scholarly journals Blood Pressure Reference Intervals for Ketamine-sedated Rhesus Macaques (Macaca mulatta)

Author(s):  
Rachel D Brownlee ◽  
Philip H Kass ◽  
Rebecca L Sammak

Appropriate calculation and use of reference intervals have widespread clinical and research implications. Unfortunately, reference intervals for blood pressure in one of the most commonly used NHP species, rhesus macaques (Macaca mulatta), have never been calculated. Although anesthetic drugs and noninvasive methods of blood pressure measurement both have known effects on blood pressure values, their use provides the safest, fastest, and most widely used approach to clinical evaluation and blood pressure collection in this species. We analyzed noninvasive blood pressure measurements from 103 healthy, ketamine-sedated, adult (age, 8 to 16 y) rhesus macaques, representing both sexes, with various body condition scores by using 2 types of sphygmomanometers at 3 different anatomic locations. Reference intervals were calculated for each device, in each location, thus establishing normative data beneficial to clinical veterinarians assessing animal health and encouraging researchers to use noninvasive methods. Age, body condition score, sex, type of sphygmomanometer, and location of cuff placement were all found to influence blood pressure measurements significantly, providing important information necessary for the appropriate interpretation of noninvasive blood pressure values in rhesus macaques.

2019 ◽  
Vol 27 (1) ◽  
pp. 114-125 ◽  
Author(s):  
Esther J. Varney ◽  
Ashley M. Van Drunen ◽  
Emily F. Moore ◽  
Kristen Carlin ◽  
Karen Thomas

Background and PurposeBlood pressure measurement represents the pressure exerted during heart ejection and filling. There are several ways to measure blood pressure and a valid measure is essential. The purpose of this study was to evaluate the approach to noninvasive blood pressure measurement in children.MethodsBlood pressure measurements were taken using the automatic Phillips MP30 monitor and compared against Welch Allyn blood pressure cuffs with Medline manual sphygmomanometers.ResultsA total of 492 measurements were taken on 82 subjects, and they demonstrated comparability between automatic and manual devices.ConclusionsAlthough our study indicated acceptable agreement between automatic and manual blood pressure measurement, it also revealed measurement error remains a concern, with sample size, study protocol, training, and environment all playing a role.


1996 ◽  
Vol 80 (1) ◽  
pp. 307-314 ◽  
Author(s):  
R. P. Schnall ◽  
N. Gavriely ◽  
S. Lewkowicz ◽  
Y. Palti

A new noninvasive measurement method providing rapid measurement of systemic arterial blood pressure (BP) and its validation is described. The method combines precisely timed electrocardiographic-gated rapid release of occluding counter-pressure (600 mmHg/s) with photoplethysmographic detection of radial artery filling to measure arterial opening pressure. A complete BP waveform is reconstructed from multiple repetitions of the measurement cycle at successively increasing time intervals relative to the electrocardiographic signal. Systolic and diastolic values can be measured within two to four cardiac cycles at the peak and trough of the BP wave. The new method was compared with sphygmomanometry in 26 randomly selected subjects over a sphygmomanometric pressure range of 53-110 (diastolic) and 100-190 mmHg (systolic). The mean pressure differences between the sphygmomanometric and new methods were -1.3 +/- 15.2 (SD) (systolic) and 0.7 +/- 9.9 mmHg (diastolic), and corresponding BP values measured by these methods were highly correlated [P < 0.001; R2 = 0.87 (systolic); R2 = 0.80 (diastolic)]. The new method was compared with sphygmomanometry and intra-arterial BP in six patients. These tests confirmed the method's validity compared with established methods. The new method was ostensibly immune to mechanical perturbations when tested during cycle ergometry at 60 W. The new method may facilitate the study of circulatory phenomena previously inaccessible by available noninvasive methods and minimizes patient discomfort and circulatory arrest at the measurement site.


2021 ◽  
Vol 7 (1) ◽  
pp. 8
Author(s):  
Mariña González-Pena ◽  
Juan A. Castro-García ◽  
Alberto J. Molina-Cantero ◽  
Manuel Merino-Monge ◽  
Isabel M. Gómez-González

The correct diagnosis of high blood pressure is important to avoid cardiovascular diseases. In this work, we propose a low-cost noninvasive blood-pressure measurement unit composed of a photoplethysmograph and an electrocardiograph. It is based on pulse transit time measurement, thus performing nonocclusive measurement. To test the effectiveness of this parameter, a total of five subjects were measured, verifying their effectiveness at all times.


Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Mekala R Raman ◽  
Jonathan Graff-Radford ◽  
Scott A Przybelski ◽  
Timothy G Lesnick ◽  
Michelle M Mielke ◽  
...  

Hypertension is highly prevalent in the elderly population and microinfarcts are the most common vascular brain pathology identified in older adults at autopsy. We investigated the associations between systolic and diastolic blood pressures measured antemortem and the presence of microinfarcts at autopsy. Study subjects (n=302; age range=71-95) were participants in the population-based Mayo Clinic Study of Aging autopsy study, who had blood pressure measurements recorded during life. We investigated both cross-sectional systolic and diastolic blood pressure measurements at the baseline visit and the change in blood pressure (slope). Presence and location (subcortical or cortical) of chronic microinfarcts was abstracted from the autopsy reports. Of the 302 study subjects, 47 (16%) had cerebral microinfarcts, and, of those, 18 (38%) had subcortical microinfarcts and 29 (62%) had only cortical microinfarcts. The baseline blood pressures were not different between subjects with no microinfarcts, subcortical microinfarcts, and only cortical microinfarcts. In a logistic regression model including time between last blood pressure measurement and death, a greater decline in systolic [OR= 1.06 (1.01, 1.11); p=0.02]) and greater decline in diastolic [OR= 1.11 (1.02, 1.20); p=0.01] blood pressures were predictors of the presence of subcortical microinfarcts at autopsy. However, these variables were not associated with the presence of cortical microinfarcts. In conclusion, microinfarcts are common in the older adult population, and most of them are located in the cortex. A greater decline in both systolic and diastolic blood pressures and their association with subcortical microinfarcts, but not with cortical microinfarcts, may have implications for aggressive lowering of blood pressure in the elderly population.


PEDIATRICS ◽  
1977 ◽  
Vol 59 (5) ◽  
pp. 788-789
Author(s):  
A. Frederick North

Dr. Shiela Mitchell and her distinguished committee recommended in the July 1975 issue that blood pressure measurements should be a regular and routine part of every physical examination of every child over the age of 2. They recommended that any child with a blood pressure over the 95th percentile for age have a fundoscopic examination and at least one repeated blood pressure measurement and clinical evaluation within a few weeks. They stated that repeated examinations and further investigations are indicated if the blood pressure persists at or above the 95th percentile.


1993 ◽  
Vol 4 (1) ◽  
pp. 66-80 ◽  
Author(s):  
Deborah A. Gorny

Arterial blood pressure (BP) measurements, which include invasive direct methods and noninvasive indirect methods, provide a picture of the hemodynamic status of the patient. Invasive BP methods measure pressure pulse wave amplitude; noninvasive methods rely on blood flow or arterial wall motion as a basis for the determination of BP values. To obtain the most accurate BP value, the clinician must identify which measurement variables in a specific clinical situation are most contributory to error and, if possible, use a method of measurement for which the sources of error are not parallel. Blood pressure values obtained by different methods cannot be compared without a thorough understanding of the user-related and instrumentation-related limitations associated with each BP measurement technique


Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Kathryn Foti ◽  
Lawrence J Appel ◽  
Kunihiro Matsushita ◽  
Josef Coresh ◽  
G Caleb Alexander ◽  
...  

Introduction: Clinical practice guidelines emphasize the importance of accurate blood pressure measurement and recording to diagnose and treat hypertension. Trends in terminal digit preference (typically manifest by a terminal digit of ‘0’) have not been examined nationally. The growing use of automated blood pressure devices may have reduced terminal digit preference and improved accuracy over time. Objective: To evaluate trends in terminal digit preference in office blood pressure measurements among adults with hypertension by patient and provider characteristics. Methods: We used IQVIA National Disease and Therapeutic Index (NDTI) data from January 2014 through June 2019. The NDTI is designed to be nationally-representative of all patient visits to office-based physicians and uses a two-stage stratified sampling design to sample ~4,000 physicians per quarter who report information on all patient visits on 2 random workdays. We included all hypertension treatment visits (~60M/year) among adults aged ≥18. We examined trends in the proportion of hypertension treatment visits with recorded systolic (SBP) and diastolic (DBP) blood pressure measurements with a terminal digit ‘0’. The expected percent of blood pressures with ‘0’ is 10% for automated and 20% for manual readings. Results: There was a decrease in the percent of visits with SBP (43.0% to 37.4%) or DBP (44.3% to 38.1%) recordings ending in zero ( Table ). The decrease in percent of SBPs with a terminal zero was similar by patient and provider characteristics, though the percentage of SBPs with a terminal ‘0’ was consistently higher among patients aged ≥60, when SBP ≥140 mmHg, and among cardiologists. Conclusions: Terminal digit preference is common indicating systematic error in blood pressure measurement and recording, despite some improvement over time. This may lead to under- and overtreatment of patients with hypertension. Improving the quality of blood pressure measurement is central to improving hypertension diagnosis and control in clinical practice.


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