scholarly journals Determination of twenty chemical element contents in normal and goitrous thyroid using X-ray fluorescent and neutron activation analysis

2021 ◽  
Vol 11 (2) ◽  
pp. 130-146
Author(s):  
Vladimir Zaichick
Keyword(s):  
Neutron Activation Analysis ◽  
Activation Analysis ◽  
Neutron Activation ◽  
Chemical Elements ◽  
Thyroid Tissue ◽  
Nodular Goiter ◽  
Tissue Samples ◽  
X Ray ◽  
Important Health ◽  
Non Destructive

Nodular goiter (NG) is an internationally important health problem. The aim of this exploratory study was to examine the content of silver (Ag), bromine (Br), calcium (Ca), chlorine (Cl), cobalt (Co), chromium (Cr), cooper (Cu), iron (Fe), mercury (Hg), iodine (I), potassium (K), magnesium (Mg), manganese (Mn), sodium (Na), rubidium (Rb), ammonium (Sb), scandium (Sc), selenium (Se), strontium (Sr), and zinc (Zn) in the normal thyroid and in the thyroid tissues with diagnosed colloid NG.. Thyroid tissue levels of twenty chemical elements (ChE) were prospectively evaluated in 46 patients with NG and 105 healthy inhabitants. Measurements were performed using non-destructive energy-dispersive X-Ray fluorescent analysis combined with instrumental neutron activation analysis with high resolution spectrometry of short– and long-lived radionuclides. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for ChE analysis. It was found that during a goitrous transformation the levels of Ag, Br, Cl, Co, Cu, Fe, Hg, Mg, Na, and Sc in thyroid tissue significantly increased, whereas the levels of I and Sr decrease. It was supposed that the changes in levels Ag, Br, Cl, Co, Cu, Fe, Hg, I, Mg, Na, Sc, and Sr in thyroid tissue can be used as NG markers.

scholarly journals Comparison of Chemical Element Contents in Thyroid Goiter, Adenoma, and Thyroiditis investigated using Neutron Activation Analysis

2021 ◽  
Vol 12 (3) ◽  
pp. 098-107
Author(s):  
Vladimir Zaichick
Keyword(s):  
Neutron Activation Analysis ◽  
Activation Analysis ◽  
Neutron Activation ◽  
Chemical Elements ◽  
Thyroid Tissue ◽  
Therapeutic Interventions ◽  
Endocrine Gland ◽  
Clear Understanding ◽  
Tissue Samples ◽  
Normal Thyroid

Thyroid benign nodules (TBNs) are the most common lesions of this endocrine gland. Among TBNs the colloid goiter (CG), thyroiditis (T), and thyroid adenoma (TA) are the most frequent diseases. An evaluation of the variant of TBNs is clinically important for subsequent therapeutic interventions, as well as for more clear understanding the etiology of these disorders. The aim of this exploratory study was to examine differences in the content of bromine (Br), calcium (Ca), chlorine (Cl), iodine (I), potassium (K), magnesium (Mg), manganese (Mn), and sodium (Na) in tissues of CG, TA, and T. Thyroid tissue levels of eight chemical elements (ChE) were prospectively evaluated in 46 patients with CG, 19 patients with TA, and 12 patients with T. Measurements were performed using non-destructive instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for ChE analysis. It was observed that in CG, TA and T tissues content of Br was significantly higher, while level of I was lower than in normal thyroid tissue. I accumulation in T tissue was lower than in normal thyroid and CG. Abnormal increase in Br level and decrease in I level in all TBNs might demonstrate an involvement of these ChE in etiology and pathogenesis of TBNs. It was suosed that great losses of I in thyroid with T, in contract to little reduced levels of I content in thyroid with CG and TA, could possibly be explored for differencial diagnosis of T.

scholarly journals COMPARISON BETWEEN BROMINE, CALCIUM, CHLORINE, IODINE, POTASSIUM, MAGNESIUM, MANGANESE, AND SODIUM CONTENTS IN MACRO- AND MICRO-FOLLICULAR COLLOID GOITER

2021 ◽  
pp. 5-9
Author(s):  
VLADIMIR ZAICHICK
Keyword(s):  
Mass Fraction ◽  
Chemical Elements ◽  
Thyroid Tissue ◽  
Nodular Goiter ◽  
Control Group ◽  
Common Disease ◽  
Tissue Samples ◽  
Normal Thyroid ◽  
Non Destructive ◽  
Potassium Magnesium

Objective: Colloid nodular goiter (CNG) is the most common disease of the thyroid, even in non-endemic regions, but the etiology of CNG is unclear. It is known that not merely iodine (I) but other chemical elements (ChE) are involved in goitrogenesis. The current study was performed to clarify the preferential accumulation of some ChE either in the colloid or in cells of the thyroid gland. Methods: Eight ChE: Bromine, calcium, chlorine (Cl), I, potassium, magnesium, manganese, and sodium (Na) in the thyroid tissues with diagnosed CNG were prospectively evaluated in 16 patients with macrofollicular CNG and 13 patients with microfollicular CNG. The control group included thyroid tissue samples from 105 healthy individuals. Measurements were conducted using non-destructive instrumental neutron activation analysis with high-resolution spectrometry of short-lived radionuclides. Results: It was found that in macrofollicular CNG, the mass fraction of Cl and Na was 2.57 and 1.82 times, respectively, higher than in tissues of the normal thyroid. In microfollicular CNG, the mass fraction of I was 59% lower, whereas the mass fraction of Na was 67% higher than in tissues of the normal thyroid. The level of I in macrofollicular goiter was 2.08 times higher than in microfollicular goiter Conclusion: There are substantial changes in ChE contents in the goitrous transformed tissue of the thyroid, which depend on the histology of the goiter.

scholarly journals Evaluation of Ten Trace Elements in Riedel’s Struma Using Neutron Activation Analysis

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
V Zaichick
Keyword(s):  
Trace Elements ◽  
Neutron Activation Analysis ◽  
Instrumental Neutron Activation Analysis ◽  
Activation Analysis ◽  
Neutron Activation ◽  
Exploratory Study ◽  
Thyroid Tissue ◽  
Mean Values ◽  
Non Destructive

Aims: Role of trace elements (TE) in etiology and pathogenesis of Riedel’s disease (RD) is unclear. The aim of this exploratory study was to assess whether there were significant changes in thyroid tissue levels of ten TE (Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn) are present in the fibrotic transformed thyroid. Methods: Ten TE of thyroid tissue were determined in 6 patients with RD and 105 healthy populations. The measurements were performed using non-destructive instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides. Results: Elevated mean values of Rb content were found in thyroid with RD in comparison with normal level. Conclusions: There are considerable changes in Rb content in tissue of thyroid with RD. Thus, it is reasonable to assume that the level of Rb in thyroid tissue can be used as RD markers. However, this topic needs additional studies.

Trace Element Contents in Thyroid Cancer Investigated by Instrumental Neutron Activation Analysis

2018 ◽  
Vol 1 (1) ◽  
pp. 1-13
Keyword(s):  
Thyroid Cancer ◽  
Neutron Activation Analysis ◽  
Instrumental Neutron Activation Analysis ◽  
Activation Analysis ◽  
Neutron Activation ◽  
Trace Element ◽  
Thyroid Tissue ◽  
Tissue Levels ◽  
Trace Element Contents ◽  
Element Contents

Background: Thyroid cancer is an internationally important health problem. The aim of this exploratory study was to evaluate whether significant changes in the thyroid tissue levels of Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn exist in the malignantly transformed thyroid. Methods: Thyroid tissue levels of ten trace elements were prospectively evaluated in 41 patients with thyroid malignant tumors and 105 healthy inhabitants. Measurements were performed using non-destructive instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for trace element analysis. Results: It was found that contents of Ag, Co, Cr, Hg, and Rb were significantly higher (approximately 12.8, 1.4, 1.6, 19.6, and 1.7 times, respectively) in cancerous tissues than in normal tissues. Conclusions: There are considerable changes in trace element contents in the malignantly transformed tissue of thyroid.

Non-Destructive neutron activation analysis of zircons from different genetic types

1977 ◽  
Vol 36 (2) ◽  
pp. 479-490 ◽  
Author(s):  
Hafez S. Abdel Wahab ◽  
J. Bérczi ◽  
L. Bognár ◽  
G. Keömley
Keyword(s):  
Neutron Activation Analysis ◽  
Activation Analysis ◽  
Neutron Activation ◽  
Genetic Types ◽  
Non Destructive
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