Faecal Blood Loss During Administration of Acetylsalicylic Acid, Ketoprofen and Two New Ketoprofen Sustained-Release Compounds

1983 ◽  
Vol 12 (3) ◽  
pp. 280-284 ◽  
Author(s):  
Poul Jergen Ranløv ◽  
Stig Pors Nielsen ◽  
Olaf Bärenholdt
Keyword(s):  
Blood Loss ◽  
Sustained Release ◽  
Acetylsalicylic Acid ◽  
Faecal Blood Loss

Gastro-Intestinal Blood Loss during Administration of Indoprofen, Aspirin and Ibuprofen

1977 ◽  
Vol 5 (3) ◽  
pp. 155-160 ◽  
Author(s):  
G Bianchi Porro ◽  
G Corvi ◽  
L M Fuccella ◽  
G C Goldaniga ◽  
G Valzelli
Keyword(s):  
Blood Loss ◽  
Acetylsalicylic Acid ◽  
Fold Increase ◽  
Acute Effect ◽  
Gastrointestinal Mucosa ◽  
Order Of Magnitude ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Faecal Blood Loss

The acute effect of three non-steroidal anti-inflammatory drugs, ibuprofen, acetylsalicylic acid (ASA) and indoprofen, on faecal blood loss was investigated in 15 subjects by means of 51Cr-labelled erythrocytes. Ibuprofen (900 mg/day for 5 days) and indoprofen capsules and tablets (300 mg and 600 mg/day for 5 days, respectively) slightly increased the amount of blood eliminated in faeces. The increase was of the same order of magnitude for both doses of indoprofen. ASA (1,500 mg/day for 5 days) caused about a 6-fold increase in blood loss. Four days after withdrawal of ASA, faecal blood was still about twice as high as in faeces of subjects given ibuprofen and indoprofen. The method appears sensitive and reliable for comparison of the immediate effect of anti-inflammatory drugs on gastrointestinal mucosa.

Studies on Ponstan (Mefenamic Acid): I. Gastro-Intestinal Blood Loss; II. Absorbtion and Excretion of a New Formulation

1975 ◽  
Vol 3 (3) ◽  
pp. 176-182 ◽  
Author(s):  
A R Tali ◽  
S P Mistilis
Keyword(s):  
Blood Loss ◽  
Mefenamic Acid ◽  
Control Level ◽  
Serum Levels ◽  
Intestinal Bleeding ◽  
Level Curves ◽  
Significant Difference ◽  
Coated Tablet ◽  
New Formulation ◽  
Faecal Blood Loss

Using improved techniques in a study of faecal blood loss no significant change over control level occurred during administration of mefenamic acid 500 mg t.i.d. for six days. This lack of gastro-intestinal bleeding is at variance with earlier findings for this compound. Studies of two mefenamic acid formulations (250 mg capsule and 500 mg filmseal tablet) showed no significant difference in area under blood level curves or in urinary output data, indicating equivalent total absorption. The 500 mg film-coated tablet gave significantly higher serum levels at 0·5 hours, whereas the 250 mg capsule gave significantly higher serum levels at 6 and 8 hours.

scholarly journals Influence of Salicylate Administration on Iron Metabolism

Blood ◽  
1962 ◽  
Vol 19 (5) ◽  
pp. 601-611 ◽  
Author(s):  
G. IZAK ◽  
K. GALEWSKY-STEIN ◽  
J. MENCZEL ◽  
J. J. GROEN
Keyword(s):  
Blood Loss ◽  
Gastrointestinal Bleeding ◽  
Acetylsalicylic Acid ◽  
Survival Time ◽  
Iron Metabolism ◽  
Serum Iron ◽  
Normal Subjects ◽  
Red Cells ◽  
Unknown Mechanism ◽  
Chemical Interference

Abstract In nine patients with various diseases and in two normal subjects, administration of acetylsalicylic acid (aspirin) in amounts of 3-4 Gm. per day produced a drop in serum iron. This drop could not be explained by chemical interference with the determination, by blood loss, impaired absorption or increased excretion of iron. In addition, it was shown that during administration of salicylates the survival time of the red cells was diminished. It is suggested that salicylates might produce anemia not only by gastrointestinal bleeding but also by interference with the metabolism of iron through some unknown mechanism.

A New Bleeding Model: Effects of Compounds on the Mechanically Induced Blood Loss of Small Subdermal Vessels of the Rat

1979 ◽  
Author(s):  
P.M.J. Hobbelen ◽  
A.W.M. Princen ◽  
A.M.L. van Delft
Keyword(s):  
Blood Loss ◽  
Acetylsalicylic Acid ◽  
Bleeding Time ◽  
Drug Effects ◽  
Clinical Situation ◽  
Male Rats ◽  
Small Vessels ◽  
Number Of Patients ◽  
Higher Doses ◽  
Large Vessels

Several models are described for the measurement of drug effects on bleeding. The-haemostatic mechanism in large vessels is largely dissimilar from that in small vessels. Pharmacological bleeding models in which small vessels are used can be expected to be most relevant for the clinical situation, but these models have the disadvantage of a low reproducibility. Therefore, We developed a model in which reproducible bleeding is induced in small vessels. Male rats are anaesthetized with Nembutal®. The bleeding is induced by ripping off a flap of abdominal slcin from the underlying tissue. The “wound” is covered with a gauze and blood loss·is measured. Low doses of heparin (~350 IU/kg i.v.) which block the formation of fibrin do not affect the blood loss. However, higher doses of heparin (~700 and 1400 IU/kg i.v.) increase the blood loss significantly. Blood loss is also increased by treatment withanti-platelet serum. Acetylsalicylic acid, sulfinpyrazone and Org 4122 in doset active in experimental arterial thrombosis, do not affect the blood loss. There is no agreement in literature about the effects of acetylsalicylic acid and sulfinpyrazone in clinical bleeding time tests, but heparin, when given as i.v. bolus injections (7500-10000 IU) induces bleeding in quite a number of patients. Because our results are comparable to results obtained in humans and because of the good reproducibility, this test has advantages above other existing animal bleeding tests.

Occult Faecal Blood Loss Determined by Chemical Tests and a51Cr Method

1981 ◽  
Vol 16 (2) ◽  
pp. 245-252 ◽  
Author(s):  
J. H. Dybdahl ◽  
L. N. W. Daae ◽  
S. Larsen
Keyword(s):  
Blood Loss ◽  
Faecal Blood Loss

Faecal Blood Loss Associated with Aspirin and Pentoxifylline, Given Alone and in Combination

1992 ◽  
Vol 4 (3) ◽  
pp. 215-218 ◽  
Author(s):  
Bernhardt Meyer ◽  
Frank Muller ◽  
Herman Luus ◽  
Thys Lotter
Keyword(s):  
Blood Loss ◽  
Faecal Blood Loss
Sign in / Sign up

Export Citation Format

Share Document