177Lu-PSMA617 and the VISION Trial: One of the Greatest Success Stories in the History of Nuclear Medicine

2021 ◽  
Vol 62 (8) ◽  
pp. 1025-1026
Author(s):  
Johannes Czernin ◽  
Jeremie Calais
2004 ◽  
Vol 12 (4) ◽  
pp. 301-320
Author(s):  
Wolfgang Hetzer

AbstractThe imminent entry of ten countries into the European Union is one of the greatest success stories in the contemporary history of the continent. Following the devastation of the Second World War and the political and economic paralysis during the ‘Cold War’ period the future holds promise of development opportunities of historical significance for twenty-five Member States. It must not be overlooked, however, that, due to the still prevalent differences in living standards, in income ratios and in administrative structures, the process of economic approximation is also not without risks. Among these is the tendency towards corruption. The expansion of the European Union can only succeed economically and politically if the dangers associated with corruption are minimized by far-sighted legislation and consistent implementation measures throughout Europe. This is true not only with respect to the new Member States.


Author(s):  
Erinna F. Lee ◽  
W. Douglas Fairlie

The discovery of a new class of small molecule compounds that target the BCL-2 family of anti-apoptotic proteins is one of the great success stories of basic science leading to translational outcomes in the last 30 years. The eponymous BCL-2 protein was identified over 30 years ago due to its association with cancer. However, it was the unveiling of the biochemistry and structural biology behind it and its close relatives’ mechanism(s)-of-action that provided the inspiration for what are now known as ‘BH3-mimetics’, the first clinically approved drugs designed to specifically inhibit protein–protein interactions. Herein, we chart the history of how these drugs were discovered, their evolution and application in cancer treatment.


2021 ◽  
pp. 1-14
Author(s):  
Bo-Anders Jönsson
Keyword(s):  

Author(s):  
Mario Polèse

This chapter explores the attributes that help make local environments conducive to productive economic behavior. Several attributes are explored, beginning with integrity in local government and a short history of corruption and urban mismanagement in America, New Orleans serving as an instructive example. New Orleans’s sad story takes us back to Louisiana’s early history, the issue of race never far from the surface. The chapter also describes how the roots of Silicon Valley’s success go back to the California Gold Rush, helping to shape a unique institutional environment that promoted innovation. As the chapter explains, the unlikely success of Minneapolis-St. Paul, both peripheral and cold, can be traced back to Minnesota’s first settlers. Many of these early settlers were Scandinavian who traditionally placed a high value on education and work. Primary and secondary education matter as much, and often more, than PhDs. A competent and numerically literate workforce is at the core of many small and midsized urban success stories.


2018 ◽  
pp. 42-54
Author(s):  
Max Abrahms

This chapter revisits the most commonly cited examples in history of terrorism paying politically. If even these cases fail to illustrate the political effectiveness of terrorism then that would further undermine the evidentiary basis of the Strategic Model. Many scholars point to the political successes of the Irgun, African National Congress, and Hezbollah as evidence that terrorism is an effective instrument of coercion. Yet these campaigns did not coerce the occupying powers to withdraw by attacking their civilians. Instead, the groups focused their attacks on military and other government targets. This chapter shows that people overestimate the value of terrorist campaigns by lumping them together with guerrilla campaigns that have been far more successful.


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