scholarly journals A Topographical Map of the Causal Network of Mechanisms Underlying the Relationship Between Major Depressive Disorder and Coronary Heart Disease

2011 ◽  
Vol 45 (5) ◽  
pp. 351-369 ◽  
Author(s):  
Nicolas J. C. Stapelberg ◽  
David L. Neumann ◽  
David H. K. Shum ◽  
Harry McConnell ◽  
Ian Hamilton-Craig
Author(s):  
Petra Hoen ◽  
Peter de Jonge ◽  
Beeya Na ◽  
Ramin Farzaneh-Far ◽  
Elissa Epel ◽  
...  

Background Shortened telomere length has been associated with mortality in patients with coronary heart disease (CHD) and is considered an emerging marker of biological age. Whether short telomere length is associated with depression in patients with CHD has not been evaluated. Methods In a cross-sectional study of 952 outpatients with stable CHD, we ascertained the presence of major depressive disorder using the Computerized Diagnostic Interview Schedule. Relative mean telomere length was measured from leukocyte DNA using a quantitative polymerase chain reaction assay. We examined the association between depression and leukocyte telomere length using linear and logistic regression models. Results Of the 952 participants, 206 (22%) had current (past month) depression. Patients with depression had lower mean ± SE telomere length than those without depression ( Table ). Likewise, patients with MDD had a 70% greater odds of having telomere length in the lowest vs. highest quartile (adjusted OR 1.70. 95% CI, 1.05-2.76; p=0.03). Conclusion Major depressive disorder is associated with reduced leukocyte telomere length in patients with stable CHD. The potential mechanisms underlying this association deserve further study. Mean +/- SE telomere length by presence of major depressive disorder Adjusted for Current major depression N=206 No current major depression N=746 P value age, sex 0.86±0.02 0.90±0.1 .02 age, sex, diabetes, BMI, smoking 0.86±0.02 0.89±0.01 .04 age, sex, diabetes, BMI, smoking, LVEF, statin use 0.85±0.02 0.89±0.01 .03


2021 ◽  
Author(s):  
Serena O’Brien

Background: Prior to the housing crisis in 2008, research had seldom been conducted on the effects of housing foreclosures on health outcomes. Even though national housing markets have somewhat recovered from the 2008 recession, mortgage loan borrowers across the U.S. remain adversely impacted by the foreclosure crisis. Objectives: The purpose of this research is to evaluate the relationship between foreclosure rates and mental and physical health outcomes, at the U.S. state-level, over a period of seventeen years (2000-2016). This study expects that all the seven health variables in question will share a significant positive relationship with foreclosure. Methods: In this study (N=816), panel regression analysis, using a fixed effects model, is used to analyze the relationship between the two economic variables and seven health variables in question. Results: A significant positive relationship exists between foreclosure and the following health outcomes: major depressive disorder (0.35*** p < 0.001, CI = 0.26 — 0.43), nutritional deficiencies (3.80*** p < 0.001, CI = 3.04 — 4.57), and self-harm and interpersonal violence (0.71*** p < 0.001, CI = 0.55 — 0.86). The health outcomes shown to share a statistically significant negative correlation between foreclosure include: anxiety disorders (0.52*** p < 0.001, CI = -0.60 — -0.44), alcohol use disorders (0.41*** p < 0.001, CI = -0.57 — -0.25), and drug use disorders (0.24*** P = 0.001, CI = -0.39 — -0.10). No significant relationship was elucidated between foreclosure and hypertensive heart disease. Conclusion: Although significant relationships were uncovered between foreclosure and rates of major depressive disorder, nutritional deficiencies, and self-harm and interpersonal violence, more research is required to further evaluate the relationship between economic outcomes and health outcomes. Specifically, more research is necessary to unveil the relationships between foreclosure and the health outcomes: anxiety disorders, drug use disorders, alcohol use disorders, and hypertensive heart disease. Keywords: foreclosure, health, unemployment, major depressive disorder, anxiety disorder, nutritional deficiencies, self-harm and interpersonal violence, drug use disorder, alcohol use disorder, hypertensive heart disease


2021 ◽  
Author(s):  
Serena O’Brien

Background: Prior to the housing crisis in 2008, research had seldom been conducted on the effects of housing foreclosures on health outcomes. Even though national housing markets have somewhat recovered from the 2008 recession, mortgage loan borrowers across the U.S. remain adversely impacted by the foreclosure crisis. Objectives: The purpose of this research is to evaluate the relationship between foreclosure rates and mental and physical health outcomes, at the U.S. state-level, over a period of seventeen years (2000-2016). This study expects that all the seven health variables in question will share a significant positive relationship with foreclosure. Methods: In this study (N=816), panel regression analysis, using a fixed effects model, is used to analyze the relationship between the two economic variables and seven health variables in question. Results: A significant positive relationship exists between foreclosure and the following health outcomes: major depressive disorder (0.35*** p < 0.001, CI = 0.26 — 0.43), nutritional deficiencies (3.80*** p < 0.001, CI = 3.04 — 4.57), and self-harm and interpersonal violence (0.71*** p < 0.001, CI = 0.55 — 0.86). The health outcomes shown to share a statistically significant negative correlation between foreclosure include: anxiety disorders (0.52*** p < 0.001, CI = -0.60 — -0.44), alcohol use disorders (0.41*** p < 0.001, CI = -0.57 — -0.25), and drug use disorders (0.24*** P = 0.001, CI = -0.39 — -0.10). No significant relationship was elucidated between foreclosure and hypertensive heart disease. Conclusion: Although significant relationships were uncovered between foreclosure and rates of major depressive disorder, nutritional deficiencies, and self-harm and interpersonal violence, more research is required to further evaluate the relationship between economic outcomes and health outcomes. Specifically, more research is necessary to unveil the relationships between foreclosure and the health outcomes: anxiety disorders, drug use disorders, alcohol use disorders, and hypertensive heart disease. Keywords: foreclosure, health, unemployment, major depressive disorder, anxiety disorder, nutritional deficiencies, self-harm and interpersonal violence, drug use disorder, alcohol use disorder, hypertensive heart disease


2006 ◽  
Vol 47 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Mark W. Ketterer ◽  
Lawson Wulsin ◽  
J. Jane Cao ◽  
John Schairer ◽  
Arif Hakim ◽  
...  

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