Role of exposure to environmental chemicals in developmental origins of health and disease

2009 ◽  
pp. 82-97 ◽  
Author(s):  
Jerrold J. Heindel ◽  
Cindy Lawler
Keyword(s):  
Environmental Chemicals ◽  
Developmental Origins ◽  
Health And Disease

scholarly journals Homage to the ‘H’ in developmental origins of health and disease

2016 ◽  
Vol 8 (1) ◽  
pp. 8-29 ◽  
Author(s):  
C. S. Rosenfeld
Keyword(s):  
Female Offspring ◽  
Postnatal Period ◽  
Environmental Chemicals ◽  
Primary Concern ◽  
Developmental Origins ◽  
Adult Health ◽  
Fetal Origins ◽  
Adult Disease ◽  
Remediation Strategies ◽  
Health And Disease

Abundant evidence exists linking maternal and paternal environments from pericopconception through the postnatal period to later risk to offspring diseases. This concept was first articulated by the late Sir David Barker and as such coined the Barker Hypothesis. The term was then mutated to Fetal Origins of Adult Disease and finally broadened to developmental origins of adult health and disease (DOHaD) in recognition that the perinatal environment can shape both health and disease in resulting offspring. Developmental exposure to various factors, including stress, obesity, caloric-rich diets and environmental chemicals can lead to detrimental offspring health outcomes. However, less attention has been paid to date on measures that parents can take to promote the long-term health of their offspring. In essence, have we neglected to consider the ‘H’ in DOHaD? It is the ‘H’ component that should be of primary concern to expecting mothers and fathers and those seeking to have children. While it may not be possible to eliminate exposure to all pernicious factors, prevention/remediation strategies may tip the scale to health rather than disease. By understanding disruptive DOHaD mechanisms, it may also illuminate behavioral modifications that parents can adapt before fertilization and throughout the neonatal period to promote the lifelong health of their male and female offspring. Three possibilities will be explored in the current review: parental exercise, probiotic supplementation and breastfeeding in the case of mothers. The ‘H’ paradigm should be the focus going forward as a healthy start can indeed last a lifetime.

DOHaD research with populations in transition: a case study of prenatal diet remote recall with Yup’ik Alaskan women

2015 ◽  
Vol 6 (2) ◽  
pp. 79-87 ◽  
Author(s):  
C. Giordano ◽  
D. C. Benyshek
Keyword(s):  
Nutrition Transition ◽  
Developmental Pathways ◽  
Developmental Origins ◽  
Prenatal Nutrition ◽  
Mixed Methods Approach ◽  
Health And Disease ◽  
Specific Factors ◽  
Source Of Information

Maternal prenatal diet can exert a powerful influence on the health of children when they reach adulthood – an orienting phenomenon in the Developmental Origins of Health and Disease research paradigm. Similar to other subsistence-based communities experiencing a rapid nutrition transition, obesity is increasing among Yup’ik Alaskans. Diabetes prevalence, however, remains relatively low and may reflect developmental nutritional processes that have yet to be thoroughly considered. Here we investigate recall of Yup’ik women’s diets during a past pregnancy using a mixed-methods approach as a critical first step in exploring such alternative developmental hypotheses. For certain populations, retrospective dietary reports might be the only source of information on factors relevant to understanding developmental pathways to health and disease. Our analysis identified community-specific factors that will likely improve the accuracy of future retrospective dietary analyses investigating the role of prenatal nutrition in the developmental origins of metabolic disease, especially among Alaska Natives.

scholarly journals Metabolomics in the developmental origins of obesity and its cardiometabolic consequences

2015 ◽  
Vol 6 (2) ◽  
pp. 65-78 ◽  
Author(s):  
M. F. Hivert ◽  
W. Perng ◽  
S. M. Watkins ◽  
C. S. Newgard ◽  
L. C. Kenny ◽  
...  
Keyword(s):  
Life Course ◽  
Potential Role ◽  
Human Populations ◽  
Developmental Origins ◽  
Excess Adiposity ◽  
Health And Disease ◽  
The Life Course ◽  
Analytical Approaches ◽  
Review Current

In this review, we discuss the potential role of metabolomics to enhance understanding of obesity-related developmental origins of health and disease (DOHaD). We first provide an overview of common techniques and analytical approaches to help interested investigators dive into this relatively novel field. Next, we describe how metabolomics may capture exposures that are notoriously difficult to quantify, and help to further refine phenotypes associated with excess adiposity and related metabolic sequelae over the life course. Together, these data can ultimately help to elucidate mechanisms that underlie fetal metabolic programming. Finally, we review current gaps in knowledge and identify areas where the field of metabolomics is likely to provide insights into mechanisms linked to DOHaD in human populations.

scholarly journals Developmental Origins of Health and Disease: Integrating Environmental Influences

Endocrinology ◽  
2015 ◽  
Vol 156 (10) ◽  
pp. 3416-3421 ◽  
Author(s):  
Jerrold J. Heindel ◽  
John Balbus ◽  
Linda Birnbaum ◽  
Marie Noel Brune-Drisse ◽  
Philippe Grandjean ◽  
...  
Keyword(s):  
Health Program ◽  
Environmental Influences ◽  
Environmental Chemicals ◽  
Noncommunicable Diseases ◽  
Integrative Approach ◽  
Developmental Origins ◽  
Policy Interventions ◽  
Disease Occurrence ◽  
Animal Data ◽  
Health And Disease

Abstract There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned with understanding the pathophysiological basis for how environmental influences acting during early development influence the risk of later noncommunicable diseases. Similarly, there is no global research or public health program built around the DOHaD paradigm that encompasses all aspects of environment. To better inform the global health efforts aimed at addressing the growing epidemic of chronic noncommunicable diseases of environmental origin, we propose a two-pronged approach: first, to make it clear that the current concept of DOHaD comprehensively includes a range of environmental factors and their relevance to disease occurrence not just throughout the life span but potentially across several generations; and second, to initiate the discussion of how adoption of DOHaD can promote a more realistic, accurate, and integrative approach to understanding environmental disruption of developmental programming and better inform clinical and policy interventions. (Endocrinology 156: 3416–3421, 2015)

scholarly journals Developmental Origins of Adult Health and Disease: The Role of Periconceptional and Foetal Nutrition

2008 ◽  
Vol 102 (2) ◽  
pp. 82-89 ◽  
Author(s):  
I. Caroline McMillen ◽  
Severence M. MacLaughlin ◽  
Beverly S. Muhlhausler ◽  
Sheridan Gentili ◽  
Jaime L. Duffield ◽  
...  
Keyword(s):  
Developmental Origins ◽  
Adult Health ◽  
Health And Disease

scholarly journals Strategies to reduce non-communicable diseases in the offspring: negative and positive in utero programming

2018 ◽  
Vol 9 (6) ◽  
pp. 642-652 ◽  
Author(s):  
H. Rodriguez-Caro ◽  
S. A. Williams
Keyword(s):  
Economic Cost ◽  
In Utero ◽  
Communicable Diseases ◽  
Environmental Chemicals ◽  
Non Communicable Diseases ◽  
Promising Tool ◽  
Negative Role ◽  
Health And Disease ◽  
Unhealthy Diet

AbstractNon-communicable diseases (NCDs) are a major problem as they are the leading cause of death and represent a substantial economic cost. The ‘Developmental Origins of Health and Disease Hypothesis’ proposes that adverse stimuli at different life stages can increase the predisposition to these diseases. In fact, adverse in utero programming is a major origin of these diseases due to the high malleability of embryonic development. This review provides a comprehensive analysis of the scientific literature on in utero programming and NCDs highlighting potential medical strategies to prevent these diseases based upon this programming. We fully address the concept and mechanisms involved in this programming (anatomical disruptions, epigenetic modifications and microbiota alterations). We also examine the negative role of in utero programming on the increased predisposition of NCDs in the offspring, which introduces the passive medical approach that consists of avoiding adverse stimuli including an unhealthy diet and environmental chemicals. Finally, we extensively discuss active medical approaches that target the causes of NCDs and have the potential to significantly and rapidly reduce the incidence of NCDs. These approaches can be classified as direct in utero programming modifications and personalized lifestyle pregnancy programs; they could potentially provide transgenerational NCDs protection. Active strategies against NCDs constitute a promising tool for the reduction in NCDs.

scholarly journals The Role of the Microbiome in the Developmental Origins of Health and Disease

PEDIATRICS ◽  
2018 ◽  
Vol 141 (4) ◽  
pp. e20172437 ◽  
Author(s):  
Leah T. Stiemsma ◽  
Karin B. Michels
Keyword(s):  
Developmental Origins ◽  
Health And Disease

scholarly journals Population DNA methylation studies in the Developmental Origins of Health and Disease (DOHaD) framework

2018 ◽  
Vol 10 (3) ◽  
pp. 306-313 ◽  
Author(s):  
J. F. Felix ◽  
C. A. M. Cecil
Keyword(s):  
Dna Methylation ◽  
Health Outcomes ◽  
Early Life ◽  
Later Life ◽  
Epigenetic Mechanism ◽  
Future Research ◽  
Developmental Origins ◽  
Use Of Resources ◽  
Health And Disease

AbstractEpigenetic changes represent a potential mechanism underlying associations of early-life exposures and later life health outcomes. Population-based cohort studies starting in early life are an attractive framework to study the role of such changes. DNA methylation is the most studied epigenetic mechanism in population research. We discuss the application of DNA methylation in early-life population studies, some recent findings, key challenges and recommendations for future research. Studies into DNA methylation within the Developmental Origins of Health and Disease framework generally either explore associations between prenatal exposures and offspring DNA methylation or associations between offspring DNA methylation in early life and later health outcomes. Only a few studies to date have integrated prospective exposure, epigenetic and phenotypic data in order to explicitly test the role of DNA methylation as a potential biological mediator of environmental effects on health outcomes. Population epigenetics is an emerging field which has challenges in terms of methodology and interpretation of the data. Key challenges include tissue specificity, cell type adjustment, issues of power and comparability of findings, genetic influences, and exploring causality and functional consequences. Ongoing studies are working on addressing these issues. Large collaborative efforts of prospective cohorts are emerging, with clear benefits in terms of optimizing power and use of resources, and in advancing methodology. In the future, multidisciplinary approaches, within and beyond longitudinal birth and preconception cohorts will advance this complex, but highly promising, the field of research.

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