Determination of Protein-Bound Radioactive Iodine

1958 ◽  
Vol 10 (2) ◽  
pp. 211-215 ◽  
Author(s):  
L. Korsgaard Christensen
Keyword(s):  
Radioactive Iodine

scholarly journals Ion chromatographic analysis of aqueous iodine species by conductivity and radioactivity measurements

2005 ◽  
Vol 93 (9-10) ◽  
Author(s):  
Dorothea Schumann ◽  
R. Grasser ◽  
R. Dressler ◽  
H. Bruchertseifer
Keyword(s):  
Chromatographic Analysis ◽  
Nuclear Power ◽  
Power Plants ◽  
Radioactive Iodine ◽  
Cooling Water ◽  
Molecular Iodine ◽  
New Device ◽  
Iodine Species ◽  
Radioactivity Measurements

SummaryA new device was developed for the identification of several iodine species in aqueous solution using ion chromatography. Iodide, iodate and molecular iodine can be determined. (The equipment allows both conductivity and radioactivity detections.) The method is applicable for the determination of radioactive iodine contaminations in the cooling water of nuclear power plants.

Isolation of radioactive iodothyronines for kinetic studies: a comparison of two methods

1982 ◽  
Vol 99 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Jens Faber ◽  
lb Bo Lumholtz ◽  
Carsten Kirkegaard ◽  
Kaj Siersbæk-Nielsen ◽  
Thorkild Friis
Keyword(s):  
Radioactive Iodine ◽  
Single Injection ◽  
Kinetic Studies ◽  
Acid Precipitation ◽  
Relative Difference ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Minor Degree ◽  
A Minor

Abstract. A method based on the principle of gel separation followed by antibody extraction (GSAE) has been developed for isolation of radioactive thyroxine (T4), 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3), 3,3'-diiodothyronine (3,3'-T2), 3',5'-diiodothyronine (3',5'-T2) and 3'-monoiodothyronine (3'-T1) in serum. This method was used for the estimation of the metabolic clearance rate (MCR) of the iodothyronines using the single injection, non-compartmental approach, and was compared to the conventional trichloroacetic acid precipitation/ethanol extraction (TCA-E) technique. The GSAE method excluded the co-determination of radioactive iodine and iodoproteins, whereas the co-determination of radiolabelled daughter iodothyronines was found negligible. The relative difference of duplicate estimations of MCR was approximately 10%. Using the TCA-E method for isolation of tracer, the MCR of T4, T3 and rT3 was underestimated to a minor degree (20%), whereas the MCRs of 3,3'-T2, 3',5'-T2 and 3'-T1 were 20–40% of those estimated by the GSAE method. In conclusion the GSAE method was found suitable for kinetic studies of iodothyronines, whereas the TCA-E method cannot be used for turnover studies of 3,3'-T2, 3',5'-T2 or 3'-T1.

Factitious thyrotoxicosis: how to find it

Diagnosis ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. 141-145
Author(s):  
Pakaworn Vorasart ◽  
Chutintorn Sriphrapradang
Keyword(s):  
Radioactive Iodine ◽  
Graves Disease ◽  
Case Presentation ◽  
Thyroglobulin Antibodies ◽  
Definitive Therapy ◽  
Thyroid Uptake ◽  
Thyroid Hormone Levels ◽  
Difficult Challenge

AbstractBackgroundAlthough the most common cause of thyrotoxicosis is Graves’ disease, the determination of the cause of thyrotoxicosis is important for establishing appropriate management. Diagnosis of surreptitious ingestion of thyroid hormones or factitious thyrotoxicosis often presents a difficult challenge especially in a patient with previously diagnosed Graves’ disease. The objective of this report was to demonstrate various approaches to support the diagnosis of factitious thyrotoxicosis.Case presentationWe describe a patient with underlying Graves’ disease who underwent definitive therapy and needed long-term levothyroxine (LT4) replacement therapy. Later she developed thyrotoxicosis. Although factitious thyrotoxicosis was suspected because of very low thyroid uptake and low thyroglobulin (Tg) levels with the absence of thyroglobulin antibodies (TgAbs), she still refused any medication or substance use. After the administration of bile acid sequestrant, the thyroid hormone levels rapidly returned to normal within 1 month.ConclusionsThe diagnosis of factitious thyrotoxicosis is based upon the absence of goiter, suppressed serum Tg level, decreased radioactive iodine (RAI) uptake, and excellent response after cholestyramine treatment.

The Determination of Radioactive Iodine in Biologic Material.

1950 ◽  
Vol 75 (2) ◽  
pp. 390-392 ◽  
Author(s):  
J. E. Rall ◽  
H. W. Johnson ◽  
M. H. Power ◽  
A. Albert
Keyword(s):  
Radioactive Iodine

Development of a non-radioactive iodine label-based method for the determination of proteolytic activity

The Analyst ◽  
1991 ◽  
Vol 116 (2) ◽  
pp. 165 ◽  
Author(s):  
Paula Keating ◽  
Fiona Anderson ◽  
Garret Donnelly ◽  
Richard O'Kennedy
Keyword(s):  
Proteolytic Activity ◽  
Radioactive Iodine

Determination of Radioactive Iodine in Water and Sewage

1958 ◽  
Vol 50 (11) ◽  
pp. 1499-1504 ◽  
Author(s):  
Richard B. Hahn ◽  
Samuel Levin ◽  
Robert L. Friedlander
Keyword(s):  
Radioactive Iodine

From the history of treatment of thyrotoxicosis with radioactive iodine in Russia

2019 ◽  
Vol 44 (2) ◽  
pp. 54-54
Author(s):  
V. V. Fadeev ◽  
N. D. Petrova
Keyword(s):  
Body Weight ◽  
Clinical Practice ◽  
Thyroid Gland ◽  
Connective Tissue ◽  
Radioactive Iodine ◽  
Complete Replacement ◽  
Domestic Literature ◽  
Complete Destruction ◽  
History Of

The quantitative determination of the content of radioactive iodine in the urine for the evaluation of the functional state of the thyroid gland was first introduced into clinical practice by J. Hamilton in 1939, and in 1942 he developed a method for determining the content of radioactive iodine directly in the thyroid gland, and in the same year reported experiment on a dog who was injected with a large dose (300 μCi per 1 g of body weight) of radioactive 1311, which caused complete destruction of the thyroid gland with complete replacement of its structure with connective tissue with complete safety araschitovidnyh glands. By 1950, there were already many works devoted to this topic. In the mid-50s, such works began to appear in Russia. Among them, one can note the research of M. N. Fateeva (1953), V. K. Modestov (1958), A. 3. Tsfasman (1961), P. I. Egorov (1961), N M. Draznina (1961) and others, but this problem is most fully reflected in the domestic literature in the writings of prof. V. G. Spesivtseva [1-3].

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