scholarly journals Association of Conicity Index and Renal Progression in Pre-dialysis Chronic Kidney Disease

Renal Failure ◽  
2012 ◽  
Vol 34 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Siren Sezer ◽  
Şebnem Karakan ◽  
Nurhan Özdemir Acar
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Progression ◽  
Conicity Index

The Relationship Between Blood Pressure Variability And Renal Progression In Hypertensive Patients With Chronic Kidney Disease

2021 ◽  
Vol 6 (14) ◽  
pp. 80-88
Author(s):  
Huseyin Duru ◽  
Ekrem KARA
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Blood Pressure Measurement ◽  
Rapid Progression ◽  
Night Time ◽  
Hypertensive Patients ◽  
Significant Difference ◽  
Renal Progression

Objective: To evaluate the effect of 24 hour systolic blood pressure (SBP) and diastolic blood pressure (DBP) variability (BPV) on renal progression in hypertensive patients with chronic kidney disease (CKD) Methods: A total 59 hypertensive patients (mean age: 54.2±14.6 years, 50.8% male) with CKD who underwent 24 hours ambulatory blood pressure measurement (ABPM) were included. Data on SBP, DBP, BPV coefficients (VC) for SBP (SBP-CV) and DBP (DBP-CV) were recorded. A decrease in e-GFR of <5 ml/min/year was considered as normal renal progression and a decrease in ≥5 ml/min/year was considered as rapid renal progression. Results: Overall, 40.6% of the patients had uncontrolled HT, while 45.8% had non-dipper pattern. Mean±SD daytime and night-time SBP and SBP-VC values were 135.3±17.9 mmHg, 128.6±23.0 mmHg, 11.7±2.8 and 9.5±3.6, respectively. Mean±SD daytime and nigh-time DBP and DBP-VC values were 84.5±13.4 mmHg, 77.2±16.1 mmHg, 13.8±3.8 and 12.0±3.7, respectively. Rapid renal progression was detected in 25.4% of patients with no significant difference in daytime, night-time and total SBP, SBP-VC, DBP and DBP-VC values between patients with rapid vs. natural renal progression. The regression analysis adjusted for age, gender, presence of DM, baseline e-GFR and dipping status revealed no significant impact of SBP-VC and DBP-VC in predicting rapid progression (p> 0.05). Conclusion: In conclusion, our finding revealed no significant association between BPV and renal progression in hypertensive patients with CKD. Larger scale prospective, randomized controlled trials with longer follow-up are needed to clarify this issue.

scholarly journals Predictive factors of rapid linear renal progression and mortality in patients with chronic kidney disease

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Ibrahim Ali ◽  
Rajkumar Chinnadurai ◽  
Sara T. Ibrahim ◽  
Darren Green ◽  
Philip A. Kalra
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Predictive Factors ◽  
Renal Progression

scholarly journals Risk factors of gender for renal progression in patients with early chronic kidney disease

Medicine ◽  
2016 ◽  
Vol 95 (30) ◽  
pp. e4203 ◽  
Author(s):  
Po-Ya Chang ◽  
Li-Nien Chien ◽  
Yuh-Feng Lin ◽  
Mai-Szu Wu ◽  
Wen-Ta Chiu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Progression

scholarly journals FP314A RISK SCORING MODEL TO PREDICT RENAL PROGRESSION IN CHRONIC KIDNEY DISEASE PATIENTS WITH CONTRAST INDUCED NEPHROPATHY

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i137-i137
Author(s):  
Seung Don Baek ◽  
Mun Jang ◽  
Wonhak Kim ◽  
Eun Kyoung Lee ◽  
So Mi Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Contrast Induced Nephropathy ◽  
Scoring Model ◽  
Risk Scoring ◽  
Renal Progression

scholarly journals RR15. Renal Progression in the Advanced Chronic Kidney Disease Populations: Creation of the ESRD Prediction Scorecard

2015 ◽  
Vol 61 (6) ◽  
pp. 195S
Author(s):  
Marcos K. Lau ◽  
Joy L. Meier ◽  
Warren Gasper ◽  
David H. Lovett ◽  
Pauline M. Velez ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Advanced Chronic Kidney Disease ◽  
Renal Progression

scholarly journals A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression

2020 ◽  
Vol 15 ◽  
pp. 117727192097614
Author(s):  
Ibrahim Ali ◽  
Sara T Ibrahim ◽  
Rajkumar Chinnadurai ◽  
Darren Green ◽  
Maarten Taal ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Biomarker Discovery ◽  
Personalised Medicine ◽  
Adverse Outcomes ◽  
Chronic Kidney Disease Progression ◽  
Ckd Progression ◽  
New Era ◽  
Kidney Disease Progression ◽  
Renal Progression

Biomarker discovery in the field of risk prediction in chronic kidney disease (CKD) embraces the prospect of improving our ability to risk stratify future adverse outcomes and thereby guide patient care in a new era of personalised medicine. However, many studies that report biomarkers predictive of CKD progression share a key methodological limitation: failure to characterise patients’ renal progression precisely. This weakens any observable association between a biomarker and an outcome poorly defined by a patient’s change in renal function over time. In this commentary, we discuss the need for a better approach in this research arena and describe a compelling strategy that has the advantage of offering robust and meaningful biomarker exploration relevant to CKD progression.

The effect of interactions between proteinuria, activity of fibroblast growth factor 23 and serum phosphate on renal progression in patients with chronic kidney disease: a result from the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease study

2019 ◽  
Vol 35 (3) ◽  
pp. 438-446 ◽  
Author(s):  
Hyoungnae Kim ◽  
Jimin Park ◽  
Ki Heon Nam ◽  
Jong Hyun Jhee ◽  
Hae-Ryong Yun ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Significant Interaction ◽  
Independent Risk Factor ◽  
Fibroblast Growth Factor 23 ◽  
Serum Phosphate ◽  
Ckd Progression ◽  
Biologic Activity ◽  
Renal Progression ◽  
Fgf 23

Abstract Background Recent experimental study reported that proteinuria increases serum phosphate by decreasing biologic activity of fibroblast growth factor 23 (FGF-23). We examined this relationship in a large chronic kidney disease (CKD) cohort and evaluated the combined effect of proteinuria, FGF-23 activity and serum phosphate on CKD progression. Methods The activity of FGF-23, measured by the fractional excretion of phosphate (FEP)/FGF-23 ratio, was compared according to the degree of proteinuria in 1909 patients with CKD. Primary outcome was CKD progression defined as ≥50% decline of estimated glomerular filtration rate, doubling of serum creatinine and start of dialysis. Results There was a negative relationship between 24-h urine protein (24-h UP) and FEP/FGF-23 ratio (γ −0.07; P = 0.005). In addition, after matching variables associated with serum phosphate, patients with more proteinuria had higher serum phosphate (P &lt; 0.001) and FGF-23 (P = 0.012), and lower FEP/FGF-23 ratio (P = 0.007) compared with those with less proteinuria. In the matched cohort, low FEP/FGF-23 ratio was an independent risk factor for CKD progression (hazard ratio 0.87 per 1 log increase; 95% confidence interval 0.79–0.95; P = 0.002), and there was significant interaction between 24-h UP and FEP/FGF-23 ratio (P = 0.039). Furthermore, 24-h UP and serum phosphate also had a significant interaction on CKD progression (P &lt; 0.001). Conclusions Proteinuria is associated with decreased biologic activity of FGF-23 and increased serum phosphate. Furthermore, diminished activity of FGF23 is an independent risk factor for renal progression in proteinuric CKD patients.

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