The Prognostic Significance of c-MET and EGFR Overexpression in Resected Gastric Adenocarcinomas

pS2, a 60-amino-acid chain peptide which is the most widespread estrogen-induced RNA messenger in MCF-7 breast cancer cells, is normally detected in the epithelium of gastric mucosa. The aims of this work were to evaluate the cytosolic pS2 content and its clinical significance in gastric carcinomas. Cytosolic pS2 levels were examined by immunoradiometric methods in 108 patients with primary gastric adenocarcinomas. The mean follow-up period was 23.3 months. The cytosolic pS2 levels of the tumors ranged widely, i.e., from 0.1 to 3217 ng/mg protein. There were no significant differences in pS2 content between tumors (mean ± standard error: 137.2±31.4 ng/mg protein) and paired adjacent mucosa samples (n=84; mean ± standard error: 249.6±32.6 ng/mg protein), nor were there any significant differences in tumoral pS2 levels with respect to clinicopathologic parameters such as patient age and sex or tumor location, stage, histologic type or grade. However, the results indicated that high intratumoral pS2 levels were significantly and independently associated with an unfavorable outcome in the overall group of patients (p=0.0266) and in patients with resectable gastric cancer (p=0.003). In conclusion, pS2 may represent a useful biological marker in gastric cancer.

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Does clear cell carcinoma of stomach exist? Clinicopathological and prognostic significance of clear cell changes in gastric adenocarcinomas

Histopathology ◽

10.1111/his.12372 ◽

2014 ◽

Vol 65 (1) ◽

pp. 90-99 ◽

Cited By ~ 2

Author(s):

Joo-Yeon Kim ◽

Do Youn Park ◽

Gwang Ha Kim ◽

Tae-Yong Jeon ◽

Gregory Y Lauwers

Keyword(s):

Cell Carcinoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Prognostic Significance ◽

Gastric Adenocarcinomas ◽

Cell Changes

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Prognostic significance of PAK4 expression in gastric cancer

Journal of Clinical Pathology ◽

10.1136/jclinpath-2015-203330 ◽

2015 ◽

Vol 69 (7) ◽

pp. 580-585 ◽

Cited By ~ 11

Author(s):

Kenta Kobayashi ◽

Mikito Inokuchi ◽

Yoko Takagi ◽

Sho Otsuki ◽

Yoshitaka Fujimori ◽

...

Keyword(s):

Gastric Cancer ◽

Prognostic Factor ◽

Tumour Progression ◽

Prognostic Significance ◽

Multivariable Analysis ◽

Independent Prognostic Factor ◽

Depth Of Invasion ◽

Gastric Adenocarcinomas ◽

Growth Factor Signalling ◽

Clinicopathological Variables

Aimsp-21 activated kinase (PAK) 4, part of the six PAK families, plays an important role in growth factor signalling, cytoskeletal remodelling, gene transcription, cell proliferation and oncogenic transformation. However, the clinical significance of PAK4 in gastric cancer has yet to be fully elucidated. PAK4 expression was evaluated, and the correlations of PAK4 expression with clinicopathological features and outcomes in gastric cancer were examined.MethodsGastric adenocarcinomas obtained from 217 patients who underwent gastrectomy were analysed. PAK4 expression was evaluated using immunohistochemical staining.ResultsPAK4 overexpression was found in 95 (43.8%) of 217 tumours . High PAK4 expression was significantly correlated with clinicopathological variables related to tumour progression, including depth of invasion, metastatic lymph nodes, pathological stage, distant metastasis or recurrent disease. High PAK4 expression was significantly associated with poorer disease-specific survival (DSS) (p<0.001) and relapse-free survival (RFS) (p<0.001). On multivariable analysis, PAK4 was an independent prognostic factor for DSS (HR 2.5 (95% CI 1.4 to 4.7), p=0.003) and RFS (HR 2.8 (95% CI 1.4 to 5.6), p=0.004). Even in stage II and III disease, PAK4 was an independent prognostic factor for RFS (HR 2.2 (95% CI 1.1 to 4.5), p=0.029).ConclusionsPAK4 may become a new prognostic factor in patients with gastric cancer.

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The Prognostic Significance of c-Met and p53 Immunohistochemical Expression in Gastric and Colorectal Carcinomas

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.5910 ◽

2021 ◽

Vol 9 (A) ◽

pp. 134-142

Author(s):

Amany A. Abou-Bakr ◽

Alshaymaa A. Abdelaziz ◽

Ibrahim A. Malash ◽

Osman Mansour ◽

Ibrahim M. Abdelsalam ◽

...

Keyword(s):

Median Overall Survival ◽

Potential Role ◽

Prognostic Significance ◽

Tumor Stage ◽

Colorectal Adenomas ◽

Colorectal Carcinomas ◽

Immunohistochemical Expression ◽

P53 Expression ◽

Gastric Carcinomas ◽

Gastric Adenocarcinomas

BACKGROUND: Colorectal and gastric carcinomas are the most common and deadly gastrointestinal (GIT) malignancies. AIM: This study aimed to evaluate the expression of c-Met and p53 in gastric and colorectal carcinomas (CRCs) as well as colorectal adenomas using immunohistochemistry. MATERIALS AND METHODS: c-Met and p53 immunohistochemical expression was conducted on 66 cases of gastric adenocarcinomas and total of 60 colonic cases (36 CRCs and 24 colorectal adenomas). RESULTS: In this study, c-Met was positively expressed in 54.5% of gastric carcinomas and 50% of CRCs. In addition, p53 was positively expressed in 56.1% of gastric carcinomas and 72.2% of CRCs. Moreover, higher expression of both c-Met (p = 0.001) and p53 expression (p < 0.001) was reported in CRCs compared to colorectal adenomas. In the same context, c-Met and p53 expressions were positively correlated with intestinal type gastric adenocarcinoma (p < 0.001 and p = 0.03, respectively). Moreover, c-Met was correlated with non-mucinous adenocarcinomas (p = 0.008) and lower grades (p < 0.001) of gastric carcinomas. As regard survival analysis in gastric carcinomas, median overall survival (OS) was better in p53 positive patients (p = 0.05), patients with negative lymph node metastasis (p = 0.03), and patients with better response to neoadjuvant chemotherapy (p = 0.04). In contrast, c-Met did not exhibit significant correlation with OS (p > 0.05). Both c-Met and p53 did not reveal significant correlation with tumor stage and site in both CRCs and gastric carcinomas (p > 0.05). CONCLUSION: We concluded that c-Met and p53 are expressed in the most common GIT malignancies addressing them as potential biomarkers. In addition, c- Met and p53 may have a potential role in colorectal cancer development as they showed higher positivity in CRCs compared to adenomas.

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Prognostic Significance of Serum and Tissue Carcinoembryonic Antigen in Patients with Gastric Adenocarcinomas

Cancer Research and Treatment ◽

10.4143/crt.2008.40.1.16 ◽

2008 ◽

Vol 40 (1) ◽

pp. 16 ◽

Cited By ~ 16

Author(s):

Seong-Hoon Park ◽

Ki-Beom Ku ◽

Ho-Young Chung ◽

Wansik Yu

Keyword(s):

Carcinoembryonic Antigen ◽

Prognostic Significance ◽

Gastric Adenocarcinomas

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Ultrastructural features of prognostic significance in human oral cancer

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100123490 ◽

1992 ◽

Vol 50 (1) ◽

pp. 618-619

Author(s):

Karvita B. Ahluwalia ◽

Nidhi Sharma

Keyword(s):

Oral Cancer ◽

Squamous Cell ◽

Common Knowledge ◽

Prognostic Significance ◽

Growth Control ◽

Terminal Differentiation ◽

Squamous Cell Carcinomas ◽

Effective Therapy ◽

Invasive Potential ◽

Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

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