Field experiment was conducted at University of Uyo Teaching, research farm during the 2018 and 2019 cropping seasons to assess the effect of fertilization on cocoyam-based intercropping systems. The experiment was laid out in a randomized complete block design with three replications. Treatments were six fertilizers rates - 0kg/ha, NPK200kg/ha, NPK400kg/ha, PM2.5t/ha, PM5.0t/ha, Mixture (NPK200kg/ha + PM2.5t/ha) and six crop mixtures - Sole Cocoyam, Sole Melon, Sole Maize, Cocoyam + Maize, Cocoyam + Melon and Cocoyam + Melon + Maize). Result analysed with analysis of variance revealed PM2.5t/ha, NPK400kg/ha and Mixture (NPK200kg/ha + PM2.5t/ha) gave higher plant height, leaf area, stem girth in sole cocoyam, maize and melon respectively. PM2.5t/ha favoured leaf area, stem girths of cocoyam, maize with cocoyam + maize, cocoyam + melon and cocoyam + melon + maize crop mixtures. PM5.0t/ha gave higher values of corm, cormels, cormels weight, cormels number and cormels length in both sole cocoyam and mixtures (cocoyam + melon, cocoyam + maize, cocoyam + melon + maize) in both seasons respectively. PM2.5t/ha gave higher values of maize grain yield with cocoyam + maize, cocoyam + melon + maize crop mixtures. PM5.0t/ha and NPK400kg/ha gave higher melon seed values with cocoyam + melon and cocoyam + Melon + maize. Conclusively, it is recommended that application of organic fertilizer promotes higher yields and yield components in both sole and crop mixtures of cocoyam and maize respectively.