Acetylcholine Chloride

2021 ◽  
Keyword(s):  
Acetylcholine Chloride

Interaction of Acetylcholine Chloride with IAA, GA 3 and Red Light in the Growth of Excised Apical Coleoptile Segments

1978 ◽  
Vol 105 (3) ◽  
pp. 187 ◽  
Author(s):  
Verna R. Lawson ◽  
Ruth M. Brady ◽  
Annette Campbell ◽  
Brenda G. Knox ◽  
Glenda D. Knox ◽  
...  
Keyword(s):  
Red Light ◽  
Acetylcholine Chloride

STEREOSPECIFICITY IN THE ENZYMATIC HYDROLYSIS OF TABUN AND ACETYL-β-METHYLCHOLINE CHLORIDE

1955 ◽  
Vol 33 (1) ◽  
pp. 963-969 ◽  
Author(s):  
F. C. G. Hoskin ◽  
G. S. Trick
Keyword(s):  
Enzymatic Hydrolysis ◽  
Enzymatic Reaction ◽  
Brain Homogenate ◽  
Serum Enzyme ◽  
Rat Serum ◽  
Bicarbonate Buffer ◽  
First Order ◽  
Acetylcholine Chloride ◽  
Hydrolysis Of ◽  
Enzyme Source

The hydrolysis of the powerful cholinesterase inhibitor, tabun, at pH 7 to 7.5 by a rat serum enzyme in bicarbonate buffer involves two simultaneous first-order reactions. A fast, enzyme-catalyzed reaction destroys the toxic dextrorotatory isomer of tabun. The much slower hydrolysis of the levorotatory and apparently non-toxic isomer is probably a non-enzymatic reaction. The enzymatic hydrolysis of acetyl-dl-β-methylcholine chloride by a rat brain homogenate has been studied as a model reaction. Only one-half of the racemic compound is hydrolyzed in contrast to the complete hydrolysis of acetylcholine chloride by the same enzyme source. These results and the results of toxicity studies on the hydrolyzing solution indicate that true cholinesterase hydrolyzes only the dextrorotatory isomer of acetyl-dl-β-methylcholine chloride.

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