The relationship between disease-related characteristics and conduction disturbances in ankylosing spondylitis

2010 ◽  
Vol 39 (1) ◽  
pp. 38-41 ◽  
Author(s):  
VK Dik ◽  
MJL Peters ◽  
PA Dijkmans ◽  
MAC Van der Weijden ◽  
MK De Vries ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Conduction Disturbances ◽  
The Relationship

The relationship between disease-related characteristics and conduction disturbances in ankylosing spondylitis

2009 ◽  
pp. 1-4
Author(s):  
VK Dik ◽  
MJL Peters ◽  
PA Dijkmans ◽  
MAC Van der Weijden ◽  
MK De Vries ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Conduction Disturbances ◽  
The Relationship

scholarly journals Cardiopulmonary Manifestations of Ankylosing Spondylitis

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Mahnaz Momeni ◽  
Nora Taylor ◽  
Mahsa Tehrani
Keyword(s):  
Ankylosing Spondylitis ◽  
Cardiac Dysfunction ◽  
Spontaneous Pneumothorax ◽  
Pulmonary Complications ◽  
Inflammatory Condition ◽  
Stepwise Approach ◽  
Conduction Disturbances ◽  
Chronic Inflammatory Condition ◽  
Pulmonary Manifestations ◽  
Valve Diseases

Ankylosing spondylitis is a chronic inflammatory condition that usually affects young men. Cardiac dysfunction and pulmonary disease are well-known and commonly reported extra-articular manifestation, associated with ankylosing spondylitis (AS). AS has also been reported to be specifically associated with aortitis, aortic valve diseases, conduction disturbances, cardiomyopathy and ischemic heart disease. The pulmonary manifestations of the disease include fibrosis of the upper lobes, interstitial lung disease, ventilatory impairment due to chest wall restriction, sleep apnea, and spontaneous pneumothorax. They are many reports detailing pathophysiology, hypothesized mechanisms leading to these derangements, and estimated prevalence of such findings in the AS populations. At this time, there are no clear guidelines regarding a stepwise approach to screen these patients for cardiovascular and pulmonary complications.

Complications of axial spondyloarthritis

2016 ◽  
Author(s):  
Stefan Siebert ◽  
Sengupta Raj ◽  
Alexander Tsoukas
Keyword(s):  
Ankylosing Spondylitis ◽  
Cardiovascular Events ◽  
Axial Spondyloarthritis ◽  
Spinal Fractures ◽  
Neurological Complications ◽  
Cardiac Complications ◽  
Minor Trauma ◽  
Conduction Disturbances ◽  
Increased Risk ◽  
Mechanical Constraint

In addition to the well-recognized extra-articular manifestations (EAMs) of ankylosing spondylitis (AS), this condition can also be associated with a number of clinically important complications. While EAMs are considered part of the spondyloarthritis (SpA), the complications are generally a consequence of having the disease. Patients with AS are at increased risk of osteoporosis and spinal fractures. The latter may occur after seemingly minor trauma and may lead to significant neurological compromise. Other potential neurological complications include atlantoaxial subluxation and compressive radiculopathy or myelopathy. Cardiac complications include cardiovascular events, valvular disease, and conduction disturbances. Pulmonary disease in AS relates to parenchymal involvement or mechanical constraint from chest wall inflammation. Renal disease is generally rare in AS.

Zygapophyseal Joint Fusion in Ankylosing Spondylitis Assessed by Computed Tomography: Associations with Syndesmophytes and Spinal Motion

2017 ◽  
Vol 44 (7) ◽  
pp. 1004-1010 ◽  
Author(s):  
Sovira Tan ◽  
Jianhua Yao ◽  
John A. Flynn ◽  
Lawrence Yao ◽  
Michael M. Ward
Keyword(s):  
Computed Tomography ◽  
Ankylosing Spondylitis ◽  
Spinal Mobility ◽  
Vertebral Level ◽  
Spinal Motion ◽  
Zygapophyseal Joints ◽  
Spinal Damage ◽  
Relationship Of ◽  
The Relationship ◽  
Level Fusion

Objective.Because zygapophyseal joints (ZJ) are difficult to visualize on radiographs, little is known about the relationship of ZJ fusion to other features of spinal damage in ankylosing spondylitis (AS). We used computed tomography (CT) to investigate the concordance of ZJ fusion and syndesmophytes, and examined the contribution of both features to spinal motion.Methods.We performed thoracolumbar CT scans (T10–T11 to L3–L4) on 55 patients. Two readers scored scans for ZJ fusion, which were compared to syndesmophyte height and extent of bridging, measured by computer algorithm at the same levels. We used multiple regression analysis to evaluate the relative contributions of ZJ fusion and syndesmophytes to spinal mobility.Results.Fifty-one percent of patients had ZJ fusion in at least 1 vertebral level. Fusion was present in 129 of 652 individual ZJ. Syndesmophytes and bridging were often present in vertebral levels without ZJ fusion, suggesting that syndesmophytes most often develop first. ZJ fusion was present in 34% of vertebral levels with syndesmophytes and 55.9% of levels with bridging, suggesting a closer association with bridging. Syndesmophytes and ZJ fusion had similar associations with the modified Schober test, but syndesmophytes were more strongly associated with limitations in lateral thoracolumbar flexion. ZJ rarely showed new fusion over 4 years.Conclusion.Thoracolumbar ZJ fusion in AS is rarely present at vertebral levels without syndesmophytes. Syndesmophytes, therefore, likely appear before ZJ fusion at a given vertebral level. Both syndesmophytes and ZJ fusion contribute to limited forward lumbar flexion, but syndesmophytes contribute more to limited lateral flexion.

scholarly journals MRI inflammation at the vertebral unit only marginally predicts new syndesmophyte formation: a multilevel analysis in patients with ankylosing spondylitis

2011 ◽  
Vol 71 (3) ◽  
pp. 369-373 ◽  
Author(s):  
Désirée van der Heijde ◽  
Pedro Machado ◽  
Jürgen Braun ◽  
Kay-Geert A Hermann ◽  
Xenofon Baraliakos ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Multilevel Analysis ◽  
Random Sample ◽  
Large Majority ◽  
X Rays ◽  
Multilevel Approach ◽  
Unit Level ◽  
Patient Level ◽  
Spinal Mri ◽  
The Relationship

ObjectiveTo investigate the relationship between MRI inflammation at the vertebral unit and the formation and growth of syndesmophytes at the same vertebral unit.MethodsAn 80% random sample of the ASSERT database was analysed. MRI were scored using the ankylosing spondylitis (AS) spinal MRI activity score (at baseline, 24 and 102 weeks) and spinal x-rays were scored using the modified Stoke AS spine score (at baseline and 102 weeks). Data were analysed at the patient level and the vertebral unit level using a multilevel approach to adjust for within-patient correlation.ResultsThere was a slightly increased probability of developing syndesmophytes in vertebral units with MRI activity, which was maintained after adjustment for within-patient correlation (per vertebral unit level) and treatment, and after further adjustment for potential confounders, resulting in significant OR ranging from 1.51 to 2.26. Growth of existing syndesmophytes at the vertebral unit level was not associated with MRI activity. At the patient level only a trend for an association was observed.ConclusionMRI inflammation in a vertebral unit slightly increases the propensity to form a new syndesmophyte in the same vertebral unit, but does not predict the growth of already existing syndesmophytes. Despite this association, the large majority of new syndesmophytes developed in vertebral units without inflammation. The subtle association at the vertebral unit level did not translate into an association at the patient level.

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