Cardiopulmonary Manifestations of Ankylosing Spondylitis

Ankylosing spondylitis is a chronic inflammatory condition that usually affects young men. Cardiac dysfunction and pulmonary disease are well-known and commonly reported extra-articular manifestation, associated with ankylosing spondylitis (AS). AS has also been reported to be specifically associated with aortitis, aortic valve diseases, conduction disturbances, cardiomyopathy and ischemic heart disease. The pulmonary manifestations of the disease include fibrosis of the upper lobes, interstitial lung disease, ventilatory impairment due to chest wall restriction, sleep apnea, and spontaneous pneumothorax. They are many reports detailing pathophysiology, hypothesized mechanisms leading to these derangements, and estimated prevalence of such findings in the AS populations. At this time, there are no clear guidelines regarding a stepwise approach to screen these patients for cardiovascular and pulmonary complications.

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Pilonidal Cyst of the Penis Mimicking Carcinoma

Case Reports in Urology ◽

10.1155/2013/984757 ◽

2013 ◽

Vol 2013 ◽

pp. 1-2

Author(s):

Luigi Cormio ◽

Francesca Sanguedolce ◽

Paolo Massenio ◽

Giuseppe Di Fino ◽

Giuseppe Carrieri

Keyword(s):

Differential Diagnosis ◽

Pilonidal Sinus ◽

Rare Case ◽

Subcutaneous Tissue ◽

Sinus Tract ◽

Penile Carcinoma ◽

Inflammatory Condition ◽

Pilonidal Cyst ◽

Chronic Inflammatory Condition

Pilonidal sinus is a long-standing chronic inflammatory condition consisting of a sinus tract from the skin-lined orifice extending into subcutaneous tissue, with hairs attached to the wall of the tract and projecting outside of the opening. Penile location is rare, and differential diagnosis with severe balanoposthitis, epidermal cysts, and neoplasms can be difficult. We report a rare case of pilonidal cyst located between coronal sulcus and prepuce which, due to its ulcerated aspect and absence of a tract with projecting hairs, simulated a penile carcinoma.

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TNF-Alpha Inhibitors and Ustekinumab for the Treatment of Psoriasis: Therapeutic Utility in the Era of IL-17 and IL-23 Inhibitors

Journal of Psoriasis and Psoriatic Arthritis ◽

10.1177/24755303211047479 ◽

2022 ◽

pp. 247553032110474

Author(s):

Julie J. Hong ◽

Edward K. Hadeler ◽

Megan L. Mosca ◽

Nicholas D. Brownstone ◽

Tina Bhutani ◽

...

Keyword(s):

Treatment Resistance ◽

Risk Patient ◽

Tnf Alpha ◽

Inflammatory Condition ◽

Biologic Therapies ◽

Malignancy Risk ◽

Patient Demographics ◽

The Past ◽

Chronic Inflammatory Condition ◽

Patient Subgroups

Psoriasis is a chronic inflammatory condition for which eleven FDA-approved biologic therapies are approved. Over the past decade, studies have documented the higher efficacy of IL-17 and IL-23 inhibitors for the treatment of psoriasis compared to the TNF-alpha inhibitors and ustekinumab, an IL-12/23 inhibitor. Despite this, there remains an important role for the use of TNF-alpha inhibitors and ustekinumab in the treatment of psoriasis. Here, we review how considerations of infection and malignancy risk, patient demographics, treatment resistance, and comorbidities may make certain TNF-alpha inhibitors or ustekinumab an excellent choice for therapy in particular patient subgroups.

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Sickle cell disease: a chronic inflammatory condition

Medical Hypotheses ◽

10.1054/mehy.2000.1310 ◽

2001 ◽

Vol 57 (1) ◽

pp. 46-50 ◽

Cited By ~ 38

Author(s):

J.A.B. Chies ◽

N.B. Nardi

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Inflammatory Condition ◽

Cell Disease ◽

Chronic Inflammatory Condition

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Not all colonic growths are malignant

BMJ Case Reports ◽

10.1136/bcr-2019-229515 ◽

2019 ◽

Vol 12 (7) ◽

pp. e229515

Author(s):

Geethu Rachel Iype ◽

Sasank Kalipatnapu ◽

Dipti Masih ◽

Gigi Varghese

Keyword(s):

Inflammatory Condition ◽

Chronic Inflammatory Condition ◽

Xanthogranulomatous Inflammation

We present the case of a 34-year-old woman who was diagnosed to have adenocarcinoma of the caecum based on the clinical, radiological, histopathological and intraoperative findings. However, postoperative histopathology showed only features of xanthogranulomatous inflammation without any evidence of malignancy. This benign chronic inflammatory condition could present as a histological surprise. It is important for both surgeons and pathologists alike to be aware of this.

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Profiling of histone 3 lysine 27 acetylation reveals its role in a chronic DSS-induced colitis mouse model

Molecular Omics ◽

10.1039/c9mo00070d ◽

2019 ◽

Vol 15 (4) ◽

pp. 296-307

Author(s):

Meng Chen ◽

Qinglan Li ◽

Nan Cao ◽

Yanan Deng ◽

Lianyun Li ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Gastrointestinal Tract ◽

Mouse Model ◽

Bowel Disease ◽

Inflammatory Condition ◽

Histone 3 ◽

Chronic Inflammatory Condition ◽

Inflammatory Bowel

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract.

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Periodontal Disease Is an Independent Predictor of Intracardiac Calcification

BioMed Research International ◽

10.1155/2013/854340 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 7

Author(s):

Gregg S. Pressman ◽

Atif Qasim ◽

Nitin Verma ◽

Masami Miyamae ◽

Kumiko Arishiro ◽

...

Keyword(s):

Risk Factors ◽

Periodontal Disease ◽

Subclinical Atherosclerosis ◽

Scoring Systems ◽

Cross Sectional Study ◽

Inflammatory Condition ◽

Cross Sectional ◽

Calcification Score ◽

Chronic Inflammatory Condition ◽

Traditional Risk Factors

Background. Periodontitis is the most common chronic inflammatory condition worldwide and is associated with incident coronary disease.Hypothesis. We hypothesized that periodontal disease would also be associated with cardiac calcification, a condition which shares many risk factors with atherosclerosis and is considered a marker of subclinical atherosclerosis.Methods. Cross-sectional study at two sites (USA and Japan) involving subjects with both clinical echocardiograms and detailed dental examinations. Semiquantitative scoring systems were used to assess severity of periodontal disease and echocardiographic calcification.Results. Fifty-six of 73 subjects (77%) had cardiac calcifications, and 51% had moderate to severe periodontal disease (score > 2). In unadjusted analysis, a significant relationship between periodontal score and cardiac calcification (Spearman rho = 0.4,P=0.001) was noted, with increases in mean calcification score seen across increasing levels of periodontal disease. On multivariate logistic regression, adjusted for age, gender, race, glomerular filtration rate, and traditional risk factors, this association remained significant (P=0.024). There was no significant interaction by study site, race, or gender.Conclusions. In a multiracial population, we found a significant association between the degree of periodontal disease, a chronic inflammatory condition, and cardiac calcification. Further, higher periodontal scores were associated with greater degrees of calcification.

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Complications of axial spondyloarthritis

10.1093/med/9780198755296.003.0009 ◽

2016 ◽

Author(s):

Stefan Siebert ◽

Sengupta Raj ◽

Alexander Tsoukas

Keyword(s):

Ankylosing Spondylitis ◽

Cardiovascular Events ◽

Axial Spondyloarthritis ◽

Spinal Fractures ◽

Neurological Complications ◽

Cardiac Complications ◽

Minor Trauma ◽

Conduction Disturbances ◽

Increased Risk ◽

Mechanical Constraint

In addition to the well-recognized extra-articular manifestations (EAMs) of ankylosing spondylitis (AS), this condition can also be associated with a number of clinically important complications. While EAMs are considered part of the spondyloarthritis (SpA), the complications are generally a consequence of having the disease. Patients with AS are at increased risk of osteoporosis and spinal fractures. The latter may occur after seemingly minor trauma and may lead to significant neurological compromise. Other potential neurological complications include atlantoaxial subluxation and compressive radiculopathy or myelopathy. Cardiac complications include cardiovascular events, valvular disease, and conduction disturbances. Pulmonary disease in AS relates to parenchymal involvement or mechanical constraint from chest wall inflammation. Renal disease is generally rare in AS.

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