The article presents the results on qualitative and quantitative indicators of phytoplankton of the Prut River lower sector within the Republic of Moldova in 2018-2020. In phytoplankton compositions 72 species were identified. Seasonal and long-term patterns of phytoplankton development have been established in Prut River lower sector. The numbers of phytoplankton changed within the limits 1,06 to 20,32 mln. cell/l, with biomass 1,23-21,64 g/m3. The values of saprobic indexes, estimated on the basis of species-indicators (52 species) from phytoplankton composition, which are in proportion of 58% typically β-mezosaprobic, confirm the following: the water quality of lower Prut River sector in the period 2018-2020 was satisfactory for the development of phytoplankton and was attributed mainly to II-III (good-moderately polluted) quality classes.