A Study of Aetiological Factors at Critical Periods of Development in Autistic Children

1973 ◽  
Vol 7 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Sara Williams ◽  
Juliet Harper

Ninety-seven children were diagnosed as suffering from infantile autism according to the nine points of the British Working Party and the World Health Organization classification of Mental Disorders in Childhood. Data on these cases were analyzed in terms of aetiology as known, social class of parents, year of onset, its relationship to the presence of an organic cerebral defect, and outcome in terms of the present educational placement of the child. Findings suggested that infantile autism was a disorder with a multiple aetiology and the causes, both organic and environmental, were interrelated. It was postulated that the most consistent effect present in the early backgrounds of these children was a history of sensory deprivation at a critical period of development.

Hematology ◽  
2009 ◽  
Vol 2009 (1) ◽  
pp. 645-655 ◽  
Author(s):  
David P. Steensma

AbstractWhat is the most sensible way of organizing the disorderly spectrum of acquired marrow failure states collectively known as the myelodysplastic syndromes (MDS)? While the 2008 version of the World Health Organization classification is the current standard, the recent proliferation of MDS prognostic tools illustrates the usefulness of supplemental information for clinical purposes. Many cases of acquired bone marrow failure do not fit cleanly into established MDS categories, yet an alternative diagnosis is not apparent. The term “idiopathic cytopenias of undetermined significance” (ICUS) has been proposed to describe these cases, but there is a paucity of information about the natural history of ICUS. New data on the natural history of MDS associated with a broad range of cytogenetic abnormalities that were not included in the International Prognostic Scoring System (IPSS), as well as the emerging picture of karyotypically occult DNA changes, promise to inform future classifications.


2001 ◽  
Vol 18 (6) ◽  
pp. 1059-1068 ◽  
Author(s):  
E. Brambilla ◽  
W.D. Travis ◽  
T.V. Colby ◽  
B. Corrin ◽  
Y. Shimosato

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Harshima Disvini Wijesinghe ◽  
Ajith Malalasekera

Giant cell urothelial carcinoma is a rare variant of bladder cancer recognized by the current World Health Organization classification of urologic tumours. It is an aggressive tumour with a poor prognosis that usually presents at an advanced stage. It is characterized histologically by pleomorphic giant cells. We discuss a case of giant cell urothelial carcinoma presenting at an early stage in a previously well 62-year-old woman. Histology showed a tumour comprising pancytokeratin positive bizarre mononuclear and multi-nuclear giant cells admixed with areas of conventional urothelial carcinoma and carcinoma in situ. Three-month follow-up cystoscopy and magnetic resonance imaging showed no evidence of recurrence or pelvic lymphadenopathy.


2006 ◽  
Vol 130 (8) ◽  
pp. 1233-1235
Author(s):  
Stephen Berns ◽  
Gary Pearl

Abstract Pineal anlage tumor is an extremely rare tumor that is not listed in the 2000 World Health Organization Classification of nervous system tumors. It has been defined as a primary pineal tumor with both neuroepithelial and ectomesenchymal differentiation and without endodermal differentiation. We review the literature on this tumor, including the clinical presentation, gross pathology, histopathology, immunohistochemistry, differential diagnosis, and prognosis.


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