injection for Unilateral Acute Nonarteritic Ischemic Optic Neuropathy

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Ziya Ayhan ◽  
Gamze Kocaoğlu ◽  
Aylin Yaman ◽  
Meltem Söylev Bajin ◽  
A. Osman Saatci
Keyword(s):  
Optic Neuropathy ◽  
Elderly Population ◽  
Visual Fields ◽  
The Elderly ◽  
Ischemic Optic Neuropathy ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Intravitreal Aflibercept ◽  
Established Treatment

Acute nonarteritic ischemic optic neuropathy (ANAION) is the most common optic neuropathy in the elderly population without a well-established treatment. A 67-year-old man with a sudden painless visual loss in his left eye of one-day duration was diagnosed to have left ANAION. Next day, 2 mg aflibercept injection was injected intravitreally in OS. Visual acuity improved to 7/10 from 1/10 a week after the injection. Mean retinal nerve fiber layer thickness (RNFLT) was reduced to 159,7 μm from 182,4 μm at the first week. Visual fields improved dramatically during the follow-up of three months. The aim of this study is to present a case having ANAION treated with a single intravitreal aflibercept injection and discuss the place of intravitreal anti-VEGF injections in the treatment of armamentarium of ANAION.

Magnetic Resonance Imaging of the Brain in Nonarteritic Ischemic Optic Neuropathy

1995 ◽  
Vol 15 (3) ◽  
pp. 158???160 ◽  
Author(s):  
Anthony C. Arnold ◽  
Robert S. Hepler ◽  
D. Rex Hamilton ◽  
Robert B. Lufkin
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Resonance Imaging ◽  
The Brain

scholarly journals Visual Fields at Follow-up in the Ischemic Optic Neuropathy Decompression Trial

Ophthalmology ◽  
2008 ◽  
Vol 115 (10) ◽  
pp. 1809-1817 ◽  
Author(s):  
Roberta W. Scherer ◽  
Steven E. Feldon ◽  
Lori Levin ◽  
Patricia Langenberg ◽  
Joanne Katz ◽  
...  
Keyword(s):  
Optic Neuropathy ◽  
Visual Fields ◽  
Ischemic Optic Neuropathy

scholarly journals Use of Intravitreal Dexamethasone in a Case of Anterior Ischemic Optic Neuropathy

2017 ◽  
Vol 8 (2) ◽  
pp. 452-458 ◽  
Author(s):  
Raffaele Nuzzi ◽  
Francesca Monteu
Keyword(s):  
Visual Acuity ◽  
Optic Neuropathy ◽  
Visual Fields ◽  
Significant Loss ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
High Concentration ◽  
Acute Therapy ◽  
Systemic Corticosteroids ◽  
Intravitreal Dexamethasone

Nowadays there is no unique and well-established treatment for nonarteritic anterior ischemic optic neuropathy, despite being the main acute pathology that affects the optic nerve in the elderly population and often resulting in a significant loss of visual acuity. The effectiveness of oral steroids is still under debate in the international literature, although many studies show that patients treated with high doses of systemic corticosteroids have a significantly higher chance of improved visual acuity and visual fields. The authors propose an intravitreal dexamethasone injection/implant as initial and acute therapy. Compared to systemic corticosteroids, intravitreal dexamethasone has the advantage of avoiding any systemic side effects of steroids. On the other hand, a rise in intraocular pressure might occur, manageable with local antiglaucoma drugs, especially in patients at risk, and there is a risk of induced cataract. The pharmacodynamics of the intravitreal dexamethasone slow-release implant is characterized by a first step with high release concentrations and a second following phase with decreasing concentrations. Therefore, the use of emergency dexamethasone (high concentration) intravitreal injection is justified as a treatment after the first detection of an ischemic optic anterior neuropathy.

scholarly journals Neuroenergy Mapping Diagnostic Capabilities in Hypoxic Brain Lesions

2021 ◽  
Vol 6 (1) ◽  
pp. 1-6
Author(s):  
Alexandra Alexandrovna Maximova ◽  
Keyword(s):  
Cervical Spine ◽  
Developmental Disorders ◽  
Doppler Ultrasonography ◽  
X Rays ◽  
Hypoxic Brain ◽  
Dyscirculatory Encephalopathy ◽  
Diagnostic Capabilities ◽  
Neck Vessels ◽  
The Brain ◽  
Independent Cohort

Neuroenergy Mapping (NEM) is the topographic mapping of the brain’s energy metabolism by Direct Current Potentials (DCP). It allows an independent cohort of patients (18 children from 3 to 14 years old) with sharply reduced DCP in one or more areas of the cerebral cortex to be identified among children with diagnoses of ASD and other developmental disorders. Considering the experience of working with NEM and general clinical indications for children, there appeared to be a possibility of central circulatory disorders, and patients were referred for additional examinations. These included a Doppler ultrasonography of the brain and neck vessels and X-rays of the cervical spine in three projections. Results confirmed a diagnosis of dyscirculatory encephalopathy (I67.8) for 15 of the 18 patients. For 9 of these, blood circulation disorders were aggravated by identified disorders of the cervical spine. For 3 patients, the decrease in DCP was due to physiological vasospasm.

Blood rheology in acute anterior ischemic optic neuropathy

1991 ◽  
Vol 11 (6) ◽  
pp. 623-634 ◽  
Author(s):  
B. Bertram ◽  
A. Hoberg ◽  
O. Arend ◽  
S. Wolf ◽  
F. Jung ◽  
...  
Keyword(s):  
Optic Neuropathy ◽  
Blood Rheology ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy
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