MUC1 Expression in Gastric Adenocarcinomas: Its Prognostic Significance and Clinicopathological Correlation

pS2, a 60-amino-acid chain peptide which is the most widespread estrogen-induced RNA messenger in MCF-7 breast cancer cells, is normally detected in the epithelium of gastric mucosa. The aims of this work were to evaluate the cytosolic pS2 content and its clinical significance in gastric carcinomas. Cytosolic pS2 levels were examined by immunoradiometric methods in 108 patients with primary gastric adenocarcinomas. The mean follow-up period was 23.3 months. The cytosolic pS2 levels of the tumors ranged widely, i.e., from 0.1 to 3217 ng/mg protein. There were no significant differences in pS2 content between tumors (mean ± standard error: 137.2±31.4 ng/mg protein) and paired adjacent mucosa samples (n=84; mean ± standard error: 249.6±32.6 ng/mg protein), nor were there any significant differences in tumoral pS2 levels with respect to clinicopathologic parameters such as patient age and sex or tumor location, stage, histologic type or grade. However, the results indicated that high intratumoral pS2 levels were significantly and independently associated with an unfavorable outcome in the overall group of patients (p=0.0266) and in patients with resectable gastric cancer (p=0.003). In conclusion, pS2 may represent a useful biological marker in gastric cancer.

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Clinicopathological Correlation and Prognostic Significance of Protein Kinase Cα Overexpression in Human Gastric Carcinoma

PLoS ONE ◽

10.1371/journal.pone.0056675 ◽

2013 ◽

Vol 8 (2) ◽

pp. e56675 ◽

Cited By ~ 5

Author(s):

Shee-Chan Lin ◽

Wei-Yu Chen ◽

Kai-Yuan Lin ◽

Sheng-Hsuan Chen ◽

Chun-Chao Chang ◽

...

Keyword(s):

Protein Kinase ◽

Gastric Carcinoma ◽

Prognostic Significance ◽

Clinicopathological Correlation ◽

Human Gastric Carcinoma ◽

Protein Kinase Cα

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Classifying Lupus Nephritis: An Ongoing Story

The Scientific World JOURNAL ◽

10.1155/2014/580620 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 10

Author(s):

Saba Kiremitci ◽

Arzu Ensari

Keyword(s):

Lupus Nephritis ◽

Prognostic Significance ◽

World Health ◽

Clinicopathological Correlation ◽

New Classification ◽

Tubulointerstitial Lesions ◽

The World ◽

Weak Points ◽

Health Organization

The role of the renal biopsy in lupus nephritis is to provide the diagnosis and to define the parameters of prognostic and therapeutic significance for an effective clinicopathological correlation. Various classification schemas initiated by World Health Organization in 1974 have been proposed until the most recent update by International Society of Nephrology/Renal Pathology Society in 2004. In this paper, we reviewed the new classification system with the associated literature to highlight the benefits and the weak points that emerged so far. The great advantage of the classification emerged to provide a uniform reporting for lupus nephritis all over the world. It has provided more reproducible results from different centers. However, the studies indicated that the presence of glomerular necrotizing lesion was no longer significant to determine the classes of lupus nephritis leading to loss of pathogenetic diversity of the classes. Another weakness of the classification that also emerged in time was the lack of discussions related to the prognostic significance of tubulointerstitial involvement which was not included in the classification. Therefore, the pathogenetic diversity of the classification still needs to be clarified by additional studies, and it needs to be improved by the inclusion of the tubulointerstitial lesions related to prognosis.

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