The Role of Uterus from Perspective of Improving Fertility, Periconceptional Outcomes and Developmental Programming with the Concept of Developmental Origins of Health and Disease (DOHaD)

Maternal prenatal diet can exert a powerful influence on the health of children when they reach adulthood – an orienting phenomenon in the Developmental Origins of Health and Disease research paradigm. Similar to other subsistence-based communities experiencing a rapid nutrition transition, obesity is increasing among Yup’ik Alaskans. Diabetes prevalence, however, remains relatively low and may reflect developmental nutritional processes that have yet to be thoroughly considered. Here we investigate recall of Yup’ik women’s diets during a past pregnancy using a mixed-methods approach as a critical first step in exploring such alternative developmental hypotheses. For certain populations, retrospective dietary reports might be the only source of information on factors relevant to understanding developmental pathways to health and disease. Our analysis identified community-specific factors that will likely improve the accuracy of future retrospective dietary analyses investigating the role of prenatal nutrition in the developmental origins of metabolic disease, especially among Alaska Natives.

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Metabolomics in the developmental origins of obesity and its cardiometabolic consequences

Journal of Developmental Origins of Health and Disease ◽

10.1017/s204017441500001x ◽

2015 ◽

Vol 6 (2) ◽

pp. 65-78 ◽

Cited By ~ 26

Author(s):

M. F. Hivert ◽

W. Perng ◽

S. M. Watkins ◽

C. S. Newgard ◽

L. C. Kenny ◽

...

Keyword(s):

Life Course ◽

Potential Role ◽

Human Populations ◽

Developmental Origins ◽

Excess Adiposity ◽

Health And Disease ◽

The Life Course ◽

Analytical Approaches ◽

Review Current

In this review, we discuss the potential role of metabolomics to enhance understanding of obesity-related developmental origins of health and disease (DOHaD). We first provide an overview of common techniques and analytical approaches to help interested investigators dive into this relatively novel field. Next, we describe how metabolomics may capture exposures that are notoriously difficult to quantify, and help to further refine phenotypes associated with excess adiposity and related metabolic sequelae over the life course. Together, these data can ultimately help to elucidate mechanisms that underlie fetal metabolic programming. Finally, we review current gaps in knowledge and identify areas where the field of metabolomics is likely to provide insights into mechanisms linked to DOHaD in human populations.

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Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol?

International Journal of Molecular Sciences ◽

10.3390/ijms19092584 ◽

2018 ◽

Vol 19 (9) ◽

pp. 2584 ◽

Cited By ~ 17

Author(s):

You-Lin Tain ◽

Chien-Ning Hsu

Keyword(s):

Metabolic Syndrome ◽

Early Life ◽

Wide Spectrum ◽

Molecular Targets ◽

Developmental Programming ◽

Developmental Origins ◽

Polyphenolic Compound ◽

Beneficial Effects ◽

The Metabolic Syndrome ◽

Health And Disease

Metabolic syndrome (MetS) is a mounting epidemic worldwide. MetS can start in early life, in a microenvironment that is now known as the developmental origins of health and disease (DOHaD). The concept of DOHaD also offers opportunities for reprogramming strategies that aim to reverse programming processes in early life. Resveratrol, a polyphenolic compound has a wide spectrum of beneficial effects on human health. In this review, we first summarize the epidemiological and experimental evidence supporting the developmental programming of MetS. This review also presents an overview of the evidence linking different molecular targets of resveratrol to developmental programming of MetS-related disorders. This will be followed by studies documenting resveratrol as a reprogramming agent to protect against MetS-related disorders. Further clinical studies are required in order to bridge the gap between animal models and clinical trials in order to establish the effective dose and therapeutic duration for resveratrol as a reprogramming therapy on MetS disorders from developmental origins.

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The Role of Epigenetics in the Developmental Origins of Health and Disease

Epigenetic Epidemiology ◽

10.1007/978-94-007-2495-2_7 ◽

2011 ◽

pp. 105-116 ◽

Cited By ~ 4

Author(s):

Karin B. Michels ◽

Robert A. Waterland

Keyword(s):

Developmental Origins ◽

Health And Disease

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Developmental Origins of Adult Health and Disease: The Role of Periconceptional and Foetal Nutrition

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/j.1742-7843.2007.00188.x ◽

2008 ◽

Vol 102 (2) ◽

pp. 82-89 ◽

Cited By ~ 158

Author(s):

I. Caroline McMillen ◽

Severence M. MacLaughlin ◽

Beverly S. Muhlhausler ◽

Sheridan Gentili ◽

Jaime L. Duffield ◽

...

Keyword(s):

Developmental Origins ◽

Adult Health ◽

Health And Disease

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The common marmoset monkey: avenues for exploring the prenatal, placental, and postnatal mechanisms in developmental programming of pediatric obesity

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00164.2017 ◽

2018 ◽

Vol 314 (5) ◽

pp. R684-R692 ◽

Cited By ~ 4

Author(s):

Laren Riesche ◽

Suzette D. Tardif ◽

Corinna N. Ross ◽

Victoria A. deMartelly ◽

Toni Ziegler ◽

...

Keyword(s):

Early Life ◽

World Monkey ◽

Common Marmoset ◽

Developmental Programming ◽

Intrauterine Environment ◽

Future Directions ◽

Marmoset Monkey ◽

Health And Disease ◽

The Common

Animal models have been critical in building evidence that the prenatal experience and intrauterine environment are capable of exerting profound and permanent effects on metabolic health through developmental programming of obesity. However, despite physiological and evolutionary similarities, nonhuman primate models are relatively rare. The common marmoset monkey ( Callithrix jacchus) is a New World monkey that has been used as a biomedical model for well more than 50 years and has recently been framed as an appropriate model for exploring early-life impacts on later health and disease. The spontaneous, multifactorial, and early-life development of obesity in the common marmoset make it a valuable research model for advancing our knowledge about the role of the prenatal and placental mechanisms involved in developmental programming of obesity. This paper provides a brief overview of obesity in the common marmoset, followed by a discussion of marmoset reproduction and placental characteristics. We then discuss the occurrence and utility of variable intrauterine environments in developmental programming in marmosets. Evidence of developmental programming of obesity will be given, and finally, we put forward future directions and innovations for including the placenta in developmental programming of obesity in the common marmoset.

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