Chronic stress and carbohydrate metabolism: Persistent changes and slow return to normalcy in male albino rats

Stress ◽  
2011 ◽  
Vol 15 (3) ◽  
pp. 262-271 ◽  
Author(s):  
R. Nirupama ◽  
M. Devaki ◽  
H.N. Yajurvedi
Keyword(s):  
Carbohydrate Metabolism ◽  
Chronic Stress ◽  
Albino Rats

Effect of induced bilateral cryptorchidism on the carbohydrate metabolism of reproductive tissues in albino rats

1983 ◽  
Vol 91 (5) ◽  
pp. 405-410 ◽  
Author(s):  
K. Venkatarami Reddy ◽  
N. Geethanjali ◽  
Y. Dhananjaya Reddy ◽  
P. Reddanna ◽  
S. Govindappa
Keyword(s):  
Carbohydrate Metabolism ◽  
Albino Rats ◽  
Reproductive Tissues ◽  
Bilateral Cryptorchidism

Attenuation of Helicteres isora L. bark extracts on streptozotocin-induced alterations in glycogen and carbohydrate metabolism in albino rats

2009 ◽  
Vol 28 (11) ◽  
pp. 689-696 ◽  
Author(s):  
G. Kumar ◽  
G. Sharmila Banu ◽  
AG Murugesan
Keyword(s):  
Skeletal Muscle ◽  
Carbohydrate Metabolism ◽  
Glycogen Content ◽  
Bark Extract ◽  
Albino Rats ◽  
Glucose Levels ◽  
Helicteres Isora ◽  
Insulin Dependent ◽  
Hypoglycemic Drug ◽  
Normal Controls

The present study was undertaken to assess the effect of Helicteres isora L. on four important enzymes of carbohydrate metabolism (glucokinase [GK], hexokinase [HK] phosphofructokinase [PFK] and fructose-1, 6-bisphosphatase [FBP]) along with glycogen content of insulin-dependent (skeletal muscle and liver) and insulin-independent tissues (kidneys and brain) in streptozotocin (STZ; 60 mg/kg)-induced model of diabetes for 30 days. Administration of bark extracts (100, 200 mg/kg) for 30 days led to decrease in plasma glucose levels by approximately 9.60% and 22.04% and 19.18% and 33.93% on 15th and 30th day, respectively, of the experiment. Liver and two-kidney weight expressed as percentage of body weight significantly increased in diabetics (P < 0.05) versus normal controls. Renal glycogen content increased by 10 folds while hepatic and skeletal muscle glycogen content decreased by 75% and 68% in diabetic controls versus controls. H. isora did not affect glycogen content in any tissue. The decreased activities of PFK, GK, FBP and HK in diabetic controls were 40%, 50%, 50% and 60% and bark extract of H. isora partially corrected this alteration. The efficacy of the bark extract was comparable with Tolbutamide, a well-known hypoglycemic drug.

Contrasting effects of stress and cortisol overdosage in the rat

1959 ◽  
Vol 196 (5) ◽  
pp. 946-948 ◽  
Author(s):  
C. E. Hall ◽  
O. Hall
Keyword(s):  
Blood Pressure ◽  
Chronic Stress ◽  
Body Growth ◽  
Pressure Effects ◽  
Albino Rats ◽  
Thymus Involution ◽  
Electrical Shocks ◽  
Blood Pressure Effects ◽  
Stress States ◽  
Preputial Glands

Immature female albino rats were subjected to chronic stress and to cortisol overdosage singly and in combination. At a dosage of 1 mg/day the steroid produced slight augmentation of blood pressure, moderate inhibition of growth and great involution of the thymus. Stress, in the form of intermittently applied electrical shocks, although it had little effect on the thymus or on body growth, produced slight adrenal hypertrophy and a considerable hypertrophy of the preputial glands. Stress and cortisol together acted synergistically on body growth and thymus involution; but cortisol dominated the adrenal response and stress that of the preputial glands. There was only suggestive evidence that blood pressure effects of cortisol were augmented by stress. The possible usefulness of preputial hypertrophy in the assessment of chronic stress states is discussed.

CHRONIC FORCED SWIMMING INDUCED STRESS ALTERS BEHAVIOURAL, HISTOLOGICAL AND ANTI-OXIDANT STATUS

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (06) ◽  
pp. 58-64
Author(s):  
S. K Prusty ◽  
◽  
A. K Pati ◽  
B. B. Subudhi ◽  
P. K. Sahu
Keyword(s):  
Chronic Stress ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Albino Rats ◽  
Tissue Degeneration ◽  
Swimming Stress ◽  
Group I ◽  
Anti Oxidant ◽  
Swimming Test ◽  
Oxidant Status

exposure to chronic stress is an important factor of neurodegeneration. Forced swimming test is a common model for chronic stress which needs validation in terms of duration of exposure and correlation of behavioural, histological and anti-oxidant status. Adult wistar albino rats (150-200 g) of both sexes were divided into two groups. Group I treated as control and Group II animals were subjected to forced swimming test for 30 minutes daily. On different days (0, 3,7,15 and 30) effect on behavioural, histological and anti-oxidant status was evaluated. Swimming stress of 30 minutes daily for 15 days significantly (p<0.05) decreased the time of fall in rotarod, locomotor activity in actophotometer, number of correct entries in radial maze, superoxide dismutase (SOD) level and significantly (p<0.05) increased the malondialdehyde (MDA) content along with prominent tissue degeneration in brain, heart, liver and kidney. The present study reveals that 30 minutes exposure to forced swimming for 15 days can be a novel model of chronic stress as it results in significant alterations in behavioural, histological and antioxidant status.

scholarly journals Decaffeinated Coffee Consumption and Renal Function Impairment in Health and Diabetes: A Paradigm-Shift

2020 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Renal Function ◽  
Carbohydrate Metabolism ◽  
Coffee Consumption ◽  
Serum Glucose ◽  
Caffeine Intake ◽  
Albino Rats ◽  
Bioactive Constituents ◽  
Male And Female ◽  
Decaffeinated Coffee ◽  
Group 2

Aim: The belief that decaffeinated coffee (DCAF) does not contain a physiologically relevant concentration of caffeine and therefore has no significant adverse effect on renal endpoints makes patients who are vulnerable to renal dysfunction, renal compromised state, medical conditions that contraindicate caffeine intake or those already on prescription medications known to adversely affect the kidney to sometimes substitute DCAF for caffeinated coffee even as the credibility of this paradigm remains disputable. Therefore, the present study aimed to assess the effect of DCAF consumption on markers of renal function and carbohydrate metabolism in health and diabetes. Materials and Methods: Sixty Wistar Albino rats were divided into 12 groups (6pairs) (n=5per group) for male and female animals. Animals in group 1 served as normal control (NCTRL) and were given standard feed and water only. Animals in group 2 received standard feed plus DCAF. Group 3 was the diabetic (DIA) only group while groups 4, 5, and 6 were DIA plus DCAF treatment groups. After 4weeks of treatment, animals were sacrificed and blood obtained and analyzed for the biochemical indices of renal function and carbohydrate metabolism using standard methods. Results: Serum creatinine (SCr) levels increased significantly in all DCAF treated groups compared with the NCTRL group in male and female animals. Serum electrolytes did not show any significant change across groups. Serum Urea (SUr) increased and decreased in DIA alone group and DIA plus DCAF groups respectively. Serum glucose, insulin, and HOMA-IR increased and decreased significantly in DIA alone group and DIA plus DCAF treated groups respectively compared with NCTRL and DCAF control groups. Conclusion: The consumption of DCAF may adversely affect renal endpoints in health and diabetes but improves markers of carbohydrate metabolism in diabetes likely due to the re-enforcement effect of its caffeine and other bioactive constituents.

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