A rare case of ovarian carcinosarcoma successfully treated with the neoadjuvant chemotherapy of paclitaxel and ifosfamide

Introduction. Small cell neuroendocrine carcinomas of the urinary tract is an extremely rare entity and very few cases have been reported in the literature. Small cell neuroendocrine carcinoma of the urinary tract (SCC-UT) is the association between bladder and urinary upper tract-small cell carcinoma (UUT-SCC). It characterized by an aggressive clinical course. The prognosis is poor due to local or distant metastases, and usually the muscle of the bladder is invaded.Case Presentation. We report a rare case of a 54-year-old Arab male native of moroccan; he is a smoker and was referred to our institution for intermittent hematuria. Following a diagnosis of small cell neuroendocrine carcinomas of the ureter and the bladder, thoracoabdominal-pelvic CT was done, and the staging of the tumor was done in the bladder (T2N0M0) and (T1N0M0) in the ureter. Neoadjuvant alternating doublet chemotherapy with ifosfamide/doxorubicin and etoposide/cisplatin was realized, and nephroureterectomy associated to a cystoprostatectomy was carried out. After 24 months of followup, no local or distant metastasis was detected.Conclusion. The purpose of this review is to present a rare case of pure small cell neuroendocrine carcinoma of the urinary tract and review the literature about the place of neoadjuvant chemotherapy in this rare tumors.

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Chondroblastic Osteosarcoma of the Mandible in a Patient on Risedronate: A Rare Case of Neoadjuvant Chemotherapy Failure

Cureus ◽

10.7759/cureus.19929 ◽

2021 ◽

Author(s):

Soufiane Boussouni ◽

Gaoussou Touré

Keyword(s):

Neoadjuvant Chemotherapy ◽

Rare Case ◽

Chondroblastic Osteosarcoma

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Giant multinodular infantile fibrosarcoma: a case report

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20180324 ◽

2018 ◽

Vol 6 (2) ◽

pp. 701

Author(s):

Aliyi M. Usman ◽

Okuofo C. Ehiosa ◽

Okwonna O. Charles ◽

Abdullahi Adamu

Keyword(s):

Case Report ◽

Adjuvant Chemotherapy ◽

Soft Tissue ◽

Neoadjuvant Chemotherapy ◽

Rare Case ◽

Surgical Excision ◽

Good Prognosis ◽

Rare Type ◽

Infantile Fibrosarcoma

Infantile fibrosarcoma is a rare type of soft tissue sarcoma seen in children usually less than 2years of age. Few cases of giant infantile fibrosarcoma have been reported in literature. We report a rare case of a giant multi-nodular infantile fibrosarcoma in the left anterolateral chest wall in a 7-year-old boy. The tumour was said to have been recurrent twice for about 6 years. At presentation patient was evaluated and was commenced on 6 cycles of neoadjuvant chemotherapy with vincristine, adriamycin and cyclophosphamide (VAC) regimen to alternate with Ifosfamide/Etoposide (IE) regimen with very good response. Thereafter, had a wide local excision of the tumour and then had 4 more cycles of adjuvant chemotherapy. His 6months follow up showed no evidence of tumour recurrence. Infantile fibrosarcoma is said to be chemo-sensitive tumour with very good response, though surgical excision is the main treatment of choice and overall it is said to have a good prognosis.

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A rare case of locally advanced fibrosarcoma of diaphysal humerus managed successfully with limb-sparing procedures after neoadjuvant chemotherapy

World Journal of Surgical Oncology ◽

10.1186/1477-7819-8-77 ◽

2010 ◽

Vol 8 (1) ◽

Cited By ~ 1

Author(s):

Omar El Mesbahi ◽

Samia Arifi ◽

Zineb Benbrahim ◽

Abdelhalim El Ibrahimi ◽

Fouad Kettani ◽

...

Keyword(s):

Neoadjuvant Chemotherapy ◽

Rare Case ◽

Locally Advanced

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Rhabdomyosarcoma with Pseudolipoblasts Arising in Ovarian Carcinosarcoma: A Distinctive Postchemotherapy Morphologic Variant Mimicking Pleomorphic Liposarcoma

Case Reports in Pathology ◽

10.1155/2014/238545 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Khin Thway ◽

Steve Hazell ◽

Susana Banerjee ◽

Cyril Fisher

Keyword(s):

Neoadjuvant Chemotherapy ◽

Clear Cell ◽

Pleomorphic Liposarcoma ◽

Diagnostic Confusion ◽

Ovarian Carcinosarcoma ◽

Cell Variant ◽

Clear Cell Variant ◽

Unusual Finding

We describe a case of ovarian carcinosarcoma occurring in a 60-year-old female. The neoplasm was excised after neoadjuvant chemotherapy and contained a predominant heterologous pleomorphic rhabdomyosarcomatous component in which there were numerous multivacuolated rhabdomyoblasts that strongly mimicked lipoblasts. The clear cell variant of rhabdomyosarcoma is rarely documented, but this case shows a highly unusual finding in which the rhabdomyoblasts show the prominent multivacuolation with nuclear indentation characteristic of and indistinguishable from pleomorphic lipoblasts. This appears to represent a posttreatment phenomenon. As this finding might conceivably occur in other rhabdomyosarcomas after chemotherapy, we highlight the potential for diagnostic confusion with pleomorphic liposarcoma, which is usually diagnosed by morphology so that immunohistochemistry for muscle markers might not be performed.

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Identification of Pulmonary Deposits from a Sandpaper Worker: A Study by Electron Microscopy and X-Ray Microanalysis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053061 ◽

1982 ◽

Vol 40 ◽

pp. 52-53

Author(s):

S. K. Peng ◽

M.A. Egy ◽

J. K. Singh ◽

M.B. Bishop

Keyword(s):

Electron Microscopy ◽

Environmental Pollution ◽

Rare Case ◽

Interstitial Fibrosis ◽

X Ray ◽

Documented Case ◽

Etiologic Agents ◽

Pulmonary Interstitial Fibrosis ◽

Gold Miners ◽

Pulmonary Changes

Electron microscopy and energy dispersive x-ray microanalysis (EDXA) are found to be very useful tools for identification of etiologic agents in pneumoconiosis or interstitial pulmonary disorders. Pulmonary interstitial fibrosis and granulomatosis are frequently associated with occupational and environmental pollution. Numerous reports of pneumoconiosis in various occupations such as coal and gold miners are presented in the literature. However, there is no known documented case of pulmonary changes in workers in the sandpaper industry. This study reports a rare case of pulmonary granulomatosis containing deposits from abrasives of sandpaper diagnosed by using EDXA.

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