Cardiac Conduction Disturbances, an Underestimated Manifestation in Ankylosing Spondylitis

2009 ◽  
Vol 212 (4) ◽  
pp. 217-224 ◽  
Author(s):  
L. Bergfeldt ◽  
O. Edhag ◽  
H. Vallin
Keyword(s):  
Ankylosing Spondylitis ◽  
Cardiac Conduction ◽  
Conduction Disturbances

scholarly journals Cardiac conduction disturbances in patients with ankylosing spondylitis: results from a 5-year follow-up cohort study

RMD Open ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. e001053 ◽  
Author(s):  
Karin Bengtsson ◽  
Eva Klingberg ◽  
Anna Deminger ◽  
Hanna Wallberg ◽  
Lennart T H Jacobsson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Ankylosing Spondylitis ◽  
Anterior Uveitis ◽  
Beta Blockers ◽  
Cardiac Conduction ◽  
Symptom Duration ◽  
Conduction Disturbances ◽  
History Of ◽  
Age And Sex

ObjectivesTo describe electrocardiographic (ECG) development in patients with ankylosing spondylitis (AS) and identify associations between baseline characteristics and cardiac conduction disturbances (CCD) at 5-year follow-up.MethodsIn a longitudinal cohort study, 172 patients (54% men, mean age (SD) of 50 (13) years at baseline) with AS underwent ECG, physical examination, questionnaires and laboratory testing at baseline and at 5-year follow-up. Descriptive statistics and univariate and age- and sex-adjusted logistic regression analyses were used. CCD included both atrioventricular and intraventricular blocks.ResultsTwenty-three of the 172 patients (13.4%) had a CCD at follow-up. Eight patients had developed a new CCD and eight had normalised their ECG. In the age- and sex-adjusted analyses, CCD at baseline (OR 24.8, 95% CI 7.3 to 84.5), male sex (OR 6.4, 95% CI 2.0 to 20.8), history of anterior uveitis (OR 4.4, 95% CI 1.3 to 14.5), higher ASDAS-CRP (OR 2.3, 95% CI 1.3 to 4.0), greater waist circumference (OR 1.3, 95% CI 1.1 to 1.6, per 5 cm), and medication with antiplatelets (OR 7.0, 95% CI 1.5 to 31.8) and beta-blockers (OR 3.4, 95% CI 1.0 to 11.5) were associated with a CCD at follow-up. Higher age and longer symptom duration were highly correlated and were both associated with a CCD at follow-up.ConclusionsThe presence of CCD in AS is in part dynamic and associated with both AS and non-AS characteristics. Our results suggest that patients especially prone to present with CCDs are older men with a previous CCD, longer symptom duration, higher AS disease activity, a history of anterior uveitis and medication reflecting cardiovascular disease.

scholarly journals Regulation of Cardiac Conduction and Arrhythmias by Ankyrin/Spectrin-Based Macromolecular Complexes

2021 ◽  
Vol 8 (5) ◽  
pp. 48
Author(s):  
Drew Nassal ◽  
Jane Yu ◽  
Dennison Min ◽  
Cemantha Lane ◽  
Rebecca Shaheen ◽  
...  
Keyword(s):  
Ion Channels ◽  
Cardiac Disease ◽  
Conduction System ◽  
Cytoskeletal Proteins ◽  
Cardiac Conduction ◽  
Proper Function ◽  
Cardiac Conduction System ◽  
Loss Of Function ◽  
Macromolecular Complexes ◽  
Conduction Disturbances

The cardiac conduction system is an extended network of excitable tissue tasked with generation and propagation of electrical impulses to signal coordinated contraction of the heart. The fidelity of this system depends on the proper spatio-temporal regulation of ion channels in myocytes throughout the conduction system. Importantly, inherited or acquired defects in a wide class of ion channels has been linked to dysfunction at various stages of the conduction system resulting in life-threatening cardiac arrhythmia. There is growing appreciation of the role that adapter and cytoskeletal proteins play in organizing ion channel macromolecular complexes critical for proper function of the cardiac conduction system. In particular, members of the ankyrin and spectrin families have emerged as important nodes for normal expression and regulation of ion channels in myocytes throughout the conduction system. Human variants impacting ankyrin/spectrin function give rise to a broad constellation of cardiac arrhythmias. Furthermore, chronic neurohumoral and biomechanical stress promotes ankyrin/spectrin loss of function that likely contributes to conduction disturbances in the setting of acquired cardiac disease. Collectively, this review seeks to bring attention to the significance of these cytoskeletal players and emphasize the potential therapeutic role they represent in a myriad of cardiac disease states.

scholarly journals Cardiopulmonary Manifestations of Ankylosing Spondylitis

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Mahnaz Momeni ◽  
Nora Taylor ◽  
Mahsa Tehrani
Keyword(s):  
Ankylosing Spondylitis ◽  
Cardiac Dysfunction ◽  
Spontaneous Pneumothorax ◽  
Pulmonary Complications ◽  
Inflammatory Condition ◽  
Stepwise Approach ◽  
Conduction Disturbances ◽  
Chronic Inflammatory Condition ◽  
Pulmonary Manifestations ◽  
Valve Diseases

Ankylosing spondylitis is a chronic inflammatory condition that usually affects young men. Cardiac dysfunction and pulmonary disease are well-known and commonly reported extra-articular manifestation, associated with ankylosing spondylitis (AS). AS has also been reported to be specifically associated with aortitis, aortic valve diseases, conduction disturbances, cardiomyopathy and ischemic heart disease. The pulmonary manifestations of the disease include fibrosis of the upper lobes, interstitial lung disease, ventilatory impairment due to chest wall restriction, sleep apnea, and spontaneous pneumothorax. They are many reports detailing pathophysiology, hypothesized mechanisms leading to these derangements, and estimated prevalence of such findings in the AS populations. At this time, there are no clear guidelines regarding a stepwise approach to screen these patients for cardiovascular and pulmonary complications.

scholarly journals Cardiac conduction system abnormalities in ankylosing spondylitis: a cross-sectional study

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Helena Forsblad-d’Elia ◽  
Hanna Wallberg ◽  
Eva Klingberg ◽  
Hans Carlsten ◽  
Lennart Bergfeldt
Keyword(s):  
Ankylosing Spondylitis ◽  
Cross Sectional Study ◽  
Conduction System ◽  
Cardiac Conduction ◽  
Cardiac Conduction System ◽  
Sectional Study ◽  
Cross Sectional

Complications of axial spondyloarthritis

2016 ◽  
Author(s):  
Stefan Siebert ◽  
Sengupta Raj ◽  
Alexander Tsoukas
Keyword(s):  
Ankylosing Spondylitis ◽  
Cardiovascular Events ◽  
Axial Spondyloarthritis ◽  
Spinal Fractures ◽  
Neurological Complications ◽  
Cardiac Complications ◽  
Minor Trauma ◽  
Conduction Disturbances ◽  
Increased Risk ◽  
Mechanical Constraint

In addition to the well-recognized extra-articular manifestations (EAMs) of ankylosing spondylitis (AS), this condition can also be associated with a number of clinically important complications. While EAMs are considered part of the spondyloarthritis (SpA), the complications are generally a consequence of having the disease. Patients with AS are at increased risk of osteoporosis and spinal fractures. The latter may occur after seemingly minor trauma and may lead to significant neurological compromise. Other potential neurological complications include atlantoaxial subluxation and compressive radiculopathy or myelopathy. Cardiac complications include cardiovascular events, valvular disease, and conduction disturbances. Pulmonary disease in AS relates to parenchymal involvement or mechanical constraint from chest wall inflammation. Renal disease is generally rare in AS.

The relationship between disease-related characteristics and conduction disturbances in ankylosing spondylitis

2010 ◽  
Vol 39 (1) ◽  
pp. 38-41 ◽  
Author(s):  
VK Dik ◽  
MJL Peters ◽  
PA Dijkmans ◽  
MAC Van der Weijden ◽  
MK De Vries ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Conduction Disturbances ◽  
The Relationship
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