Methyl-CpG-binding domain protein 2 - [Isoform 1]

2008 ◽  
Author(s):  
Lorenzo Chiariotti
Keyword(s):  
Binding Domain ◽  
Domain Protein

Identification of Human Methyl-CpG Binding Domain Protein (MBD) 4 as a Substrate of Protein Kinase X*

2012 ◽  
Vol 39 (11) ◽  
pp. 1109-1117
Author(s):  
Wei LI ◽  
Ying LIN
Keyword(s):  
Protein Kinase ◽  
Binding Domain ◽  
Domain Protein

scholarly journals Methyl-CpG-Binding Domain Protein MBD7 Is Required for Active DNA Demethylation in Arabidopsis

2015 ◽  
Vol 167 (3) ◽  
pp. 905-914 ◽  
Author(s):  
Chunlei Wang ◽  
Xiaomei Dong ◽  
Dan Jin ◽  
Yusheng Zhao ◽  
Shaojun Xie ◽  
...  
Keyword(s):  
Dna Demethylation ◽  
Binding Domain ◽  
Active Dna Demethylation ◽  
Domain Protein

scholarly journals Methyl-CpG binding domain protein 2 plays a causal role in breast cancer growth and metastasis

2020 ◽  
Author(s):  
Niaz Mahmood ◽  
Ani Arakelian ◽  
Moshe Szyf ◽  
Shafaat A. Rabbani
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Mammary Tumor ◽  
Tumor Burden ◽  
Tumor Formation ◽  
Binding Domain ◽  
Causal Role ◽  
Molecular Signaling ◽  
Primary Tumors ◽  
Domain Protein

AbstractMethyl-CpG-binding domain protein 2 (Mbd2), a reader of DNA-methylation, has been implicated in the progression of several types of malignancies, including breast cancer. To test whether Mbd2, which is overexpressed in human breast cancer samples and in MMTV-PyMT mammary pads, plays a causal role in mammary tumor growth and metastasis we depleted Mbd2 in transgenic MMTV-PyMT model of breast cancer by cross-breeding with Mbd2 knockout mice to generate heterozygous (PyMT;Mbd2+/-) and homozygous (PyMT;Mbd2-/-) animals. We found that Mbd2 depletion caused a gene dose-dependent delay in mammary tumor formation, reduced primary tumor burden, and lung metastasis at the experimental endpoint. In addition, animals from the PyMT;Mbd2-/- group survived significantly longer compared to the wildtype (PyMT;Mbd2+/+) and PyMT;Mbd2+/- arms. Transcriptomic and proteomic analyses of the primary tumors obtained from PyMT;Mbd2+/+ and PyMT;Mbd2+/- groups revealed that Mbd2 depletion alters several key determinants of the molecular signaling networks related to tumorigenesis and metastasis, which thereby demonstrate that Mbd2 is regulating transcriptional programs critical for breast cancer. To our knowledge, this is the first study demonstrating a causal role for a DNA-methylation reader in breast cancer. Results from this study will provide the rationale for further development of first-in-class targeted epigenetic therapies against Mbd2 to inhibit the progression of breast and other common cancers.

scholarly journals Identification and functional characterization of methyl-CpG binding domain protein from Tribolium castaneum

Genomics ◽  
2020 ◽  
Vol 112 (3) ◽  
pp. 2223-2232 ◽  
Author(s):  
Xiaowen Song ◽  
Yuemei Zhang ◽  
Qisheng Zhong ◽  
Keming Zhan ◽  
Jingxiu Bi ◽  
...  
Keyword(s):  
Tribolium Castaneum ◽  
Functional Characterization ◽  
Binding Domain ◽  
Domain Protein

scholarly journals Modulation of the activity of methyl binding domain protein 4 (MBD4/MED1) while processing iododeoxyuridine generated DNA mispairs

2009 ◽  
Vol 8 (12) ◽  
pp. 1156-1163 ◽  
Author(s):  
Mohammad Azhar Aziz ◽  
Jane E. Schupp ◽  
Timothy J. Kinsella
Keyword(s):  
Binding Domain ◽  
Domain Protein

scholarly journals Streptococcus gordonii Collagen-binding Domain Protein CbdA May Enhance Bacterial Survival in Instrumented Root Canals Ex Vivo

2013 ◽  
Vol 39 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Peter J. Moses ◽  
Daniel A. Power ◽  
Amy M. Jesionowski ◽  
Howard F. Jenkinson ◽  
Eugene A. Pantera ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Binding Domain ◽  
Streptococcus Gordonii ◽  
Bacterial Survival ◽  
Collagen Binding ◽  
Root Canals ◽  
Domain Protein
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