Maternal serum vitamin D and spontaneous preterm birth

AimsTo analyse the factors associated with myopia in school-aged children with preterm birth and with or without retinopathy of prematurity (ROP).MethodsChildren born prematurely between January 2010 and December 2011 were enrolled in this cross-sectional study when they reached school age between April 2017 and June 2018 in a referral centre. The main parameters were cycloplegic refraction, time spent outdoors and serum 25-hydroxyvitamin D (25(OH)D) concentration.ResultsA total of 99 eyes from 99 children with a mean age of 6.8 years underwent analysis. The average time spent outdoors was significantly higher in the non-myopic group (0.9 ± 0.5 hours/day) than in the myopic group (0.7 ± 0.3 hours/day) (p = 0.032). After adjustment for age, sex, number of myopic parents, ROP severity, near-work time and serum 25(OH)D concentration, more time spent outdoors was correlated with a lower odds of myopia (OR, 0.13 per additional hour per day; 95% CI, 0.02–0.98; p = 0.048). Mean serum 25(OH)D concentrations were similar between the myopic and non-myopic groups (49.7 ± 13.6 and 48.8 ± 14.0 nmol/mL; p = 0.806) and were not correlated with spherical equivalence power (r = −0.09; p = 0.418). Vitamin D insufficiency was present in 57% of the participants.ConclusionsAmong preterm children with or without ROP, more time spent outdoors was associated with lower odds of myopia. The serum 25(OH)D concentration was not associated with myopia, but a high proportion of the participants had insufficient levels.

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Maternal Serum 25-Hydroxy Vitamin D Concentrations and Calcium Levels in Preeclamptic Women, Sindh, Pakistan

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i52b33619 ◽

2021 ◽

pp. 216-221

Author(s):

Khalil Ahmed Memon ◽

Hazoora Shaikh ◽

Rukhsana Soomoro ◽

Yasmeen Joyo ◽

Saira Parveen ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Multinomial Logistic Regression ◽

Serum Vitamin ◽

Maternal Serum ◽

Control Group ◽

Case Group ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

25 Hydroxyvitamin D

Objectives: To analyse the levels of serum 25-hydroxyvitamin D 25(OH) Dand calcium concentrations in patients with pre-eclampsia, Hyderabad, Sindh, Pakistan. Methodology: Cross sectional study was conducted at the Gynaecology and Obstetrics Department, LUHS, Hyderabad during the period of January 2020 to June 2020. Total 150 pregnant women were selected according to predesign Proforma and divided into two groups. 50 females were normal normotensive pregnant women as a control group, 100 were pre-eclamptic patients as case group. Obstetric history, clinical data was gathered and then 5ml of blood sample was collected from each patient. The blood samples were taken for the analysis of 25-hydroxyvitamin D or 25(OH)D and calcium levels. 25(OH)D were performed on chemiluminescence, While calcium concentration of Microlab 300. Data was analysed by using SPSS version 23. Student t-test was used for analysed of continuous variables. Results: The maternal serum vitamin D and calcium levels were significantly decreased as compared to patient with preeclampsia and normotensive healthy pregnant ladies. The blood pressure also declined in case group with P<0.001.Multinomial logistic regression showed significant odd ratio of Vitamin-D and Calcium deficiency in preeclampsia. Conclusion: The present study reveals that 25-hydroxyvitamin D, and Calcium levels declined significantly in preeclamptic women, and mighty be biomarker of this life threating disease.

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Association of maternal serum vitamin D level with preeclampsia or eclampsia and its relationship with neonatal outcome and neonatal serum calcium level

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20175285 ◽

2017 ◽

Vol 6 (12) ◽

pp. 5580 ◽

Cited By ~ 1

Author(s):

Mahija Sahu ◽

Sonali Tripathy ◽

Pallavi Bhuyan

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Calcium ◽

Calcium Level ◽

Neonatal Outcome ◽

Serum Vitamin ◽

Maternal Serum ◽

Third Trimester ◽

Serum Vitamin D ◽

Pregnant Females

Background: Vitamin D deficiency has been associated with various poor maternal and fetal outcome and is proposed to be important in the pathogenesis of preeclampsia. The aim of the study was to evaluate the serum vitamin-D levels in normal pregnant females and pre-eclampsia or eclampsia individuals in the third trimester admitted for termination or in labour and to assess the neonatal outcome and neonatal serum calcium levels of babies born to mother in both the groups.Methods: This study was a prospective comparative study carried out on the pregnant women in the third trimester admitted for termination or in labour. 100 pregnant females with either pre-eclampsia or eclampsia were compared with equal number of normotensive pregnant females for serum vitamin D. They were followed up until delivery and subsequently neonatal serum calcium level was estimated.Results: Most pregnant females had vitamin D deficiency pointing towards universal prevalence. Only 10% had suboptimal to optimal vitamin D level while 90% had vitamin deficiency. The hypertensive group had lower mean serum vitamin D level (9.06±5.20 ng/ml) as compared to normotensive group (13.67±7.24 ng/ml). Neonatal outcome was poorer in the hypertensive group. Neonates born to hypertensive mothers had lower mean calcium level (8.30±1.46mg/dl) when compared to those born to normotensive mothers (8.82±0.918mg/dl).Conclusion: The study findings revealed that there lies a consistent association of maternal serum vitamin D deficiency with the hypertensive disorders of pregnancy and neonatal morbidity.

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Vitamin D Levels in Pregnant Congolese Women and Their New-Borns, and the Association with Neonatal Outcomes – A Pilot Study

10.21203/rs.3.rs-40821/v1 ◽

2020 ◽

Author(s):

Gurpreet Dhillon ◽

Sunil Rai ◽

Harpreet Dhillon ◽

Shibu Sasidharan ◽

Costa Kimweri ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Preterm Births ◽

Maternal Serum ◽

Neonatal Outcomes ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Sufficient Vitamin

Abstract Background: This study was thus undertaken to study the estimation of vitamin D levels in pregnant women and their newborns in DRC and to study its association with various neonatal outcomes. Methods: Observational study done on 569 pregnant women and their newborn babies. Sample obtained from maternal serum and cord blood from the placental end during peripartum period. The data was analysed to estimate the prevalence of vitamin D levels in mothers and newborns and to identify association, if any, between maternal vitamin D levels and neonatal outcomes.Results: 464 mothers had sufficient vitamin D (VDS) levels (>30 ng/dL) and 105 had vitamin D deficiency (VDD) with mean maternal serum vitamin D level of 35.63ng/ml (SD 6.18, range 9.2-39.8). All the newborns (n=569) were vitamin D deficient (<30ng/ml). The percentage of LBW babies born to VDD mothers was 18.09%, which was very similar to the percentage of LBW babies born to VDS mothers (18.31%) (p=0.76456749). The incidence of caesarean section was 58.09% in the vitamin D deficient (VDD) group as compared to 19.61% in the sufficient (VDS) group (p<0.0005). The incidence of preterm births was 10.77% in the sufficient group (VDS) as compared to 17.14% in the vitamin D deficient (VDD) group (p=0.038). Conclusion: Our findings will help health professionals, policy makers, and the general public in Africa aware of the high prevalence of vitamin D deficiency and the associated health risks.

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ASSOCIATION BETWEEN MATERNAL SERUM VITAMIN D AND EARLY PREGNANCY SPONTANEOUS ABORTION IN IRAQI WOMEN

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i2.24588 ◽

2018 ◽

Vol 11 (2) ◽

pp. 432

Author(s):

Ashwaq Kadhim Mohammed ◽

Vian Hussam Almansi Alqani

Keyword(s):

Vitamin D ◽

Spontaneous Abortion ◽

Early Pregnancy ◽

Pregnancy Loss ◽

Strong Predictor ◽

Serum Vitamin ◽

Maternal Serum ◽

Childbearing Age ◽

Serum Vitamin D ◽

History Of

Objective: This study was aimed to estimate the Vitamin D serum concentration in a cohort of women with a history of recurrent spontaneous abortion.Methods: The current cross-sectional study was conducted at Al-Diwaniya maternity and child teaching hospital, Al-Diwaniya province, Iraq. Data collection, lab work, and procedures related to the study extended from August 2016 to August 2017. The study enrolled 42 women of childbearing age who have a history of spontaneous early pregnancy loss. From each woman, a venous sample was obtained and sent to a lab to assess serum Vitamin D concentrations using standard routine biochemical methods.Results: Assessment of mean maternal serum Vitamin D concentration revealed that the mean was 21.48±11.82 (ng/ml) and the range was from 5 to 50 (ng/ml). The number of women with low serum Vitamin D (<20 ng/ml) was 25 (approximately 60%), the results also revealed a highly negative correlation was obtained between number of abortions and maternal serum Vitamin D (r=−0.717, p<0.001) and that the value or R2 was 0.514 which indicated that the level of Vitamin D alone can act as an independent predictor to explain 51.4% of spontaneous abortions in the participating women.Conclusion: Vitamin D level is a strong predictor of pregnancy loss in early pregnancy, and that correction of Vitamin D status among Iraqi pregnant ladies may substantially reduce the frequency of spontaneous abortion.

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Maternal Serum Vitamin D levels During Pregnancy and Offspring Neurocognitive Development

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/j.yobg.2012.06.011 ◽

2012 ◽

Vol 2012 ◽

pp. 202-204

Author(s):

L.P. Shulman

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Maternal Serum ◽

Neurocognitive Development ◽

Serum Vitamin D ◽

Vitamin D Levels

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