With the development of printing and dyeing industry, the nation has become the world's largest dye production and use country. With the complex composition and high color, the dyeing wastewater was currently recognized as one of the more difficult industrial wastewater to deal with. The bentonites was modified by PDMDAAC and applied into the treatment of dyeing wastewater. The treatment process was optimized with the index of decoloration rate. The decoloration rate reached 99.76% under the optimized conditions of adsorbent dosage=2g/L, pH=11, adsorption time=80min, stirring speed=350r/min, solution concentrate=500mg/L. The orthogonal experiment was designed to investigate the interaction between various reaction conditions. The superiority of PDMDAAC modified bentonite was confirmed by the comparing experiment.